7TFP

Human Ornithine Aminotransferase cocrystallized with its inhibitor, (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.

Summary for 7TFP

Entry DOI	10.2210/pdb7tfp/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid, ... (4 entities in total)
Functional Keywords	human ornithine aminotransferase, hoat, oat, mechanism-based inhibitor, mbi, irreversible inhibitor, inactivator, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	135483.56
Authors	Butrin, A.,Zhu, W.,Silverman, R.,Liu, D. (deposition date: 2022-01-06, release date: 2022-04-06, Last modification date: 2023-10-18)
Primary citation	Zhu, W.,Butrin, A.,Melani, R.D.,Doubleday, P.F.,Ferreira, G.M.,Tavares, M.T.,Habeeb Mohammad, T.S.,Beaupre, B.A.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. J.Am.Chem.Soc., 144:5629-5642, 2022 Cited by PubMed: 35293728 DOI: 10.1021/jacs.2c00924 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation