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PDB: 1666 results

3PWR
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HIV-1 Protease Mutant L76V complexed with Saquinavir
Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, GLYCEROL, ...
Authors:Zhang, Y, Weber, I.T.
Deposit date:2010-12-08
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts.
Biochemistry, 50, 2011
2ALM
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BU of 2alm by Molmil
Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
Descriptor: 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION
Authors:Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O.
Deposit date:2005-08-07
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.
J.Biol.Chem., 281, 2006
4HBG
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Crystal structure of Saccharomyces cerevisiae 3 oxoacyl-[acyl carrier protein]-reductase complexed with NADPH (form2)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, Y.J, Gao, Y.X, Teng, M.K.
Deposit date:2012-09-27
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of yeast mitochondria 3-Oxoacyl-ACP Reductase OAR1
To be Published
4H6P
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BU of 4h6p by Molmil
Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a R101A substitution.
Descriptor: Chromate reductase, FLAVIN MONONUCLEOTIDE
Authors:Zhang, Y, Robinson, H, Buchko, G.W.
Deposit date:2012-09-19
Release date:2012-10-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.556 Å)
Cite:Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii
To be Published
4K7E
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BU of 4k7e by Molmil
Crystal structure of Junin virus nucleoprotein
Descriptor: Nucleoprotein
Authors:Zhang, Y.J, Li, L, Liu, X, Dong, S.S, Wang, W.M, Huo, T, Rao, Z.H, Yang, C.
Deposit date:2013-04-17
Release date:2013-08-07
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Junin virus nucleoprotein
J.Gen.Virol., 94, 2013
5Z1W
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BU of 5z1w by Molmil
Cryo-EM structure of polycystic kidney disease-like channel PKD2L1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystic kidney disease 2-like 1 protein
Authors:Zhang, Y.Q.
Deposit date:2017-12-28
Release date:2018-03-28
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.
Nat Commun, 9, 2018
4HS4
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BU of 4hs4 by Molmil
Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a Y129N substitution.
Descriptor: Chromate reductase, FLAVIN MONONUCLEOTIDE
Authors:Zhang, Y, Robinson, H, Buchko, G.W.
Deposit date:2012-10-29
Release date:2012-12-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii
To be Published
8IHT
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BU of 8iht by Molmil
Rpd3S bound to the nucleosome
Descriptor: CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ...
Authors:Zhang, Y, Gang, C.
Deposit date:2023-02-23
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Cell Res., 33, 2023
8IHM
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BU of 8ihm by Molmil
Eaf3 CHD domain bound to the nucleosome
Descriptor: Chromatin modification-related protein EAF3, DNA (164-MER), DNA (165-MER), ...
Authors:Zhang, Y, Gang, C.
Deposit date:2023-02-23
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Cell Res., 33, 2023
8IHN
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BU of 8ihn by Molmil
Cryo-EM structure of the Rpd3S core complex
Descriptor: CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ...
Authors:Zhang, Y, Gang, C.
Deposit date:2023-02-23
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Cell Res., 33, 2023
2A9Z
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BU of 2a9z by Molmil
Crystal structure of T. gondii adenosine kinase complexed with N6-dimethyladenosine and AMP-PCP
Descriptor: 6N-DIMETHYLADENOSINE, CHLORIDE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Zhang, Y, el Kouni, M.H, Ealick, S.E.
Deposit date:2005-07-12
Release date:2006-07-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase
Acta Crystallogr.,Sect.D, 63, 2007
6XNY
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BU of 6xny by Molmil
Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Paired-Form)
Descriptor: 12RSS integration strand (55-mer), 12RSS signal DNA top strand (34-mer), 23RSS integration strand (66-mer), ...
Authors:Zhang, Y, Corbett, E, Wu, S, Schatz, D.G.
Deposit date:2020-07-05
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Embo J., 39, 2020
6BGN
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BU of 6bgn by Molmil
Crystal Structure of 4-Oxalocrotonate Tautomerase After Incubation with 5-Fluoro-2-hydroxy-2,4-pentadienoate
Descriptor: 2-hydroxymuconate tautomerase, 5-fluoranyl-2-oxidanylidene-pentanoic acid, GLYCEROL, ...
Authors:Zhang, Y, Li, W, Stack, T.
Deposit date:2017-10-29
Release date:2018-02-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.
Biochemistry, 57, 2018
6XNX
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BU of 6xnx by Molmil
Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Dynamic-Form)
Descriptor: 12RSS integration strand DNA (55-MER), 12RSS signal top strand DNA (34-MER), 23RSS integration strand DNA (66-MER), ...
Authors:Zhang, Y, Corbett, E, Wu, S, Schatz, D.G.
Deposit date:2020-07-05
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Embo J., 39, 2020
5LS6
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BU of 5ls6 by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
Descriptor: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
Authors:Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
6M0W
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BU of 6m0w by Molmil
Crystal structure of Streptococcus thermophilus Cas9 in complex with the AGAA PAM
Descriptor: CRISPR-associated endonuclease Cas9 1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*GP*AP*AP*GP*C)-3'), ...
Authors:Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q.
Deposit date:2020-02-23
Release date:2020-09-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Nat Catal, 2020
4OIP
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BU of 4oip by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
6M0X
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BU of 6m0x by Molmil
Crystal structure of Streptococcus thermophilus Cas9 in complex with AGGA PAM
Descriptor: BARIUM ION, CRISPR-associated endonuclease Cas9 1, DNA (28-MER), ...
Authors:Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q.
Deposit date:2020-02-23
Release date:2020-09-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.561 Å)
Cite:Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Nat Catal, 2020
6M0V
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BU of 6m0v by Molmil
Crsytal structure of streptococcus thermophilus Cas9 in complex with the GGAA PAM
Descriptor: BARIUM ION, CRISPR-associated endonuclease Cas9 1, DNA (28-MER), ...
Authors:Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q.
Deposit date:2020-02-22
Release date:2020-09-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Nat Catal, 2020
2ABS
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BU of 2abs by Molmil
Crystal structure of T. gondii adenosine kinase complexed with AMP-PCP
Descriptor: CHLORIDE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SODIUM ION, ...
Authors:Zhang, Y, el Kouni, M.H, Ealick, S.E.
Deposit date:2005-07-16
Release date:2006-01-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.
Acta Crystallogr.,Sect.D, 62, 2006
4OIR
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BU of 4oir by Molmil
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIQ
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BU of 4oiq by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.624 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
2A9Y
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BU of 2a9y by Molmil
Crystal structure of T. gondii adenosine kinase complexed with N6-dimethyladenosine
Descriptor: 6N-DIMETHYLADENOSINE, ACETATE ION, CHLORIDE ION, ...
Authors:Zhang, Y, el Kouni, M.H, Ealick, S.E.
Deposit date:2005-07-12
Release date:2006-07-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase
Acta Crystallogr.,Sect.D, 63, 2007
3LC8
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Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion (Maltose-free form)
Descriptor: GLYCEROL, MAGNESIUM ION, Maltose-binding periplasmic protein, ...
Authors:Zhang, Y, Garavito, R.M.
Deposit date:2010-01-10
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein.
Biochem.Biophys.Res.Commun., 407, 2011
2AA0
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BU of 2aa0 by Molmil
Crystal structure of T. gondii adenosine kinase complexed with 6-methylmercaptopurine riboside
Descriptor: 2-HYDROXYMETHYL-5-(6-METHYLSULFANYL-PURIN-9-YL)-TETRAHYDRO-FURAN-3,4-DIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Zhang, Y, el Kouni, M.H, Ealick, S.E.
Deposit date:2005-07-13
Release date:2006-07-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase
Acta Crystallogr.,Sect.D, 63, 2007

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