8JUA

Multifunctional cytochrome P450 enzyme IkaD from Streptomyces sp. ZJ306, in complex with epoxyikarugamycin

Summary for 8JUA

Entry DOI	10.2210/pdb8jua/pdb
Related	8JNC 8JNO 8JOO
Descriptor	Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (1Z,3E,5S,7R,8R,10R,11R,12S,13R,15S,16R,17S,19Z,26S)-11-ethyl-2-hydroxy-10-methyl-22,27-diaza-14 oxahexacyclo[24.2.1.05,17.07,16.013,15.08,12]nonacosa-1(2),3,19-triene-21,28,29-trione, ... (5 entities in total)
Functional Keywords	c-h functionalization, regioselectivity, chemoselectivity, polycyclic tetramate macrolactam (potem), cytochrome p450 enzyme, oxidoreductase
Biological source	Streptomyces sp. ZJ306
Total number of polymer chains	2
Total formula weight	98707.34
Authors	Zhang, Y.L.,Zhang, L.P.,Zhang, C.S. (deposition date: 2023-06-26, release date: 2023-11-15, Last modification date: 2023-12-20)
Primary citation	Jiang, P.,Jin, H.,Zhang, G.,Zhang, W.,Liu, W.,Zhu, Y.,Zhang, C.,Zhang, L. A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62:e202310728-e202310728, 2023 Cited by PubMed: 37917570 DOI: 10.1002/anie.202310728 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.00001111553 Å)

Structure validation