2BCC
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![BU of 2bcc by Molmil](/molmil-images/mine/2bcc) | STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.I, Kim, K.K, Hung, L.W, Crofts, A.R, Berry, E.A, Kim, S.H. | Deposit date: | 1998-09-18 | Release date: | 1999-08-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Electron Transfer by Domain Movement in Cytochrome Bc1 Nature, 392, 1998
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3HIA
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![BU of 3hia by Molmil](/molmil-images/mine/3hia) | Crystal structure of the choline binding domain of Spr1274 in Streptococcus pneumoniae | Descriptor: | Choline binding protein, PHOSPHOCHOLINE, SULFATE ION | Authors: | Zhang, Z.-Y, Li, W.-Z, Jiang, Y.-L, Bao, R, Zhou, C.-Z, Chen, Y.-X. | Deposit date: | 2009-05-19 | Release date: | 2009-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of the choline binding domain of Spr1274 in Streptococcus pneumoniae To be Published
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6LVX
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![BU of 6lvx by Molmil](/molmil-images/mine/6lvx) | Crystal structure of TLR7/Cpd-1 (SM-374527) complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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8IXI
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![BU of 8ixi by Molmil](/molmil-images/mine/8ixi) | |
5GMF
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![BU of 5gmf by Molmil](/molmil-images/mine/5gmf) | Crystal structure of monkey TLR7 in complex with guanosine and polyU | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2016-07-14 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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8DHX
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![BU of 8dhx by Molmil](/molmil-images/mine/8dhx) | Human liver ferritin | Descriptor: | Ferritin heavy chain | Authors: | Zhang, Z. | Deposit date: | 2022-06-28 | Release date: | 2023-07-12 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Human liver ferritin To Be Published
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8HIJ
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![BU of 8hij by Molmil](/molmil-images/mine/8hij) | The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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8HIK
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![BU of 8hik by Molmil](/molmil-images/mine/8hik) | The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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8HII
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![BU of 8hii by Molmil](/molmil-images/mine/8hii) | The BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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5GMH
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![BU of 5gmh by Molmil](/molmil-images/mine/5gmh) | Crystal structure of monkey TLR7 in complex with R848 | Descriptor: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2016-07-14 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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3G0C
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![BU of 3g0c by Molmil](/molmil-images/mine/3g0c) | Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(2-chlorobenzyl)-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione, ... | Authors: | Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L. | Deposit date: | 2009-01-27 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. J.Med.Chem., 54, 2011
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8F4R
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![BU of 8f4r by Molmil](/molmil-images/mine/8f4r) | Gentamicin bound aminoglycoside efflux pump AcrD | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2022-11-11 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14, 2023
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8F56
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![BU of 8f56 by Molmil](/molmil-images/mine/8f56) | |
8F4N
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![BU of 8f4n by Molmil](/molmil-images/mine/8f4n) | Dimer of aminoglycoside efflux pump AcrD | Descriptor: | Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2022-11-11 | Release date: | 2022-12-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14, 2023
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6KZC
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![BU of 6kzc by Molmil](/molmil-images/mine/6kzc) | crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide | Descriptor: | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide, NT-3 growth factor receptor | Authors: | Zhang, Z.M, Wang, Y. | Deposit date: | 2019-09-23 | Release date: | 2019-10-09 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem., 179, 2019
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6K0Z
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![BU of 6k0z by Molmil](/molmil-images/mine/6k0z) | Substrate bound state of Staphylococcus Aureus AldH | Descriptor: | 1,2-ETHANEDIOL, Aldehyde dehydrogenase, GLYCEROL | Authors: | Zhang, Z, Tao, X. | Deposit date: | 2019-05-08 | Release date: | 2020-05-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4967258 Å) | Cite: | Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase CCS Chemistry, 2, 2020
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3TBL
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![BU of 3tbl by Molmil](/molmil-images/mine/3tbl) | Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation | Descriptor: | Proliferating cell nuclear antigen, Ubiquitin | Authors: | Zhang, Z, Lee, M, Lee, E, Zhang, S. | Deposit date: | 2011-08-07 | Release date: | 2012-05-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.903 Å) | Cite: | Structure of monoubiquitinated PCNA: Implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle, 11, 2012
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5W3X
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![BU of 5w3x by Molmil](/molmil-images/mine/5w3x) | Crystal structure of PopP2 in complex with IP6, AcCoA and the WRKY domain of RRS1-R . | Descriptor: | ACETYL COENZYME *A, Disease resistance protein RRS1, GLYCEROL, ... | Authors: | Zhang, Z.M, Gao, L, Song, J. | Deposit date: | 2017-06-08 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of host substrate acetylation by a YopJ family effector. Nat Plants, 3, 2017
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1BG5
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![BU of 1bg5 by Molmil](/molmil-images/mine/1bg5) | CRYSTAL STRUCTURE OF THE ANKYRIN BINDING DOMAIN OF ALPHA-NA,K-ATPASE AS A FUSION PROTEIN WITH GLUTATHIONE S-TRANSFERASE | Descriptor: | FUSION PROTEIN OF ALPHA-NA,K-ATPASE WITH GLUTATHIONE S-TRANSFERASE | Authors: | Zhang, Z, Devarajan, P, Morrow, J.S. | Deposit date: | 1998-06-05 | Release date: | 1999-01-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the ankyrin-binding domain of alpha-Na,K-ATPase. J.Biol.Chem., 273, 1998
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6LW1
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![BU of 6lw1 by Molmil](/molmil-images/mine/6lw1) | Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | Descriptor: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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8X61
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![BU of 8x61 by Molmil](/molmil-images/mine/8x61) | Cryo-EM structure of ATP-bound FtsE(E163Q)X | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX | Authors: | Zhang, Z.Y, Chen, Y.T. | Deposit date: | 2023-11-20 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structure of ATP-bound FtsE(E163Q)X To Be Published
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3G0D
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![BU of 3g0d by Molmil](/molmil-images/mine/3g0d) | Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 2 | Descriptor: | 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L. | Deposit date: | 2009-01-27 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. J.Med.Chem., 54, 2011
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3G0G
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![BU of 3g0g by Molmil](/molmil-images/mine/3g0g) | Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinone inhibitor 3 | Descriptor: | 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1(6H)-yl}methyl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L. | Deposit date: | 2009-01-27 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. J.Med.Chem., 54, 2011
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3G0B
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![BU of 3g0b by Molmil](/molmil-images/mine/3g0b) | Crystal structure of dipeptidyl peptidase IV in complex with TAK-322 | Descriptor: | 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, Z, Wallace, M.B, Feng, J, Stafford, J.A, Kaldor, S.W, Shi, L, Skene, R.J, Aertgeerts, K, Lee, B, Jennings, A, Xu, R, Kassel, D, Webb, D.R, Gwaltney, S.L. | Deposit date: | 2009-01-27 | Release date: | 2010-02-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. J.Med.Chem., 54, 2011
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3D8V
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![BU of 3d8v by Molmil](/molmil-images/mine/3d8v) | |