6ID1
 
 | | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | 登録日 | 2018-09-07 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6IMO
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | (1S)-1-[(1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | | 登録日 | 2018-10-23 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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6INM
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | | 登録日 | 2018-10-26 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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2B5X
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2B5Y
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6INK
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | | 登録日 | 2018-10-25 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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6ICZ
 | | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | 登録日 | 2018-09-07 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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4DXW
 | | Crystal structure of NavRh, a voltage-gated sodium channel | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | | 著者 | Zhang, X, Ren, W.L, Yan, C.Y, Wang, J.W, Yan, N. | | 登録日 | 2012-02-28 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | | 主引用文献 | Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
Nature, 486, 2012
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6J4J
 | | soybean seed H-2 ferritin | | 分子名称: | Ferritin, MAGNESIUM ION | | 著者 | Zhang, X, Zang, J, Chen, H, Zhao, G. | | 登録日 | 2019-01-09 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | Thermostability of protein nanocages: the effect of natural extra peptide on the exterior surface.
Rsc Adv, 9, 2019
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5V56
 | | 2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | | 著者 | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | | 登録日 | 2017-03-13 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
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5V57
 | | 3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | | 著者 | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | | 登録日 | 2017-03-13 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
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6J4A
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5T2C
 | | CryoEM structure of the human ribosome at 3.6 Angstrom resolution | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Zhang, X, Lai, M, Zhou, Z.H. | | 登録日 | 2016-08-23 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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6IMB
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | | 著者 | Zhang, X, Su, H, Xu, Y. | | 登録日 | 2018-10-22 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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6IMD
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | | 著者 | Zhang, X, Su, H, Xu, Y. | | 登録日 | 2018-10-22 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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2MQ0
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c | | 分子名称: | Myosin-binding protein C, cardiac-type | | 著者 | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | 登録日 | 2014-06-10 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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6IMI
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 6-ethoxy-7-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | | 著者 | Zhang, X, Su, H, Xu, Y. | | 登録日 | 2018-10-23 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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5T2A
 | | CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution | | 分子名称: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Zhang, X, Lai, M, Zhou, Z.H. | | 登録日 | 2016-08-23 | | 公開日 | 2017-01-25 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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2MQ3
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c with a hypertrophic cardiomyopathy-related mutation R502W. | | 分子名称: | Myosin-binding protein C, cardiac-type | | 著者 | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | 登録日 | 2014-06-12 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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2Q12
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8YE5
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3F4M
 | | Crystal structure of TIPE2 | | 分子名称: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | | 著者 | Zhang, X, Wang, J, Shi, Y. | | 登録日 | 2008-11-01 | | 公開日 | 2009-03-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Crystal structure of TIPE2 provides insights into immune homeostasis
Nat.Struct.Mol.Biol., 16, 2009
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6LRM
 | | Crystal structure of PDE4D catalytic domain in complex with arctigenin | | 分子名称: | 1,2-ETHANEDIOL, Arctigenin, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Li, M.J, Xu, Y.C. | | 登録日 | 2020-01-16 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation.
J Adv Res, 33, 2021
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2GS2
 | | Crystal Structure of the active EGFR kinase domain | | 分子名称: | Epidermal growth factor receptor | | 著者 | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | 登録日 | 2006-04-25 | | 公開日 | 2006-06-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
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2GS6
 | | Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate | | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, Peptide, ... | | 著者 | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | 登録日 | 2006-04-25 | | 公開日 | 2006-06-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
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