6LRM
Crystal structure of PDE4D catalytic domain in complex with arctigenin
Summary for 6LRM
Entry DOI | 10.2210/pdb6lrm/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde4d, inhibitor, complex structure, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82730.73 |
Authors | Zhang, X.L.,Li, M.J.,Xu, Y.C. (deposition date: 2020-01-16, release date: 2021-04-14, Last modification date: 2023-11-29) |
Primary citation | Li, H.,Zhang, X.,Xiang, C.,Feng, C.,Fan, C.,Liu, M.,Lu, H.,Su, H.,Zhou, Y.,Qi, Q.,Xu, Y.,Tang, W. Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation. J Adv Res, 33:241-251, 2021 Cited by PubMed: 34603793DOI: 10.1016/j.jare.2021.02.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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