3VPO
 
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | Descriptor: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | Authors: | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | Deposit date: | 2012-03-05 | | Release date: | 2013-03-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Essential role of E106 in the proton-coupled electron transfer in human
to be published
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7WCY
 | | Crystal Structure of H-2Kb with Cryptosporidium parvum gp40/15 epitope | | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Wang, Y.L, Gao, M.H, Zhang, L.X, Fan, S.H. | | Deposit date: | 2021-12-20 | | Release date: | 2022-12-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural Analyses of a Dominant Cryptosporidium parvum Epitope Presented by H-2K b Offer New Options To Combat Cryptosporidiosis.
Mbio, 14, 2023
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3VPN
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | Descriptor: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | Authors: | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | Deposit date: | 2012-03-05 | | Release date: | 2013-03-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Essential role of E106 in the proton-coupled electron transfer in human
to be published
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7FHA
 | | Crystal structure of the ATP sulfurylase domain of human PAPSS2 in complex with APS | | Descriptor: | ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, POTASSIUM ION, ... | | Authors: | Zhang, P, Zhang, L, Zhang, L. | | Deposit date: | 2021-07-29 | | Release date: | 2021-12-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.
Biochem.Biophys.Res.Commun., 586, 2022
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7FH3
 | | Crystal structure of the ATP sulfurylase domain of human PAPSS2 | | Descriptor: | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2, SULFATE ION, beta-D-glucopyranose | | Authors: | Zhang, P, Zhang, L, Zhang, L. | | Deposit date: | 2021-07-29 | | Release date: | 2021-12-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.
Biochem.Biophys.Res.Commun., 586, 2022
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3V35
 | | Aldose reductase complexed with a nitro compound | | Descriptor: | 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate, Aldose reductase, DIMETHYLFORMAMIDE, ... | | Authors: | Zheng, X, Zhang, L, Chen, Y, Luo, H, Hu, X. | | Deposit date: | 2011-12-13 | | Release date: | 2012-08-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
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7Y4H
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3TBM
 | | Crystal structure of a type 4 CDGSH iron-sulfur protein. | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, L(+)-TARTARIC ACID, NONAETHYLENE GLYCOL, ... | | Authors: | Lin, J, Zhang, L, Ye, K. | | Deposit date: | 2011-08-07 | | Release date: | 2011-10-05 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.797 Å) | | Cite: | Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.
Plos One, 6, 2011
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7E6G
 | | Crystal structure of diguanylate cyclase SiaD in complex with its activator SiaC from Pseudomonas aeruginosa | | Descriptor: | DUF1987 domain-containing protein, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Zhou, J.S, Zhang, L, Zhang, L. | | Deposit date: | 2021-02-22 | | Release date: | 2021-09-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa .
Elife, 10, 2021
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7VS3
 | | The crystal structure of rat calcium-dependent activator protein for secretion (CAPS) C2PH | | Descriptor: | Calcium-dependent secretion activator 1, SULFATE ION | | Authors: | Zhou, H, Wei, Z.Q, Zhang, L, Ren, Y.J, Ma, C. | | Deposit date: | 2021-10-25 | | Release date: | 2023-02-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | The C 2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca 2+ -regulated exocytosis.
Structure, 31, 2023
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8A4T
 | | crystal structures of diastereomer (S,S,S)-13b (13b-K) in complex with the SARS-CoV-2 Mpro | | Descriptor: | 3C-like proteinase nsp5, CHLORIDE ION, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | | Authors: | Ibrahim, M, Hilgenfeld, R, Zhang, L. | | Deposit date: | 2022-06-13 | | Release date: | 2022-10-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.
J.Med.Chem., 65, 2022
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8J8K
 | | Membrane bound PRTase, C3 symmetry, acceptor bound | | Descriptor: | Decaprenyl-phosphate phosphoribosyltransferase, MONO-TRANS, OCTA-CIS DECAPRENYL-PHOSPHATE | | Authors: | Wu, F.Y, Gao, S, Zhang, L, Rao, Z.H. | | Deposit date: | 2023-05-01 | | Release date: | 2024-02-07 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis.
Nat Microbiol, 9, 2024
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8K1P
 | | mycobacterial efflux pump, ADP+vanadate bound state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | mycobacterial efflux pump, ADP+vanadate bound state
To Be Published
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8K1O
 | | mycobacterial efflux pump, AMPPNP bound state | | Descriptor: | CARDIOLIPIN, MAGNESIUM ION, Multidrug efflux system ATP-binding protein Rv1218c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | mycobacterial efflux pump, AMPPNP bound state
To Be Published
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8K1M
 | | mycobacterial efflux pump, apo state | | Descriptor: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CARDIOLIPIN, Multidrug efflux system ATP-binding protein Rv1218c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | mycobacterial efflux pump, apo state
To Be Published
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8K1N
 | | mycobacterial efflux pump, substrate-bound state | | Descriptor: | CARDIOLIPIN, Multidrug efflux system ATP-binding protein Rv1218c, Multidrug efflux system permease protein Rv1217c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | mycobacterial efflux pump, substrate-bound state
To Be Published
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7EBS
 | | Crystal structure of juvenile hormone acid methyltransferase JHAMT from silkworm | | Descriptor: | Juvenile hormone acid methyltransferase | | Authors: | Guo, P.C, Zhang, Y.S, Zhang, L, Xu, H.Y, Xia, Q.Y. | | Deposit date: | 2021-03-11 | | Release date: | 2021-09-29 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase.
J.Biol.Chem., 297, 2021
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7W5P
 | | Crystal Structure of the dioxygenase CcTet from Coprinopsis cinereain bound to 12bp N6-methyldeoxyadenine (6mA) containing duplex DNA | | Descriptor: | CcTet, DNA, DNA (12-MER), ... | | Authors: | Mu, Y.J, Zhang, L, Zhang, L. | | Deposit date: | 2021-11-30 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA.
Nat.Chem.Biol., 18, 2022
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3V36
 | | Aldose reductase complexed with glceraldehyde | | Descriptor: | Aldose reductase, D-Glyceraldehyde, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Zheng, X, Zhang, L, Chen, Y, Luo, H, Hu, X. | | Deposit date: | 2011-12-13 | | Release date: | 2012-08-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
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8FML
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4MKI
 | | Cobalt transporter ATP-binding subunit | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Energy-coupling factor transporter ATP-binding protein EcfA2, SULFATE ION | | Authors: | Yu, Y, Zhang, L, Chai, C.L, Heymann, D. | | Deposit date: | 2013-09-05 | | Release date: | 2013-10-30 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for a homodimeric ATPase subunit of an ECF transporter
Protein Cell, 4, 2013
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7XSP
 | | Structure of gRAMP-target RNA | | Descriptor: | RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ... | | Authors: | Feng, Y, Zhang, L.X. | | Deposit date: | 2022-05-15 | | Release date: | 2022-11-09 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
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3WQL
 | | Crystal structure of Rv3378c with Mg2+ and PPi | | Descriptor: | Diterpene synthase, MAGNESIUM ION | | Authors: | Chan, H.C, Feng, X, Ko, T.P, Huang, C.H, Hu, Y, Zheng, Y, Bogue, S, Nakano, C, Hoshino, T, Zhang, L, Lv, P, Liu, W, Crick, D.C, Liang, P.H, Wang, A.H, Oldfield, E, Guo, R.T. | | Deposit date: | 2014-01-28 | | Release date: | 2014-02-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
J.Am.Chem.Soc., 136, 2014
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7YHS
 | | Structure of Csy-AcrIF4-dsDNA | | Descriptor: | AcrIF4, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | | Authors: | Feng, Y, Zhang, L.X. | | Deposit date: | 2022-07-14 | | Release date: | 2023-03-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage.
J.Biol.Chem., 298, 2022
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8A4Q
 | | crystal structures of diastereomer (R,S,S)-13b (13b-H) in complex with the SARS-CoV-2 Mpro. | | Descriptor: | 3C-like proteinase nsp5, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Ibrahim, M, Hilgenfeld, R, Zhang, L. | | Deposit date: | 2022-06-13 | | Release date: | 2022-10-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.
J.Med.Chem., 65, 2022
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