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PDB: 703 件
3HI6
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Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57
分子名称: Heavy chain of Fab fragment of AL-57 against alpha L I domain, Integrin alpha-L, MANGANESE (II) ION, ...
著者Zhang, H, Wang, J.
登録日2009-05-19
公開日2009-09-22
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.
Proc.Natl.Acad.Sci.USA, 106, 2009
1REO
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BU of 1reo by Molmil
L-amino acid oxidase from Agkistrodon halys pallas
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AHPLAAO, CITRIC ACID, ...
著者Zhang, H, Teng, M, Niu, L, Wang, Y, Wang, Y, Liu, Q, Huang, Q, Hao, Q, Dong, Y, Liu, P.
登録日2003-11-07
公開日2004-05-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom.
Acta Crystallogr.,Sect.D, 60, 2004
1TDO
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L-amino acid oxidae from Agkistrodon halys in complex with L-phenylalanine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid oxidase, ...
著者Zhang, H, Teng, M, Niu, L.
登録日2004-05-23
公開日2004-06-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of L-amino acid oxidase in complexes with substrates and substrate analogue
To be Published
1TDK
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BU of 1tdk by Molmil
L-amino acid oxidase from Agkistrodon halys in complex with suicide substrate L-vinylglycine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, L-VINYLGLYCINE, ...
著者Zhang, H, Teng, M, Niu, L.
登録日2004-05-22
公開日2004-06-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of L-amino acid oxidase in complexes with substrates and substrate analogue
To be Published
1TDN
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BU of 1tdn by Molmil
L-amino acid oxidase from Agkistrodon halys in complex with L-leucine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid oxidase, ...
著者Zhang, H, Teng, M, Niu, L.
登録日2004-05-23
公開日2004-06-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of L-amino acid oxidase in complex with substrates and substrate analogue
To be Published
1UYS
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BU of 1uys by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop
分子名称: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, ACETYL-COA CARBOXYLASE
著者Zhang, H, Tweel, B, Tong, L.
登録日2004-03-02
公開日2004-03-29
最終更新日2012-06-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
1UYT
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Acetyl-CoA carboxylase carboxyltransferase domain
分子名称: ACETYL-COA CARBOXYLASE
著者Zhang, H, Tweel, B, Tong, L.
登録日2004-03-02
公開日2004-03-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop.
Proc.Natl.Acad.Sci.USA, 101, 2004
1UYR
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BU of 1uyr by Molmil
Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop
分子名称: 2-[4-(2,4-DICHLOROPHENOXY)PHENOXY]PROPANOIC ACID, ACETYL-COA CARBOXYLASE
著者Zhang, H, Tweel, B, Tong, L.
登録日2004-03-02
公開日2004-03-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
1UYV
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Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant
分子名称: ACETYL-COA CARBOXYLASE
著者Zhang, H, Tweel, B, Tong, L.
登録日2004-03-02
公開日2004-03-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
3NSN
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BU of 3nsn by Molmil
Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with TMG-chitotriomycin
分子名称: 2-deoxy-2-(trimethylammonio)-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosaminidase
著者Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X.
登録日2010-07-02
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme
J.Biol.Chem., 286, 2011
3NSM
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Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 from Ostrinia furnacalis
分子名称: N-acetylglucosaminidase
著者Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X.
登録日2010-07-02
公開日2010-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme
J.Biol.Chem., 286, 2011
5ZGP
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BU of 5zgp by Molmil
Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin
分子名称: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Zhang, H, Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGF
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Crystal structure of NDM-1 Q123G mutant
分子名称: HYDROXIDE ION, Metallo-beta-lactamase type 2, ZINC ION
著者Zhang, H, Hao, Q.
登録日2018-03-08
公開日2018-08-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZGI
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BU of 5zgi by Molmil
Crystal structure of NDM-1 at pH6.5 (Succinate) with 1 molecule per asymmetric unit
分子名称: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
著者Zhang, H, Hao, Q.
登録日2018-03-09
公開日2018-08-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
5ZIA
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BU of 5zia by Molmil
Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide
分子名称: Heavy chain of CBTAU-24.1 antibody, Light chain (kappa) of CBTAU-24.1 antibody, phosphorylated tau peptide
著者Zhang, H, Wilson, I.A.
登録日2018-03-14
公開日2018-10-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.603 Å)
主引用文献Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody.
Structure, 26, 2018
5ZGX
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BU of 5zgx by Molmil
Crystal structure of NDM-1 at pH7.5 (Succinate) with 1 molecule per asymmetric unit
分子名称: 1,2-ETHANEDIOL, HYDROXIDE ION, Metallo-beta-lactamase type 2, ...
著者Zhang, H, Hao, Q.
登録日2018-03-10
公開日2018-08-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
3OZO
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BU of 3ozo by Molmil
Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT
分子名称: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, N-acetylglucosaminidase
著者Zhang, H, Liu, T, Liu, F, Shen, X, Yang, Q.
登録日2010-09-27
公開日2011-09-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT
To be Published
6B57
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tudor in complex with ligand
分子名称: Tudor and KH domain-containing protein, UNKNOWN ATOM OR ION
著者Zhang, H, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2017-09-28
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3OZP
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BU of 3ozp by Molmil
Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with PUGNAc
分子名称: N-acetylglucosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
著者Zhang, H, Liu, T, Liu, F, Shen, X, Yang, Q.
登録日2010-09-27
公開日2011-08-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases
Biochem.J., 438, 2011
8X73
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Crystal structure of Peroxiredoxin I in complex with compound 19-069
分子名称: Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate
著者Zhang, H, Luo, C.
登録日2023-11-22
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
8X71
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Crystal structure of Peroxiredoxin I in complex with compound 19-064
分子名称: Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate
著者Zhang, H, Luo, C.
登録日2023-11-22
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
8GS4
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BU of 8gs4 by Molmil
Cryo-EM structure of human Neuroligin 2
分子名称: Neuroligin-2
著者Zhang, H, Zhang, Z, Hou, M.
登録日2022-09-04
公開日2023-03-01
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022
8GS3
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Cryo-EM structure of human Neuroligin 3
分子名称: Neuroligin-3
著者Zhang, H, Zhang, Z, Hou, M.
登録日2022-09-04
公開日2023-09-20
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.
Front Endocrinol, 13, 2022
4TMF
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BU of 4tmf by Molmil
Crystal structure of human CD38 in complex with hydrolysed compound JMS713
分子名称: 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D- ribofuranose, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
著者Zhang, H, Swarbrick, J, Potter, B, Hao, Q.
登録日2014-06-01
公開日2015-05-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J.Med.Chem., 57, 2014
5GRM
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BU of 5grm by Molmil
Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
分子名称: Stimulator of interferon genes protein, cGAMP
著者Zhang, H, Han, M.J, Tao, J.L, Ye, Z.Y, Du, X.X, Deng, M.J, Zhang, X.Y, Li, L.F, Jiang, Z.F, Su, X.D.
登録日2016-08-11
公開日2017-10-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
To Be Published

224004

件を2024-08-21に公開中

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