4KV1
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5ZIO
| Crystal structure of NDM-1 in complex with L-captopril | Descriptor: | L-CAPTOPRIL, Metallo-beta-lactamase type 2, ZINC ION | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-16 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors Bioorg.Med.Chem., 29, 2020
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5ZJ2
| Crystal structure of NDM-1 in complex with D-captopril | Descriptor: | 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, Metallo-beta-lactamase type 2, ZINC ION | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-18 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors Bioorg.Med.Chem., 29, 2020
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5Z4P
| Crystal structure of tubulin-stathmin-TTL-Compound TCA complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6,7,8-trimethoxy-1-(4-methoxyphenyl)-4,5-dihydro-2~{H}-benzo[e]indazole, CALCIUM ION, ... | Authors: | Zhang, H, Luo, C. | Deposit date: | 2018-01-12 | Release date: | 2019-01-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and Design of novel Tubulin inhibitors To Be Published
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5ZGP
| Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-10 | Release date: | 2018-08-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
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5ZGZ
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5ZGF
| Crystal structure of NDM-1 Q123G mutant | Descriptor: | HYDROXIDE ION, Metallo-beta-lactamase type 2, ZINC ION | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-08 | Release date: | 2018-08-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
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3R29
| Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 | Descriptor: | Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha | Authors: | Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. | Deposit date: | 2011-03-14 | Release date: | 2011-05-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem., 286, 2011
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3R2A
| Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein | Descriptor: | 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Nuclear receptor corepressor 2, Retinoic acid receptor RXR-alpha | Authors: | Zhang, H, Chen, L, Chen, J, Jiang, H, Shen, X. | Deposit date: | 2011-03-14 | Release date: | 2011-05-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem., 286, 2011
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3T5T
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3T7D
| Vall from streptomyces hygroscopicus in complex with trehalose | Descriptor: | IMIDAZOLE, MAGNESIUM ION, Putative glycosyltransferase, ... | Authors: | Zhang, H, Zheng, L, Qian, H, Chen, J. | Deposit date: | 2011-07-29 | Release date: | 2012-08-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for the substrate specificity of ValL To be Published
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3R5M
| Crystal structure of RXRalphaLBD complexed with the agonist magnolol | Descriptor: | 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | Authors: | Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. | Deposit date: | 2011-03-18 | Release date: | 2012-02-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One, 6, 2011
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6JOM
| Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae | Descriptor: | 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, Lipoate--protein ligase | Authors: | Zhang, H, Chen, H, Ma, G. | Deposit date: | 2019-03-22 | Release date: | 2020-03-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae. Front Cell Infect Microbiol, 10, 2020
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8GN8
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3RAJ
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5J5L
| CRYSTAL STRUCTURE OF AFMP4P IN COMPLEX WITH ARACHIDONIC ACID | Descriptor: | ARACHIDONIC ACID, Uncharacterized protein | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2016-04-03 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Novel Class Of Virulence Factors In Penicillium Marneffei And Aspergillus Fumigatus Enhances Intracellular Survival In Monocytes By Arachidonic Acid Binding To Be Published
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8JQK
| Crystal structure of a carbonyl reductase SSCR mutant from Sporobolomyces Salmonicolor | Descriptor: | Aldehyde reductase 2 | Authors: | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | Deposit date: | 2023-06-14 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
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8JQJ
| Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor | Descriptor: | Aldehyde reductase 2 | Authors: | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | Deposit date: | 2023-06-14 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
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3R5N
| Crystal structure of PPARgammaLBD complexed with the agonist magnolol | Descriptor: | 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Peroxisome proliferator-activated receptor gamma | Authors: | Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X. | Deposit date: | 2011-03-18 | Release date: | 2012-02-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One, 6, 2011
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2N28
| Solid-state NMR structure of Vpu | Descriptor: | Protein Vpu | Authors: | Zhang, H, Lin, E.C, Tian, Y, Das, B.B, Opella, S.J. | Deposit date: | 2015-05-01 | Release date: | 2015-09-30 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Structural determination of virus protein U from HIV-1 by NMR in membrane environments. Biochim.Biophys.Acta, 1848, 2015
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3NSN
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with TMG-chitotriomycin | Descriptor: | 2-deoxy-2-(trimethylammonio)-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosaminidase | Authors: | Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X. | Deposit date: | 2010-07-02 | Release date: | 2010-11-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem., 286, 2011
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7EJ3
| UTP cyclohydrolase | Descriptor: | DIPHOSPHATE, GLYCINE, GTP cyclohydrolase II, ... | Authors: | Zhang, H, Zhang, Y, Yuchi, Z. | Deposit date: | 2021-04-01 | Release date: | 2022-09-21 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and biochemical investigation of UTP cyclohydrolase Acs Catalysis, 2021
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3NSM
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 from Ostrinia furnacalis | Descriptor: | N-acetylglucosaminidase | Authors: | Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X. | Deposit date: | 2010-07-02 | Release date: | 2010-11-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem., 286, 2011
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6JZZ
| The crystal structure of AAR-C294S in complex with ADO. | Descriptor: | Aldehyde decarbonylase, FE (II) ION, HEXADECAN-1-OL, ... | Authors: | Zhang, H.M, Li, M, Gao, Y. | Deposit date: | 2019-05-04 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.011 Å) | Cite: | Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase. Nat Commun, 11, 2020
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6JZY
| Crystal structure of AAR with NADPH and stearyl in complex with ADO binding a long chain carbohydrate | Descriptor: | Aldehyde decarbonylase, FE (II) ION, HEXADECAN-1-OL, ... | Authors: | Zhang, H.M, Li, M, Gao, Y. | Deposit date: | 2019-05-04 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase. Nat Commun, 11, 2020
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