7WQS
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![BU of 7wqs by Molmil](/molmil-images/mine/7wqs) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25 | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-26 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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7WQM
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![BU of 7wqm by Molmil](/molmil-images/mine/7wqm) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 24 | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-25 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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4N8R
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![BU of 4n8r by Molmil](/molmil-images/mine/4n8r) | Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 | 分子名称: | 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | 登録日 | 2013-10-17 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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7VKM
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![BU of 7vkm by Molmil](/molmil-images/mine/7vkm) | Crystal structure of TrkA (G595R) kinase domain | 分子名称: | Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKO
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![BU of 7vko by Molmil](/molmil-images/mine/7vko) | Crystal structure of TrkA kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKN
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![BU of 7vkn by Molmil](/molmil-images/mine/7vkn) | Crystal structure of TrkA (G595R) kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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4N5G
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![BU of 4n5g by Molmil](/molmil-images/mine/4n5g) | Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 | 分子名称: | 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | 登録日 | 2013-10-09 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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7EW6
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![BU of 7ew6 by Molmil](/molmil-images/mine/7ew6) | Barley photosystem I-LHCI-Lhca5 supercomplex | 分子名称: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Wang, W.D, Shen, L, Tang, K, Han, G.Y, Zhang, X, Shen, J.R. | 登録日 | 2021-05-24 | 公開日 | 2021-12-22 | 最終更新日 | 2022-02-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare. Nature, 601, 2022
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7EU3
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![BU of 7eu3 by Molmil](/molmil-images/mine/7eu3) | Chloroplast NDH complex | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | 著者 | Wang, W.D, Shen, L, Tang, K, Han, G.Y, Zhang, X, Shen, J.R. | 登録日 | 2021-05-15 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-09 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare. Nature, 601, 2022
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7EWK
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![BU of 7ewk by Molmil](/molmil-images/mine/7ewk) | Barley photosystem I-LHCI-Lhca6 supercomplex | 分子名称: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Wang, W.D, Shen, L, Tang, K, Han, G.Y, Zhang, X, Shen, J.R. | 登録日 | 2021-05-25 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare. Nature, 601, 2022
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7X3L
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![BU of 7x3l by Molmil](/molmil-images/mine/7x3l) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044 | 分子名称: | (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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7X3M
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![BU of 7x3m by Molmil](/molmil-images/mine/7x3m) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045 | 分子名称: | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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6IZK
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![BU of 6izk by Molmil](/molmil-images/mine/6izk) | Structural characterization of mutated NreA protein in nitrate binding site from Staphylococcus aureus | 分子名称: | CHLORIDE ION, IMIDAZOLE, L(+)-TARTARIC ACID, ... | 著者 | Sangare, L, Chen, W, Wang, C, Chen, X, Wu, M, Zhang, X, Zang, J. | 登録日 | 2018-12-19 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structural characterization of mutated NreA protein in nitrate binding site from Staphylococcus aureus To Be Published
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7FBI
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![BU of 7fbi by Molmil](/molmil-images/mine/7fbi) | Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 | 分子名称: | 3A3 heavy chain, 3A3 light chain, 3A5 heavy chain, ... | 著者 | Zheng, Q, Li, S, Zha, Z, Hong, J, Chen, Y, Zhang, X. | 登録日 | 2021-07-10 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5 To Be Published
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7XSN
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![BU of 7xsn by Molmil](/molmil-images/mine/7xsn) | Native Tetrahymena ribozyme conformation | 分子名称: | RNA (387-MER) | 著者 | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | 登録日 | 2022-05-14 | 公開日 | 2022-08-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSL
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![BU of 7xsl by Molmil](/molmil-images/mine/7xsl) | Misfolded Tetrahymena ribozyme conformation 2 | 分子名称: | RNA (388-MER) | 著者 | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | 登録日 | 2022-05-14 | 公開日 | 2022-08-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | 主引用文献 | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSM
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![BU of 7xsm by Molmil](/molmil-images/mine/7xsm) | Misfolded Tetrahymena ribozyme conformation 3 | 分子名称: | RNA (388-MER) | 著者 | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | 登録日 | 2022-05-14 | 公開日 | 2022-08-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | 主引用文献 | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XSK
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![BU of 7xsk by Molmil](/molmil-images/mine/7xsk) | Misfolded Tetrahymena ribozyme conformation 1 | 分子名称: | RNA (388-MER) | 著者 | Li, S, Palo, M, Pintilie, G, Zhang, X, Su, Z, Kappel, K, Chiu, W, Zhang, K, Das, R. | 登録日 | 2022-05-14 | 公開日 | 2022-08-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7W5S
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![BU of 7w5s by Molmil](/molmil-images/mine/7w5s) | A nonheme iron- and alpha-ketoglutarate- dependent halogenase that catalyzes nucleotide substrates | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FE (II) ION, ... | 著者 | Dai, L.H, Zhang, X, Hu, Y.M, Huang, J.W, Chen, C.C, Guo, R.T. | 登録日 | 2021-11-30 | 公開日 | 2022-04-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural and Functional Insights into a Nonheme Iron- and alpha-Ketoglutarate-Dependent Halogenase That Catalyzes Chlorination of Nucleotide Substrates. Appl.Environ.Microbiol., 88, 2022
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7W5T
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![BU of 7w5t by Molmil](/molmil-images/mine/7w5t) | A nonheme iron- and alpha-ketoglutarate- dependent halogenase that catalyzes nucleotide substrates | 分子名称: | 2-OXOGLUTARIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dai, L.H, Zhang, X, Hu, Y.M, Huang, J.W, Chen, C.C, Guo, R.T. | 登録日 | 2021-11-30 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structural and Functional Insights into a Nonheme Iron- and alpha-Ketoglutarate-Dependent Halogenase That Catalyzes Chlorination of Nucleotide Substrates. Appl.Environ.Microbiol., 88, 2022
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7W5V
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![BU of 7w5v by Molmil](/molmil-images/mine/7w5v) | A nonheme iron- and alpha-ketoglutarate- dependent halogenase that catalyzes nucleotide substrates | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | 著者 | Dai, L.H, Zhang, X, Hu, Y.M, Huang, J.W, Chen, C.C, Guo, R.T. | 登録日 | 2021-11-30 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural and Functional Insights into a Nonheme Iron- and alpha-Ketoglutarate-Dependent Halogenase That Catalyzes Chlorination of Nucleotide Substrates. Appl.Environ.Microbiol., 88, 2022
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7YG8
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![BU of 7yg8 by Molmil](/molmil-images/mine/7yg8) | Cryo-EM structure of Tetrahymena ribozyme conformation 5 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (387-MER), RNA (5'-R(*CP*CP*CP*UP*C)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YG9
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![BU of 7yg9 by Molmil](/molmil-images/mine/7yg9) | Cryo-EM structure of Tetrahymena ribozyme conformation 1 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (391-MER), RNA (5'-R(*CP*CP*CP*UP*CP*U)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YGC
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![BU of 7ygc by Molmil](/molmil-images/mine/7ygc) | Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (393-MER), RNA (5'-R(*CP*CP*CP*UP*CP*UP*UP*AP*AP*CP*C)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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7YGA
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![BU of 7yga by Molmil](/molmil-images/mine/7yga) | Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the second-step self-splicing | 分子名称: | MAGNESIUM ION, RNA (393-MER), RNA (5'-R(*CP*CP*CP*UP*CP*U)-3'), ... | 著者 | Li, S, Michael, Z.P, Zhang, X, Greg, P, Zhang, K. | 登録日 | 2022-07-11 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun, 14, 2023
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