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PDB: 142 件
5GQ9
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BU of 5gq9 by Molmil
Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target
分子名称: DNA (5'-D(P*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ...
著者Zhao, H, Sheng, G, Wang, Y.
登録日2016-08-06
公開日2017-08-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target
To Be Published
1MRY
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BU of 1mry by Molmil
crystal structure of an inactive akt2 kinase domain
分子名称: RAC-beta serine/threonine kinase
著者Huang, X, Begley, M, Morgenstern, K.A, Gu, Y, Rose, P, Zhao, H, Zhu, X.
登録日2002-09-18
公開日2003-09-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of an inactive akt2 kinase domain
Structure, 11, 2003
1MRV
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BU of 1mrv by Molmil
crystal structure of an inactive Akt2 kinase domain
分子名称: RAC-beta serine/threonine kinase
著者Huang, X, Begley, M, Morgenstern, K.A, Gu, Y, Rose, P, Zhao, H, Zhu, X.
登録日2002-09-18
公開日2003-09-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of an inactive akt2 kinase domain
Structure, 11, 2003
2QU6
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BU of 2qu6 by Molmil
Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor
分子名称: 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide, SULFATE ION, Vascular endothelial growth factor receptor 2
著者Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日2007-08-03
公開日2007-09-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
2QU5
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BU of 2qu5 by Molmil
Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor
分子名称: 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide, Vascular endothelial growth factor receptor 2
著者Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日2007-08-03
公開日2007-09-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
6WKV
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BU of 6wkv by Molmil
Cryo-EM structure of engineered variant of the Encapsulin from Thermotoga maritima (TmE)
分子名称: Encapsulin, FLAVIN MONONUCLEOTIDE
著者Williams, E, Jenkins, M, Zhao, H, Juneja, P, Lutz, S.
登録日2020-04-17
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Cryo-EM structure of engineered variant of the Encapsulin from Thermotoga maritima (TmE)
To Be Published
7YNA
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BU of 7yna by Molmil
Cryo-EM structure of Cas7-11-crRNA bound to target RNA-1
分子名称: CRISPR-associated RAMP family protein, Target RNA-1 (25-MER), crRNA (38-MER)
著者Huo, Y, Dong, Q, Zhao, H, Jiang, T.
登録日2022-07-30
公開日2023-02-01
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Nat Microbiol, 8, 2023
7YNB
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BU of 7ynb by Molmil
Cryo-EM structure of Cas7-11-crRNA bound to target RNA-2
分子名称: CRISPR-associated RAMP family protein, Target RNA-2 (28-MER), crRNA (38-MER)
著者Huo, Y, Dong, Q, Zhao, H, Jiang, T.
登録日2022-07-30
公開日2023-02-01
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Nat Microbiol, 8, 2023
7YNC
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BU of 7ync by Molmil
Cryo-EM structure of Cas7-11-crRNA bound to target RNA-3
分子名称: CRISPR-associated RAMP family protein, Target RNA-3 (28-MER), crRNA (38-MER)
著者Huo, Y, Dong, Q, Zhao, H, Jiang, T.
登録日2022-07-30
公開日2023-02-01
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Nat Microbiol, 8, 2023
7YND
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BU of 7ynd by Molmil
Cryo-EM structure of Cas7-11-crRNA-Csx29 ternary complex
分子名称: CHAT domain-containing protein, CRISPR-associated RAMP family protein, crRNA (38-MER)
著者Huo, Y, Dong, Q, Zhao, H, Jiang, T.
登録日2022-07-30
公開日2023-02-01
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Nat Microbiol, 8, 2023
7YN9
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BU of 7yn9 by Molmil
Cryo-EM structure of Cas7-11-crRNA binary complex
分子名称: CRISPR-associated RAMP family protein, crRNA
著者Huo, Y, Dong, Q, Zhao, H, Jiang, T.
登録日2022-07-30
公開日2023-02-01
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector.
Nat Microbiol, 8, 2023
5XP8
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BU of 5xp8 by Molmil
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 4A5 on the guide strand
分子名称: DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ...
著者Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
4N77
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BU of 4n77 by Molmil
Crystal structure of Cas protein
分子名称: Uncharacterized protein
著者Tian, W, Sheng, G, Zhao, H, Wang, J, Wang, Y.
登録日2013-10-15
公開日2014-10-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal strucute studies of CasD
To be Published
4N41
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BU of 4n41 by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 15-mer target DNA
分子名称: 5'-D(*AP*AP*CP*CP*TP*AP*CP*TP*GP*CP*CP*TP*CP*G)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N47
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BU of 4n47 by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 12-mer target DNA
分子名称: 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.823 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCA
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BU of 4nca by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+
分子名称: 5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-24
公開日2014-01-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.489 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCB
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BU of 4ncb by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 19-mer target DNA with Mg2+
分子名称: 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3', 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-24
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.189 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
6P05
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BU of 6p05 by Molmil
Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27
分子名称: Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide
著者Ratia, K.M, Xiong, R, Li, Y, Zhao, J, Gutgesell, L.M, Shen, Z, Dye, K, Dubrovyskyii, O, Zhao, H, Huang, F, Tonetti, D.A, Thatcher, G.R.
登録日2019-05-16
公開日2020-05-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
2RL5
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BU of 2rl5 by Molmil
Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor
分子名称: N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE, Vascular endothelial growth factor receptor 2
著者Whittington, D.A, Long, A.M, Rose, P, Zhao, H.
登録日2007-10-18
公開日2008-04-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
J.Med.Chem., 51, 2008
1NVQ
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BU of 1nvq by Molmil
The Complex Structure Of Checkpoint Kinase Chk1/UCN-01
分子名称: 7-HYDROXYSTAUROSPORINE, Peptide ASVSA, SULFATE ION, ...
著者Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B.
登録日2003-02-04
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Chk1 Inhibition by UCN-01
J.Biol.Chem., 277, 2002
1NVR
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BU of 1nvr by Molmil
The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine
分子名称: Peptide ASVSA, STAUROSPORINE, SULFATE ION, ...
著者Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B.
登録日2003-02-04
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Chk1 Inhibition by UCN-01
J.Biol.Chem., 277, 2002
1NVS
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BU of 1nvs by Molmil
The Complex Structure Of Checkpoint Kinase Chk1/SB218078
分子名称: Peptide ASVSA, REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE, SULFATE ION, ...
著者Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B.
登録日2003-02-04
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Chk1 Inhibition by UCN-01
J.Biol.Chem., 277, 2002
8CEG
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BU of 8ceg by Molmil
BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling
分子名称: CBY1-interacting BAR domain-containing protein 1
著者Kajander, T, Fudo, S, Yan, Z, Zhao, H.
登録日2023-02-01
公開日2024-02-21
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling
To Be Published
8EX8
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BU of 8ex8 by Molmil
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 2)
分子名称: Sphingosine-1-phosphate transporter SPNS2
著者Ahmed, S, Zhao, H, Dai, Y, Lee, C.H.
登録日2022-10-24
公開日2023-05-31
最終更新日2023-06-28
実験手法ELECTRON MICROSCOPY (4.17 Å)
主引用文献Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
8EX7
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BU of 8ex7 by Molmil
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 3)
分子名称: Sphingosine-1-phosphate transporter SPNS2
著者Ahmed, S, Zhao, H, Dai, Y, Lee, C.H.
登録日2022-10-24
公開日2023-05-31
最終更新日2023-06-28
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023

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件を2024-06-12に公開中

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