8YET
 
 | | Cryo EM structure of human phosphate channel XPR1 in complex with IP6 | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Solute carrier family 53 member 1 | | Authors: | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | Deposit date: | 2024-02-23 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
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8YFX
 | | Cryo EM structure of human phosphate channel XPR1 at inward-facing state | | Descriptor: | Solute carrier family 53 member 1 | | Authors: | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | Deposit date: | 2024-02-25 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
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8YFW
 | | Cryo EM structure of human phosphate channel XPR1 at intermediate state | | Descriptor: | Solute carrier family 53 member 1 | | Authors: | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | Deposit date: | 2024-02-25 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
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9IWS
 | | Cryo EM structure of human phosphate channel XPR1 in complex with IP7 | | Descriptor: | (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Solute carrier family 53 member 1 | | Authors: | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | Deposit date: | 2024-07-25 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
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6LP7
 | | Crystal structure of human DHODH in complex with inhibitor 0944 | | Descriptor: | 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2020-01-09 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6LP6
 | | Crystal structure of human DHODH in complex with inhibitor 1214 | | Descriptor: | 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2020-01-09 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.795 Å) | | Cite: | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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8J4U
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3DCG
 | | Crystal Structure of the HIV Vif BC-box in Complex with Human ElonginB and ElonginC | | Descriptor: | Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, Virion infectivity factor | | Authors: | Stanley, B.J, Ehrlich, E.S, Short, L, Yu, Y, Xiao, Z, Yu, X.-F, Xiong, Y. | | Deposit date: | 2008-06-03 | | Release date: | 2008-07-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly
J.Virol., 82, 2008
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7MEY
 | | Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron | | Descriptor: | 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... | | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | | Deposit date: | 2021-04-08 | | Release date: | 2021-11-24 | | Last modified: | 2021-12-22 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination.
Nature, 600, 2021
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7MEX
 | | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | | Deposit date: | 2021-04-08 | | Release date: | 2021-11-24 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination.
Nature, 600, 2021
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4WVR
 | | Crystal structure of Dscam1 Ig7 domain, isoform 5 | | Descriptor: | Down syndrome cell adhesion molecule, isoform AK | | Authors: | Chen, Q, Yu, Y, Li, S, Cheng, L. | | Deposit date: | 2014-11-07 | | Release date: | 2015-11-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.948 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X83
 | | Crystal structure of Dscam1 isoform 7.44, N-terminal four Ig domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-10 | | Release date: | 2015-12-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.902 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9B
 | | Crystal structure of Dscam1 isoform 4.44, N-terminal four Ig domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.44, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-11 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9G
 | | Crystal structure of Dscam1 isoform 6.44, N-terminal four Ig domains | | Descriptor: | Down Syndrome Cell Adhesion Molecule isoform 6.44, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-11 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.403 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4XB7
 | | Crystal structure of Dscam1 isoform 4.4, N-terminal four Ig domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.4, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-16 | | Release date: | 2015-12-16 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (4.004 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9I
 | | Crystal structure of Dscam1 isoform 9.44, N-terminal four Ig domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down Syndrome Cell Adhesion Molecule, isoform 9.44, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, cheng, L. | | Deposit date: | 2014-12-11 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.904 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4XB8
 | | Crystal structure of Dscam1 isoform 9.44, N-terminal four Ig domains (with zinc) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down Syndrome Cell Adhesion Molecule, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, cheng, L. | | Deposit date: | 2014-12-16 | | Release date: | 2015-12-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.202 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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8RXR
 | | Crystal structure of VPS34 in complex with inhibitor SB02024 | | Descriptor: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | | Deposit date: | 2024-02-07 | | Release date: | 2024-03-20 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol, 18, 2024
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4XHQ
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2F07
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4X9F
 | | Crystal structure of Dscam1 isoform 6.9, N-terminal four Ig domains | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Down Syndrome Cell Adhesion Molecule isoform 6.9, GLYCEROL, ... | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-11 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X5L
 | | Crystal structure of Dscam1 Ig7 domain, isoform 9 | | Descriptor: | Down syndrome cell adhesion molecule, isoform AM, SODIUM ION | | Authors: | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | Deposit date: | 2014-12-05 | | Release date: | 2015-12-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.374 Å) | | Cite: | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4EJQ
 | | Crystal structure of KIF1A C-CC1-FHA | | Descriptor: | Kinesin-like protein KIF1A | | Authors: | Huo, L, Yue, Y, Ren, J, Yu, J, Liu, J, Yu, Y, Ye, F, Xu, T, Zhang, M, Feng, W. | | Deposit date: | 2012-04-06 | | Release date: | 2012-10-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.893 Å) | | Cite: | The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A
Structure, 20, 2012
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7KQY
 | | Crystal Structure and Characterization of Human Heavy-Chain only Antibodies reveals a novel, stable dimeric structure similar to Monoclonal Antibodies | | Descriptor: | Heavy-Chain only Human Antibodies | | Authors: | Bahmanjah, S, Mieczkowski, C, Yu, Y, Baker, J, Raghunathan, G, Tomazela, D, Hsieh, M, Mccoy, M, Strickland, C, Fayadat-Dilman, L. | | Deposit date: | 2020-11-18 | | Release date: | 2020-12-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.913 Å) | | Cite: | Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies.
Antibodies, 9, 2020
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8K3S
 | | Structure of PKD2-F604P complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | | Authors: | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | Deposit date: | 2023-07-16 | | Release date: | 2024-04-03 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
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