8SXN
| Structure of NLRP3 and NEK7 complex | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-22 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.04 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
|
|
5W5G
| Structure of Human Sts-1 histidine phosphatase domain | Descriptor: | Ubiquitin-associated and SH3 domain-containing protein B | Authors: | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | Deposit date: | 2017-06-15 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry, 56, 2017
|
|
5WDI
| Structure of Human Sts-2 histidine phosphatase domain | Descriptor: | SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein A | Authors: | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | Deposit date: | 2017-07-05 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry, 56, 2017
|
|
8PE9
| Complex between DDR1 DS-like domain and PRTH-101 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Liu, J, Chiang, H, Xiong, W, Laurent, V, Griffiths, S.C, Duelfer, J, Deng, H, Sun, X, Yin, Y.W, Li, W, Audoly, L.P, An, Z, Schuerpf, T, Li, R, Zhang, N. | Deposit date: | 2023-06-13 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.152 Å) | Cite: | A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11, 2023
|
|
5VR6
| Structure of Human Sts-1 histidine phosphatase domain with sulfate bound | Descriptor: | SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein B | Authors: | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | Deposit date: | 2017-05-10 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry, 56, 2017
|
|
5EEA
| Structure of HOXB13-DNA(CAA) complex | Descriptor: | DNA (5'-D(P*GP*GP*AP*CP*CP*CP*AP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*TP*TP*GP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13 | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-22 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.195 Å) | Cite: | Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima. Elife, 7, 2018
|
|
5EDN
| Structure of HOXB13-DNA(TCG) complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(P*GP*GP*AP*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), ... | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-21 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima. Elife, 7, 2018
|
|
5HOD
| Structure of LHX4 transcription factor complexed with DNA | Descriptor: | DNA (5'-D(P*AP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*GP*TP*AP*AP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*TP*TP*AP*CP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*T)-3'), LIM/homeobox protein Lhx4 | Authors: | Morgunova, E, Yin, Y, Popov, A, Taipale, J. | Deposit date: | 2016-01-19 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.682 Å) | Cite: | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
|
|
6IG2
| Structure of mitochondrial CDP-DAG synthase Tam41 complexed with CTP, delta 74, F240A | Descriptor: | CYTIDINE-5'-TRIPHOSPHATE, Phosphatidate cytidylyltransferase, mitochondrial | Authors: | Jiao, H.Z, Yin, Y, Liu, Z.F. | Deposit date: | 2018-09-23 | Release date: | 2019-07-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.882 Å) | Cite: | Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site. Structure, 27, 2019
|
|
6INE
| Crystal Structure of human ASH1L-MRG15 complex | Descriptor: | GLYCEROL, Histone-lysine N-methyltransferase ASH1L, Mortality factor 4-like protein 1, ... | Authors: | Hou, P, Huang, C, Liu, C.P, Yu, T, Yin, Y, Zhu, B, Xu, R.M. | Deposit date: | 2018-10-25 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. Structure, 27, 2019
|
|
5C53
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-01-27 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.567 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4Q2E
| CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S258C, active mutant) | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, POTASSIUM ION, ... | Authors: | Liu, X, Yin, Y, Wu, J, Liu, Z. | Deposit date: | 2014-04-08 | Release date: | 2014-07-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis Nat Commun, 5, 2014
|
|
6IG4
| Structure of mitochondrial CDP-DAG synthase Tam41, delta 74 | Descriptor: | PLATINUM (II) ION, Phosphatidate cytidylyltransferase, mitochondrial, ... | Authors: | Jiao, H.Z, Yin, Y, Liu, Z.F. | Deposit date: | 2018-09-23 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.261 Å) | Cite: | Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site. Structure, 27, 2019
|
|
5EGO
| HOXB13-MEIS1 heterodimer bound to methylated DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-27 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
|
|
5EF6
| Structure of HOXB13 complex with methylated DNA | Descriptor: | DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13 | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-23 | Release date: | 2017-02-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
|
|
5EG0
| HOXB13-MEIS1 heterodimer bound to DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-26 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.101 Å) | Cite: | Molecular basis of recognition of two distinct DNA sequences by a single transcription factor To Be Published
|
|
5C52
| Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma | Descriptor: | DNA (26-MER), DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), DNA polymerase subunit gamma-1, ... | Authors: | Sohl, C.D, Szymanski, M.R, Mislak, A.C, Shumate, C.K, Amiralaei, S, Schinazi, R.F, Anderson, K.S, Yin, Y.W. | Deposit date: | 2015-06-19 | Release date: | 2016-05-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.637 Å) | Cite: | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase gamma. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4Q2G
| CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S223C, inactive mutant) | Descriptor: | MAGNESIUM ION, MERCURY (II) ION, Phosphatidate cytidylyltransferase, ... | Authors: | Liu, X, Yin, Y, Wu, J, Liu, Z. | Deposit date: | 2014-04-08 | Release date: | 2014-07-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis Nat Commun, 5, 2014
|
|
7VF5
| Human m6A-METTL associated complex (WTAP, VIRMA, and HAKAI) | Descriptor: | Pre-mRNA-splicing regulator WTAP, Protein virilizer homolog | Authors: | Su, S, Li, S, Deng, T, Gao, M, Yin, Y, Wu, B, Peng, C, Liu, J, Ma, J, Zhang, K. | Deposit date: | 2021-09-10 | Release date: | 2022-09-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of human m6A writer complexes. Cell Res., 32, 2022
|
|
7VF2
| Human m6A-METTL associated complex (WTAP, VIRMA, ZC3H13, and HAKAI) | Descriptor: | Pre-mRNA-splicing regulator WTAP, Protein virilizer homolog, Zinc finger CCCH domain-containing protein 13 | Authors: | Su, S, Li, S, Deng, T, Gao, M, Yin, Y, Wu, B, Peng, C, Liu, J, Ma, J, Zhang, K. | Deposit date: | 2021-09-10 | Release date: | 2022-09-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of human m6A writer complexes. Cell Res., 32, 2022
|
|