5YNO
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![BU of 5yno by Molmil](/molmil-images/mine/5yno) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH and m7GpppA | Descriptor: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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7E4B
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![BU of 7e4b by Molmil](/molmil-images/mine/7e4b) | Crystal structure of MIF bound to compound 5 | Descriptor: | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | Deposit date: | 2021-02-11 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.772 Å) | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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5YN6
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![BU of 5yn6 by Molmil](/molmil-images/mine/5yn6) | Crystal structure of MERS-CoV nsp10/nsp16 complex bound to SAM | Descriptor: | S-ADENOSYLMETHIONINE, ZINC ION, nsp10 protein, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.947 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNN
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![BU of 5ynn by Molmil](/molmil-images/mine/5ynn) | Crystal structure of MERS-CoV nsp16/nsp10complex bound to sinefungin and m7GpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, SINEFUNGIN, ZINC ION, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNI
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![BU of 5yni by Molmil](/molmil-images/mine/5yni) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, S-ADENOSYLMETHIONINE, ZINC ION, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YN5
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![BU of 5yn5 by Molmil](/molmil-images/mine/5yn5) | Crystal structure of MERS-CoV nsp10/nsp16 complex | Descriptor: | ZINC ION, nsp10 protein, nsp16 protein | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNF
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![BU of 5ynf by Molmil](/molmil-images/mine/5ynf) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to m7GpppA | Descriptor: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ZINC ION, nsp10 protein, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNP
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![BU of 5ynp by Molmil](/molmil-images/mine/5ynp) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA | Descriptor: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, ZINC ION, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-25 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNB
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![BU of 5ynb by Molmil](/molmil-images/mine/5ynb) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to Sinefungin | Descriptor: | SINEFUNGIN, ZINC ION, nsp10 protein, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNM
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![BU of 5ynm by Molmil](/molmil-images/mine/5ynm) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppA | Descriptor: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYLMETHIONINE, ZINC ION, ... | Authors: | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | Deposit date: | 2017-10-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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7E08
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![BU of 7e08 by Molmil](/molmil-images/mine/7e08) | |
7EY2
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![BU of 7ey2 by Molmil](/molmil-images/mine/7ey2) | |
7EY1
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![BU of 7ey1 by Molmil](/molmil-images/mine/7ey1) | Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-D-xylosidase/beta-D-glucosidase, ... | Authors: | Gong, W.M, Yang, L.Y. | Deposit date: | 2021-05-29 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose To Be Published
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7DYG
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![BU of 7dyg by Molmil](/molmil-images/mine/7dyg) | |
7DYQ
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![BU of 7dyq by Molmil](/molmil-images/mine/7dyq) | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile | Descriptor: | 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile, FE (III) ION, Lysine-specific demethylase 4D | Authors: | Wang, T, Yang, L. | Deposit date: | 2021-01-22 | Release date: | 2022-01-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile To Be Published
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7E01
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![BU of 7e01 by Molmil](/molmil-images/mine/7e01) | |
7DZZ
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![BU of 7dzz by Molmil](/molmil-images/mine/7dzz) | Trans-3/4-proline-hydroxylase H11-stateV | Descriptor: | OXYGEN ATOM, PROLINE, Phytanoyl-CoA dioxygenase, ... | Authors: | Gong, W.G, Yang, L.Y. | Deposit date: | 2021-01-26 | Release date: | 2022-02-02 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Trans-3/4-proline-hydroxylase H11-stateV To Be Published
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5HA9
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![BU of 5ha9 by Molmil](/molmil-images/mine/5ha9) | Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer | Descriptor: | Amitriptyline, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | Authors: | Fu, L, Peng, H, Zhang, L, Ouyang, L. | Deposit date: | 2015-12-30 | Release date: | 2016-03-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.01 Å) | Cite: | Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. Sci Rep, 6, 2016
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6J3L
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![BU of 6j3l by Molmil](/molmil-images/mine/6j3l) | Solution structure of the N-terminal extended protuberant domain of eukaryotic ribosomal stalk protein P0 | Descriptor: | 60S acidic ribosomal protein P0 | Authors: | Choi, K.H.A, Lee, K.M, Yang, L, Wing-Heng Yu, C, Banfield, D.K, Ito, K, Uchiumi, T, Wong, K.B. | Deposit date: | 2019-01-04 | Release date: | 2019-09-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Mutagenesis Studies Evince the Role of the Extended Protuberant Domain of Ribosomal Protein uL10 in Protein Translation. Biochemistry, 58, 2019
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1PJF
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![BU of 1pjf by Molmil](/molmil-images/mine/1pjf) | Solid State NMR structure of the Pf1 Major Coat Protein in Magnetically Aligned Bacteriophage | Descriptor: | COAT PROTEIN B | Authors: | Thiriot, D.S, Nevzorov, A.A, Zagyanskiy, L, Wu, C.H, Opella, S.J. | Deposit date: | 2003-06-02 | Release date: | 2004-08-10 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy. J.Mol.Biol., 341, 2004
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5YAW
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![BU of 5yaw by Molmil](/molmil-images/mine/5yaw) | |
5YAV
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![BU of 5yav by Molmil](/molmil-images/mine/5yav) | Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction | Descriptor: | 1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Bing, X, Yanlian, L, Danyan, C. | Deposit date: | 2017-09-01 | Release date: | 2018-09-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.989 Å) | Cite: | Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction To Be Published
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5YOU
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![BU of 5you by Molmil](/molmil-images/mine/5you) | Crystal structure of BRD4-BD1 bound with hjp64 | Descriptor: | (3~{R})-4-cyclopropyl-~{N},1,3-trimethyl-~{N}-(4-methylphenyl)-2-oxidanylidene-3~{H}-quinoxaline-6-carboxamide, Bromodomain-containing protein 4 | Authors: | Bing, X, Jianping, H, Yanlian, L, Danyan, C. | Deposit date: | 2017-10-31 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.503 Å) | Cite: | Crystal structure of BRD4-BD1 bound with hjp64 To Be Published
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6KF1
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![BU of 6kf1 by Molmil](/molmil-images/mine/6kf1) | Microbial Hormone-sensitive lipase- E53 mutant S162A | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HEXANOIC ACID, ... | Authors: | Xiaochen, Y, Zhengyang, L, Xuewei, X, Jixi, L. | Deposit date: | 2019-07-05 | Release date: | 2020-07-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | Functional and Structural Insights into Environmental Adaptation of a Novel Hormone-sensitive Lipase, E53, Obtained from Erythrobacter longus To Be Published
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7V99
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![BU of 7v99 by Molmil](/molmil-images/mine/7v99) | catalytic core of human telomerase holoenzyme | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | Authors: | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-24 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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