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PDB: 22 件
6AX4
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Plk-1 polo-box domain in complex with histidine N(tau)-cyclized Macrocycle 5b.
分子名称: AMYLAMINE, Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b
著者Grant, R.A, Hymel, D, Yaffe, M.B, Burke, T.R.
登録日2017-09-06
公開日2018-09-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
1YWT
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Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1)
著者Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B.
登録日2005-02-18
公開日2005-03-01
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
6QQN
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Tubulin-TH588 complex
分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Patterson, J.C, Joughin, B.A, Prota, A.E, Muehlethaler, T, Jonas, O.H, Whitman, M.A, Varmeh, S, Chen, S, Balk, S.P, Steinmetz, M.O, Lauffenburger, D.A, Yaffe, M.B.
登録日2019-02-18
公開日2019-07-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Cell Syst, 9, 2019
7MSO
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BU of 7mso by Molmil
Crystal Structure of Polo Box Domain in Complex with Cyclic Peptide Inhibitor
分子名称: Cyclic Peptide Inhibitor ZO1-GLN-SER-TPO-45W-MLL, Serine/threonine-protein kinase PLK1
著者Lim, D.C, Yaffe, M.B.
登録日2021-05-11
公開日2022-03-02
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.
J.Med.Chem., 65, 2022
7MX1
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PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog
分子名称: ACE-PRO-LEU-ALA-SER-TPO, N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide, Serine/threonine-protein kinase PLK1
著者Grant, R.A, Hymel, D, Yaffe, M.B, Burke, T.R.
登録日2021-05-17
公開日2022-03-30
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.
Org.Biomol.Chem., 19, 2021
1GXC
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FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide
分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE
著者Li, J, Williams, B.L, Haire, L.F, Goldberg, M, Wilker, E, Durocher, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J.
登録日2002-04-02
公開日2002-06-13
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
Mol.Cell, 9, 2002
3C5L
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Polo-like kinase 1 Polo box domain in complex with PPHSpT peptide
分子名称: Peptide, Serine/threonine-protein kinase PLK1
著者Lim, D.C, Yaffe, M.B.
登録日2008-01-31
公開日2009-02-17
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
1QJB
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
分子名称: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
著者Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
3FVH
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Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide
分子名称: Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide, Serine/threonine-protein kinase PLK1
著者Lim, D.C, Yaffe, M.B.
登録日2009-01-15
公開日2009-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Nat.Struct.Mol.Biol., 16, 2009
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
分子名称: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
著者Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1UMW
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Structure of a human Plk1 Polo-box domain/phosphopeptide complex
分子名称: PEPTIDE, SERINE/THREONINE-PROTEIN KINASE PLK
著者Rellos, P, Elia, A, Yaffe, M.B, Smerdon, S.J.
登録日2003-08-29
公開日2003-10-16
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
Cell(Cambridge,Mass.), 115, 2003
1T15
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Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
分子名称: BRCA1 interacting protein C-terminal helicase 1, Breast cancer type 1 susceptibility protein
著者Clapperton, J.A, Manke, I.A, Lowery, D.M, Ho, T, Haire, L.F, Yaffe, M.B, Smerdon, S.J.
登録日2004-04-15
公開日2004-05-11
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
2PIE
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Crystal structure of the FHA domain of RNF8 in complex with its optimal phosphopeptide
分子名称: E3 ubiquitin-protein ligase RNF8, phosphopeptide
著者Grant, R.A, Yaffe, M.B.
登録日2007-04-13
公開日2007-12-11
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.
Cell(Cambridge,Mass.), 131, 2007
2C1N
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BU of 2c1n by Molmil
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
分子名称: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
登録日2005-09-16
公開日2005-11-02
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2C1J
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Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
分子名称: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
登録日2005-09-15
公開日2005-11-02
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
分子名称: SAP SH2 DOMAIN, SULFATE ION
著者Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
登録日1999-09-22
公開日1999-10-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
分子名称: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP
著者Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
分子名称: SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE, T CELL SIGNAL TRANSDUCTION MOLECULE SAP
著者Poy, F, Yaffe, M.B, Sayos, J, Saxena, K, Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
2AZM
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Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
分子名称: GAMMA-H2AX HISTONE, Mediator of DNA damage checkpoint protein 1
著者Clapperton, J.A, Stucki, M, Mohammad, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J.
登録日2005-09-12
公開日2006-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
3RQ7
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Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor
分子名称: C6H5(CH2)8-derivatized peptide inhibitor, Serine/threonine-protein kinase PLK1
著者Liu, F, Park, J.-E, Qian, W.-J, Lim, D.C, Graber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
登録日2011-04-27
公開日2011-07-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
4DFW
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Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
分子名称: CHLORIDE ION, Peptide, Serine/threonine-protein kinase PLK1
著者Liu, F, Park, J.-E, Qian, W.-J, Lim, D, Gr ber, M, Berg, T, Yaffe, M.B, Lee, K.S, Burke Jr, T.R.
登録日2012-01-24
公開日2012-03-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
4O6W
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Peptide-Based Inhibitors of Plk1 Polo-box Domain
分子名称: Peptide-Based inhibitor, Serine/threonine-protein kinase PLK1
著者Qian, W.-J, Park, J.-E, Lim, D.C, Park, S.-Y, Lee, K.-W, Yaffe, M.B, Lee, K.S, Burke, T.R.
登録日2013-12-23
公開日2014-12-03
実験手法X-RAY DIFFRACTION (1.448 Å)
主引用文献Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014

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