6JBY
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![BU of 6jby by Molmil](/molmil-images/mine/6jby) | Crystal structure of endo-deglycosylated hydroxynitrile lyase isozyme 5 of Prunus communis | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Zheng, Y.C, Li, F.L, Yu, H.L, Xu, J.H. | Deposit date: | 2019-01-27 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes. Acs Catalysis, 2020
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5ZFM
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![BU of 5zfm by Molmil](/molmil-images/mine/5zfm) | Ketoreductase LbCR mutant - M6 | Descriptor: | 3-oxoacyl-acyl carrier protein reductase | Authors: | Gong, X.M, Zheng, G.W, Xu, J.H. | Deposit date: | 2018-03-06 | Release date: | 2019-01-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor Acs Catalysis, 9, 2019
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5ZI0
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![BU of 5zi0 by Molmil](/molmil-images/mine/5zi0) | Ketoreductase LbCR mutant - M8 | Descriptor: | 3-oxoacyl-acyl carrier protein reductase | Authors: | Gong, X.M, Zheng, G.W, Xu, J.H. | Deposit date: | 2018-03-14 | Release date: | 2019-01-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor Acs Catalysis, 9, 2019
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5YWL
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![BU of 5ywl by Molmil](/molmil-images/mine/5ywl) | SsCR_L211H | Descriptor: | Protein induced by osmotic stress | Authors: | Shang, Y.P, Chen, Q, Li, A.T, Yu, H.L, Xu, J.H. | Deposit date: | 2017-11-29 | Release date: | 2019-03-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol., 308, 2020
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5YWN
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![BU of 5ywn by Molmil](/molmil-images/mine/5ywn) | SsCR_L211H-NADP+ | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protein induced by osmotic stress | Authors: | Shang, Y.P, Chen, Q, Yu, H.L, Xu, J.H. | Deposit date: | 2017-11-29 | Release date: | 2019-03-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.039 Å) | Cite: | Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol., 308, 2020
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5YW4
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![BU of 5yw4 by Molmil](/molmil-images/mine/5yw4) | Structure-Guided Engineering of Reductase: Efficient Attenuating Substrate Inhibition in Asymmetric Catalysis | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protein induced by osmotic stress | Authors: | Shang, Y.P, Chen, Q, Li, A.T, Yu, H.L, Xu, J.H. | Deposit date: | 2017-11-28 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol., 308, 2020
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7XDU
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![BU of 7xdu by Molmil](/molmil-images/mine/7xdu) | TtherAmDH-NAD+ | Descriptor: | 4-hydroxy-tetrahydrodipicolinate reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Chen, C, Qian, Y.Y, Pan, J, Bai, Y.P, Xu, J.H. | Deposit date: | 2022-03-28 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Stereoselective synthesis of chiral lactams via an engineered natural amine dehydrogenase. To Be Published
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7XWU
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![BU of 7xwu by Molmil](/molmil-images/mine/7xwu) | Ketoreductase CpKR mutant - M1 | Descriptor: | DI(HYDROXYETHYL)ETHER, Epimerase domain-containing protein, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Chen, C, Zheng, Y.C, Pan, J, Xu, J.H. | Deposit date: | 2022-05-27 | Release date: | 2023-05-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Computational Redesign of a robust Ketoreductase for Asymmetric Synthesis of Enantiopure diltiazem precursor. To Be Published
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7Y0K
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![BU of 7y0k by Molmil](/molmil-images/mine/7y0k) | |
7CG2
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![BU of 7cg2 by Molmil](/molmil-images/mine/7cg2) | Vigna radiata Epoxide hydrolase mutant | Descriptor: | Epoxide hydrolase | Authors: | Li, F.L, Yu, H.L, Xu, J.H. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds Adv.Synth.Catal., 362, 2021
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7CG6
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![BU of 7cg6 by Molmil](/molmil-images/mine/7cg6) | Vigna radiata Epoxide hydrolase mutant M263Q | Descriptor: | Epoxide hydrolase | Authors: | Li, F.L, Yu, H.L, Xu, J.H. | Deposit date: | 2020-06-30 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds Adv.Synth.Catal., 362, 2021
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7DUS
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![BU of 7dus by Molmil](/molmil-images/mine/7dus) | |
5YQT
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![BU of 5yqt by Molmil](/molmil-images/mine/5yqt) | Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide | Descriptor: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase | Authors: | Kong, X.D, Sun, Z.T, Wu, L, Reetz, M.T, Zhou, J.H, Xu, J.H. | Deposit date: | 2017-11-07 | Release date: | 2018-06-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. J. Am. Chem. Soc., 140, 2018
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