5YW4

Structure-Guided Engineering of Reductase: Efficient Attenuating Substrate Inhibition in Asymmetric Catalysis

Summary for 5YW4

Entry DOI	10.2210/pdb5yw4/pdb
Descriptor	Protein induced by osmotic stress, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywords	reductase, nadp+, asymmetric catalysis, oxidoreductase
Biological source	Scheffersomyces stipitis (Yeast)
Total number of polymer chains	1
Total formula weight	37749.27
Authors	Shang, Y.P.,Chen, Q.,Li, A.T.,Yu, H.L.,Xu, J.H. (deposition date: 2017-11-28, release date: 2019-03-06, Last modification date: 2023-11-22)
Primary citation	Shang, Y.P.,Chen, Q.,Li, A.T.,Quan, S.,Xu, J.H.,Yu, H.L. Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol., 308:141-147, 2020 Cited by PubMed: 31866427 DOI: 10.1016/j.jbiotec.2019.12.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.047 Å)

Structure validation