4XFU
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![BU of 4xfu by Molmil](/molmil-images/mine/4xfu) | Structure of IL-18 SER Mutant V | Descriptor: | Interleukin-18 | Authors: | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | Deposit date: | 2014-12-29 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4XFT
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![BU of 4xft by Molmil](/molmil-images/mine/4xft) | Structure of IL-18 SER Mutant III | Descriptor: | DIMETHYL SULFOXIDE, Interleukin-18 | Authors: | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | Deposit date: | 2014-12-29 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4XFS
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![BU of 4xfs by Molmil](/molmil-images/mine/4xfs) | Structure of IL-18 SER Mutant I | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 | Authors: | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | Deposit date: | 2014-12-28 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
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4ZM6
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![BU of 4zm6 by Molmil](/molmil-images/mine/4zm6) | A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain GH3 beta-N-acetylglucosaminidase | Descriptor: | ACETYL COENZYME *A, N-acetyl-beta-D glucosaminidase, SULFATE ION | Authors: | Qin, Z, Xiao, Y, Yang, X, Jiang, Z, Yang, S, Mesters, J.R. | Deposit date: | 2015-05-02 | Release date: | 2015-12-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 beta-N-acetylglucosaminidase Sci Rep, 5, 2015
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5KIJ
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![BU of 5kij by Molmil](/molmil-images/mine/5kij) | Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex | Descriptor: | 1,4-BUTANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, ... | Authors: | Karaveg, K, Xiang, Y, Moremen, K.W. | Deposit date: | 2016-06-16 | Release date: | 2017-05-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.649 Å) | Cite: | Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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4EEE
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![BU of 4eee by Molmil](/molmil-images/mine/4eee) | |
4EKX
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![BU of 4ekx by Molmil](/molmil-images/mine/4ekx) | |
4F7K
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![BU of 4f7k by Molmil](/molmil-images/mine/4f7k) | |
3MUU
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![BU of 3muu by Molmil](/molmil-images/mine/3muu) | Crystal structure of the Sindbis virus E2-E1 heterodimer at low pH | Descriptor: | Structural polyprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, L, Jose, J, Xiang, Y, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2010-05-03 | Release date: | 2010-11-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structural changes of envelope proteins during alphavirus fusion. Nature, 468, 2010
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3MUW
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![BU of 3muw by Molmil](/molmil-images/mine/3muw) | Pseudo-atomic structure of the E2-E1 protein shell in Sindbis virus | Descriptor: | Structural polyprotein | Authors: | Li, L, Jose, J, Xiang, Y, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2010-05-03 | Release date: | 2010-11-24 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural changes of envelope proteins during alphavirus fusion. Nature, 468, 2010
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3O5Z
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![BU of 3o5z by Molmil](/molmil-images/mine/3o5z) | Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Phosphatidylinositol 3-kinase regulatory subunit beta | Authors: | Chen, S, Xiao, Y, Ponnusamy, R, Tan, J, Lei, J, Hilgenfeld, R. | Deposit date: | 2010-07-28 | Release date: | 2011-08-10 | Last modified: | 2014-09-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit Acta Crystallogr.,Sect.F, 67, 2011
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7K39
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![BU of 7k39 by Molmil](/molmil-images/mine/7k39) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K3A
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![BU of 7k3a by Molmil](/molmil-images/mine/7k3a) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K3B
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![BU of 7k3b by Molmil](/molmil-images/mine/7k3b) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K37
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![BU of 7k37 by Molmil](/molmil-images/mine/7k37) | Structure of full-length influenza HA with a head-binding antibody at pH 7.8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Xiang, Y, Gao, J. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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8JY0
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![BU of 8jy0 by Molmil](/molmil-images/mine/8jy0) | Crystal structure of RhoBAST complexed with TMR-DN | Descriptor: | 2,4-dinitroaniline, 5-aminocarbonyl-2-[3-(dimethylamino)-6-dimethylazaniumylidene-xanthen-9-yl]benzoate, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Zhang, Y, Xiao, Y, Xu, Z, Fang, X. | Deposit date: | 2023-07-02 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nat Commun, 15, 2024
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4JNM
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![BU of 4jnm by Molmil](/molmil-images/mine/4jnm) | Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties | Descriptor: | 1,2-ETHANEDIOL, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, Nicotinamide phosphoribosyltransferase, ... | Authors: | Gunzner-Toste, J, Zhao, G, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Fu, B, Han, B, Ho, Y, Kley, N, Liederer, B, Lin, J, Mukadam, S, O'Brien, T, Reynolds, D.J, Sharma, G, Skelton, N, Smith, C.C, Oh, A, Wang, W, Wang, Z, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X, Bair, K.W, Dragovich, P.S. | Deposit date: | 2013-03-15 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg.Med.Chem.Lett., 23, 2013
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6A7F
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![BU of 6a7f by Molmil](/molmil-images/mine/6a7f) | |
8I3V
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![BU of 8i3v by Molmil](/molmil-images/mine/8i3v) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2023-01-18 | Release date: | 2024-07-03 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024
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8IXZ
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8IY1
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![BU of 8iy1 by Molmil](/molmil-images/mine/8iy1) | Structure of Acb2 complexed with cAAG | Descriptor: | GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, p26 | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8IY0
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![BU of 8iy0 by Molmil](/molmil-images/mine/8iy0) | Structure of Acb2 complexed with cAAA | Descriptor: | [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, p26 | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8IY2
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![BU of 8iy2 by Molmil](/molmil-images/mine/8iy2) | Structure of Acb2 complexed with 3',3'-cGAMP and cAAA | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ... | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8J8O
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![BU of 8j8o by Molmil](/molmil-images/mine/8j8o) | Structure of Acb2 complexed with 2',3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, cGAMP, ... | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-05-02 | Release date: | 2024-02-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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5YJ7
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![BU of 5yj7 by Molmil](/molmil-images/mine/5yj7) | Structural insight into the beta-GH1 glucosidase BGLN1 from oleaginous microalgae Nannochloropsis | Descriptor: | CALCIUM ION, GLYCEROL, Glycoside hydrolase | Authors: | Dong, S, Liu, Y.J, Zhou, H.X, Xiao, Y, Xu, J, Cui, Q, Wang, X.Q, Feng, Y.G. | Deposit date: | 2017-10-09 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structural insight into a GH1 beta-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int.J.Biol.Macromol., 170, 2021
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