5KIJ

Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex

Summary for 5KIJ

• Entry DOI: 10.2210/pdb5kij/pdb
• Descriptor: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LANTHANUM (III) ION, ... (7 entities in total)
• Functional Keywords: alpha/alpha-barrel, cation replacement, protein-glycan interaction, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 54441.18

Authors

Karaveg, K.,Xiang, Y.,Moremen, K.W. (deposition date: 2016-06-16, release date: 2017-05-10, Last modification date: 2023-09-27)

• Primary citation: Xiang, Y.,Karaveg, K.,Moremen, K.W.; Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.; Proc. Natl. Acad. Sci. U.S.A., 113:E7890-E7899, 2016; PubMed: 27856750; DOI: 10.1073/pnas.1611213113

Experimental method

X-RAY DIFFRACTION (1.649 Å)