5KIJ

Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004571	molecular_function	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
A	0005509	molecular_function	calcium ion binding
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305

Chain	Residue	Details
A	GLU330

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000305

Chain	Residue	Details
A	ASP463
A	GLU599

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P31723

Chain	Residue	Details
A	GLU570

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P32906

Chain	Residue	Details
A	THR688

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 19

Chain	Residue	Details
A	GLU330	steric role
A	ARG334	steric role
A	ASP463	electrostatic stabiliser, proton acceptor, proton donor
A	GLU599	increase nucleophilicity, proton acceptor, proton donor

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