3GW5
 
 | | Crystal structure of human renin complexed with a novel inhibitor | | 分子名称: | (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, Z, McKeever, B.M. | | 登録日 | 2009-03-31 | | 公開日 | 2009-06-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Bioorg.Med.Chem.Lett., 19, 2009
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1NAJ
 | | High resolution NMR Structure Of DNA Dodecamer Determined In Aqueous Dilute Liquid Crystalline Phase | | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3' | | 著者 | Wu, Z, Delaglio, F, Tjandra, N, Zhurkin, V, Bax, A. | | 登録日 | 2002-11-27 | | 公開日 | 2003-07-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and (31)P chemical shift anisotropy.
J.Biomol.Nmr, 26, 2003
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3Q3T
 | | Alkyl Amine Renin Inhibitors: Filling S1 from S3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Wu, Z, McKeever, B. | | 登録日 | 2010-12-22 | | 公開日 | 2011-08-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket.
Bioorg.Med.Chem.Lett., 21, 2011
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3Q4B
 | | Clinically Useful Alkyl Amine Renin Inhibitors | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Renin, ... | | 著者 | Wu, Z, McKeever, B.M. | | 登録日 | 2010-12-23 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
ACS Med Chem Lett, 2, 2011
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3KM4
 | | Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors | | 分子名称: | (3R)-3-[(1S)-4-(acetylamino)-1-(3-chlorophenyl)-1-hydroxybutyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, Z, McKeever, B.M. | | 登録日 | 2009-11-09 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Optimization of orally bioavailable alkyl amine renin inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
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3Q5H
 | | Clinically Useful Alkyl Amine Renin Inhibitors | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Renin, ... | | 著者 | Wu, Z, McKeever, B.M. | | 登録日 | 2010-12-28 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
ACS Med Chem Lett, 2, 2011
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1ZWO
 | | NMR structure of murine gamma-S crystallin | | 分子名称: | Gamma crystallin S | | 著者 | Wu, Z, Delaglio, F, Wyatt, K, Wistow, G, Bax, A. | | 登録日 | 2005-06-04 | | 公開日 | 2005-07-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR.
Protein Sci., 14, 2005
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1ZWM
 | | NMR structure of murine gamma-S crystallin | | 分子名称: | Gamma crystallin S | | 著者 | Wu, Z, Delaglio, F, Wyatt, K, Wistow, G, Bax, A. | | 登録日 | 2005-06-03 | | 公開日 | 2005-07-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR.
Protein Sci., 14, 2005
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3K2S
 | | Solution structure of double super helix model | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Apolipoprotein A-I, CHOLESTEROL | | 著者 | Wu, Z, Gogonea, V, Lee, X, Wagner, M.A, Li, X.-M, Huang, Y, Undurti, A, May, R.P, Haertlein, M, Moulin, M, Gutsche, I, Zaccai, G, Didonato, J.A, Hazen, L.S. | | 登録日 | 2009-09-30 | | 公開日 | 2010-04-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | SOLUTION SCATTERING | | 主引用文献 | Double superhelix model of high density lipoprotein.
J.Biol.Chem., 284, 2009
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2NRF
 | | Crystal Structure of GlpG, a Rhomboid family intramembrane protease | | 分子名称: | Protein GlpG | | 著者 | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | | 登録日 | 2006-11-02 | | 公開日 | 2006-11-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.
Nat.Struct.Mol.Biol., 13, 2006
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7XOE
 | | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | | 登録日 | 2022-05-01 | | 公開日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
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7XOG
 | | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | | 登録日 | 2022-05-01 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
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7WJU
 | | Cryo-EM structure of the AsCas12f1-sgRNAv1-dsDNA ternary complex | | 分子名称: | Non-target strand, OrfB_Zn_ribbon domain-containing protein, Target strand, ... | | 著者 | Wu, Z, Liu, D, Shen, H, Ji, Q. | | 登録日 | 2022-01-07 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structure-directed functional evolution of the miniature CRISPR-AsCas12f1 system
To Be Published
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5VTO
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6LBU
 | | Crystal structure of yeast Stn1 and Ten1 | | 分子名称: | KLLA0C11825p, KLLA0E09417p | | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2019-11-14 | | 公開日 | 2020-07-15 | | 最終更新日 | 2020-08-19 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
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6LTH
 | | Structure of human BAF Base module | | 分子名称: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | | 登録日 | 2020-01-22 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
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6LTJ
 | | Structure of nucleosome-bound human BAF complex | | 分子名称: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | | 登録日 | 2020-01-22 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
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3B4R
 | | Site-2 Protease from Methanocaldococcus jannaschii | | 分子名称: | Putative zinc metalloprotease MJ0392, ZINC ION | | 著者 | Jeffrey, P.D, Feng, L, Yan, H, Wu, Z, Yan, N, Wang, Z, Shi, Y. | | 登録日 | 2007-10-24 | | 公開日 | 2008-01-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of a site-2 protease family intramembrane metalloprotease.
Science, 318, 2007
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1YOP
 | | The solution structure of Kti11p | | 分子名称: | Kti11p, ZINC ION | | 著者 | Sun, J, Zhang, J, Wu, F, Xu, C, Li, S, Zhao, W, Wu, Z, Wu, J, Zhou, C.-Z, Shi, Y. | | 登録日 | 2005-01-28 | | 公開日 | 2005-04-05 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module.
Biochemistry, 44, 2005
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8IOY
 | | Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP | | 分子名称: | Copper-transporting ATPase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Yang, G, Xu, L, Guo, J, Wu, Z. | | 登録日 | 2023-03-13 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
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1QBQ
 | | STRUCTURE OF RAT FARNESYL PROTEIN TRANSFERASE COMPLEXED WITH A CVIM PEPTIDE AND ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID. | | 分子名称: | ACETATE ION, ACETYL-CYS-VAL-ILE-SELENOMET-COOH PEPTIDE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, ... | | 著者 | Strickland, C.L, Windsor, W.T, Syto, R, Wang, L, Bond, R, Wu, Z, Schwartz, J, Le, H.V, Beese, L.S, Weber, P.C. | | 登録日 | 1999-04-27 | | 公開日 | 1999-06-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue
Biochemistry, 37, 1998
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6M0W
 | | Crystal structure of Streptococcus thermophilus Cas9 in complex with the AGAA PAM | | 分子名称: | CRISPR-associated endonuclease Cas9 1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*GP*AP*AP*GP*C)-3'), ... | | 著者 | Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q. | | 登録日 | 2020-02-23 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Nat Catal, 2020
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7V2Y
 | | cryo-EM structure of yeast THO complex with Sub2 | | 分子名称: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-10 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
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7V2W
 | | protomer structure from the dimer of yeast THO complex | | 分子名称: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-10 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
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1ZXT
 | | Crystal Structure of A Viral Chemokine | | 分子名称: | functional macrophage inflammatory protein 1-alpha homolog | | 著者 | Luz, J.G, Yu, M, Su, Y, Wu, Z, Zhou, Z, Sun, R, Wilson, I.A. | | 登録日 | 2005-06-08 | | 公開日 | 2005-08-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
J.Mol.Biol., 352, 2005
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