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PDB: 314 件
4URV
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BU of 4urv by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 4-(4-BROMOPHENYL)PIPERIDIN-4-OL, FORMIC ACID, GTPASE HRAS, ...
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US1
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BU of 4us1 by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: (3S)-3-[3-(aminomethyl)phenyl]-1-ethylpyrrolidine-2,5-dione, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URW
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The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URY
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BU of 4ury by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: GTPASE HRAS, N-[(4-aminophenyl)sulfonyl]cyclopropanecarboxamide, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US2
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BU of 4us2 by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 3-[(3R)-1-ethyl-2,5-dioxopyrrolidin-3-yl]benzamide, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US0
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BU of 4us0 by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 1-ETHYL-PYRROLIDINE-2,5-DIONE, GTPase HRas, Son of sevenless homolog 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URZ
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BU of 4urz by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 1-[(4-aminophenyl)sulfonyl]piperidin-2-one, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URX
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BU of 4urx by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 1-(4-bromobenzyl)pyrrolidine, 6-bromo-1H-indole, FORMIC ACID, ...
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URU
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BU of 4uru by Molmil
The crystal structure of H-Ras and SOS in complex with ligands
分子名称: 4-METHOXY-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1
著者Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G.
登録日2014-07-02
公開日2015-03-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
1HCO
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BU of 1hco by Molmil
THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
分子名称: CARBON MONOXIDE, HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN), HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN), ...
著者Baldwin, J.M.
登録日1979-08-07
公開日1979-08-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structure of human carbonmonoxy haemoglobin at 2.7 A resolution.
J.Mol.Biol., 136, 1980
3IFV
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BU of 3ifv by Molmil
Crystal structure of the Haloferax volcanii proliferating cell nuclear antigen
分子名称: PCNA, SODIUM ION
著者Winter, J.A, Christofi, P, Morroll, S, Bunting, K.A.
登録日2009-07-26
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation
Bmc Struct.Biol., 9, 2009
4RO5
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BU of 4ro5 by Molmil
Crystal structure of the SAT domain from the non-reducing fungal polyketide synthase CazM
分子名称: GLYCEROL, SAT domain from CazM
著者Winter, J.M, Cascio, D, Sawaya, M.R, Tang, Y.
登録日2014-10-27
公開日2015-09-09
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.
J.Am.Chem.Soc., 137, 2015
4RPM
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BU of 4rpm by Molmil
Crystal structure of the SAT domain from the non-reducing fungal polyketide synthase CazM with bound hexanoyl
分子名称: HEXANOIC ACID, HEXANOYL-COENZYME A, SAT domain from CazM
著者Winter, J.M, Cascio, D, Sawaya, M.R, Tang, Y.
登録日2014-10-30
公開日2015-09-09
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.
J.Am.Chem.Soc., 137, 2015
4P3F
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BU of 4p3f by Molmil
Structure of the human SRP68-RBD
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Signal recognition particle subunit SRP68
著者Grotwinkel, J.T, Wild, K, Sinning, I.
登録日2014-03-07
公開日2014-04-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献SRP RNA remodeling by SRP68 explains its role in protein translocation.
Science, 344, 2014
4P3G
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BU of 4p3g by Molmil
Structure of the SRP68-RBD from Chaetomium thermophilum
分子名称: PHOSPHATE ION, Signal recognition particle subunit SRP68
著者Grotwinkel, J.T, Wild, K, Sinning, I.
登録日2014-03-07
公開日2014-04-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献SRP RNA remodeling by SRP68 explains its role in protein translocation.
Science, 344, 2014
3ET6
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BU of 3et6 by Molmil
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
分子名称: PHOSPHATE ION, Soluble guanylyl cyclase beta
著者Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J.
登録日2008-10-07
公開日2008-10-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.
Bmc Struct.Biol., 8, 2008
3FW1
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BU of 3fw1 by Molmil
Quinone Reductase 2
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Winger, J.A, Hantschel, O, Superti-Furga, G, Kuriyan, J.
登録日2009-01-16
公開日2009-03-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Bmc Struct.Biol., 9, 2009
4P3E
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BU of 4p3e by Molmil
Structure of the human SRP S domain
分子名称: MAGNESIUM ION, SRP RNA (124-mer), Signal recognition particle 19 kDa protein, ...
著者Grotwinkel, J.T, Wild, K, Sinning, I.
登録日2014-03-07
公開日2014-04-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献SRP RNA remodeling by SRP68 explains its role in protein translocation.
Science, 344, 2014
2HCO
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BU of 2hco by Molmil
THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
分子名称: CARBON MONOXIDE, HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN), HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN), ...
著者Baldwin, J.M.
登録日1979-08-07
公開日1979-08-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structure of human carbonmonoxy haemoglobin at 2.7 A resolution.
J.Mol.Biol., 136, 1980
2H15
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BU of 2h15 by Molmil
Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II
分子名称: Carbonic anhydrase 2, MERCURY (II) ION, N-{[(3AS,5AR,8AR,8BS)-2,2,7,7-TETRAMETHYLTETRAHYDRO-3AH-BIS[1,3]DIOXOLO[4,5-B:4',5'-D]PYRAN-3A-YL]METHYL}SULFAMIDE, ...
著者Winum, J.Y, Temperini, C, Ciattini, S, Scozzafava, A, Supuran, C.T.
登録日2006-05-16
公開日2007-03-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
J.Med.Chem., 49, 2006
2LQT
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BU of 2lqt by Molmil
Solution structure of CHCHD7
分子名称: Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
著者Winkelmann, J, Ciofi-Baffoni, S, Banci, L, Bertini, I.
登録日2012-03-14
公開日2012-10-24
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural characterization of CHCHD5 and CHCHD7: Two atypical human twin CX(9)C proteins.
J.Struct.Biol., 180, 2012
3ZRG
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BU of 3zrg by Molmil
Crystal structure of RxLR effector PexRD2 from Phytophthora infestans
分子名称: BROMIDE ION, PEXRD2 FAMILY SECRETED RXLR EFFECTOR PEPTIDE, PUTATIVE
著者King, S.R.F, Boutemy, L.S, Win, J, Hughes, R.K, Clarke, T.A, Blumenschein, T.M.A, Kamoun, S, Banfield, M.J.
登録日2011-06-16
公開日2011-08-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of Phytophthora Rxlr Effector Proteins: A Conserved But Adaptable Fold Underpins Functional Diversity.
J.Biol.Chem., 286, 2011
3ZR8
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BU of 3zr8 by Molmil
Crystal structure of RxLR effector Avr3a11 from Phytophthora capsici
分子名称: AVR3A11, CHLORIDE ION, TRIETHYLENE GLYCOL
著者Boutemy, L.S, King, S.R.F, Win, J, Hughes, R.K, Clarke, T.A, Blumenschein, T.M.A, Kamoun, S, Banfield, M.J.
登録日2011-06-15
公開日2011-08-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Structures of Phytophthora Rxlr Effector Proteins: A Conserved But Adaptable Fold Underpins Functional Diversity.
J.Biol.Chem., 286, 2011
5VGM
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BU of 5vgm by Molmil
Crystal structure of dihydroorotase pyrC from Vibrio cholerae in complex with zinc at 1.95 A resolution.
分子名称: ACETATE ION, CHLORIDE ION, Dihydroorotase, ...
著者Lipowska, J, Shabalin, I.G, Miks, C.D, Winsor, J, Cooper, D.R, Shuvalova, L, Kwon, K, Lewinski, K, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2017-04-11
公開日2017-04-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae.
Int.J.Biol.Macromol., 136, 2019
1W3B
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BU of 1w3b by Molmil
The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
分子名称: CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110
著者Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E.
登録日2004-07-14
公開日2004-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004

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