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PDB: 888 件
5E99
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Bovine Fab fragment F08_B11
分子名称: Fab F08_B11 heavy chain, Fab F08_B11 light chain
著者Stanfield, R.L, Wilson, I.A.
登録日2015-10-14
公開日2016-08-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.
Sci Immunol, 1, 2016
6E7G
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Crystal structure of H5 hemagglutinin mutant Y161A from A/Viet Nam/1203/2004 H5N1 influenza virus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Tzarum, N, Wilson, I.A.
登録日2018-07-26
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.094 Å)
主引用文献N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
5FEH
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Crystal structure of PCT64_35B, a broadly neutralizing anti-HIV antibody
分子名称: 1,2-ETHANEDIOL, PCT64_26 Fab heavy chain, PCT64_26 Fab light chain, ...
著者Murrell, S, Wilson, I.A.
登録日2015-12-17
公開日2017-08-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage.
Immunity, 47, 2017
6E7H
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Crystal structure of H5 hemagglutinin mutant Y161A from A/Viet Nam/1203/2004 H5N1 influenza virus in complex with 3'-GcLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Tzarum, N, Wilson, I.A.
登録日2018-07-26
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
5E2Z
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Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ...
著者Zhu, X, Wilson, I.A.
登録日2015-10-01
公開日2015-12-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.624 Å)
主引用文献Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.
Cell Rep, 13, 2015
5E30
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Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ...
著者Zhu, X, Wilson, I.A.
登録日2015-10-01
公開日2015-12-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.
Cell Rep, 13, 2015
5E34
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Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1) with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zhu, X, Wilson, I.A.
登録日2015-10-01
公開日2015-12-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.
Cell Rep, 13, 2015
7T7B
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Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing antibody ADI-62113 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-62113 Fab heavy chain, ADI-62113 Fab light chain, ...
著者Liu, H, Wilson, I.A.
登録日2021-12-14
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron.
Commun Biol, 5, 2022
7TP3
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K288.2
分子名称: CACODYLATE ION, K288.2 heavy chain, K288.2 light chain, ...
著者Yuan, M, Zhu, X, Wilson, I.A.
登録日2022-01-24
公開日2022-02-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Sci Transl Med, 14, 2022
7TP4
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Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, K398.22 heavy chain, ...
著者Yuan, M, Zhu, X, Wilson, I.A.
登録日2022-01-24
公開日2022-02-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
Sci Transl Med, 14, 2022
7U5G
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ACS122 Fab
分子名称: ACS122 Fab Heavy chain, ACS122 Fab Light chain
著者Farokhi, E, Stanfield, R.L, Wilson, I.A.
登録日2022-03-02
公開日2022-11-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
Plos Pathog., 18, 2022
7TI6
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Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type)
著者Omorodion, O, Wilson, I.A.
登録日2022-01-12
公開日2022-10-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Immunity, 55, 2022
7U8L
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Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibody 31.a.83
分子名称: Antibody Fab light chain, Hemagglutinin HA1 subunit, Hemagglutinin HA2 subunit, ...
著者Zhu, X, Wilson, I.A.
登録日2022-03-08
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.56 Å)
主引用文献Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U8M
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Crystal structure of chimeric hemagglutinin cH15/3 in complex with broad protective antibodies 31.a.83 and FluA-20
分子名称: Antibody 31.a.83 Fab light chain, antibody 31.a.83 Fab heavy chain, antibody FluA-20 Fab heavy chain, ...
著者Zhu, X, Wilson, I.A.
登録日2022-03-08
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (5.39 Å)
主引用文献Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U8J
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Crystal structure of chimeric hemagglutinin cH4/3 in complex with broad protective antibody 31.a.83
分子名称: Antibody Fab light chain, Hemagglutinin HA1 subunit, Hemagglutinin HA2 subunit, ...
著者Zhu, X, Wilson, I.A.
登録日2022-03-08
公開日2022-06-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.9 Å)
主引用文献Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U0K
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BU of 7u0k by Molmil
IOMA class antibody Fab ACS124
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, IOMA Class antibody ACS124 Heavy chain, IOMA Class antibody ACS124 Light chain
著者Farokhi, E, Stanfield, R.L, Wilson, I.A.
登録日2022-02-18
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
Nat Commun, 13, 2022
7U04
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IOMA class antibody ACS101
分子名称: GLYCEROL, IOMA class antibody ACS101 heavy chain, IOMA class antibody ACS101 light chain
著者Farokhi, E, Stanfield, R.L, Wilson, I.A.
登録日2022-02-17
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
Nat Commun, 13, 2022
6N5A
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BU of 6n5a by Molmil
Crystal structure of an equine H7 hemagglutinin from A/equine/NY/49/73 (H7N7)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
著者Zhu, X, Wilson, I.A.
登録日2018-11-21
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.
Cell Rep, 27, 2019
5KUX
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BU of 5kux by Molmil
Designed influenza hemagglutinin binding protein HSB.2
分子名称: Designed influenza inhibitor protein HSB.2
著者Lee, P.S, Bernard, S.M, Wilson, I.A.
登録日2016-07-13
公開日2017-06-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
5KUY
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Influenza hemagglutinin H3 A/Hong Kong/1/1968 in complex with designed inhibitor protein HSB.2A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Designed influenza inhibitor HSB.2A, ...
著者Bernard, S.M, Wilson, I.A.
登録日2016-07-13
公開日2017-06-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.598 Å)
主引用文献Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
6FYT
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Structure of H1 (A/solomon Islands/3/06) Influenza Hemagglutinin in complex with SD38
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYS
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Structure of single domain antibody SD83
分子名称: 1,2-ETHANEDIOL, Single domain antibody SD83
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2022-03-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYW
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Structure of B/Brisbane/60/2008 Influenza Hemagglutinin in complex with SD83
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYU
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Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.643 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
4RNR
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BU of 4rnr by Molmil
Crystal structure of broadly neutralizing anti-HIV antibody PGT130
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PGT130 Heavy Chain, PGT130 Light Chain
著者Kong, L, Wilson, I.A.
登録日2014-10-24
公開日2014-11-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.758 Å)
主引用文献Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope.
J.Virol., 89, 2015

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