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PDB: 88 件
2DUT
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BU of 2dut by Molmil
Crystal structure of a M-loop deletion variant of MENT in the native conformation
分子名称: Heterochromatin-associated protein MENT
著者Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
登録日2006-07-26
公開日2006-08-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Embo J., 25, 2006
2H4Q
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BU of 2h4q by Molmil
Crystal structure of a M-loop deletion variant of MENT in the cleaved conformation
分子名称: Heterochromatin-associated protein MENT
著者Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
登録日2006-05-25
公開日2006-07-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
4V3N
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BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
分子名称: PLEUROTOLYSIN A, PLEUROTOLYSIN B
著者Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
登録日2014-10-20
公開日2015-02-18
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (14 Å)
主引用文献Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
分子名称: PLEUROTOLYSIN A, PLEUROTOLYSIN B
著者Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
登録日2014-10-15
公開日2015-02-18
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (11 Å)
主引用文献Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
3ZLG
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BU of 3zlg by Molmil
Structure of group A Streptococcal enolase K362A mutant
分子名称: ENOLASE, PHOSPHATE ION
著者Cork, A.J, Ericsson, D.J, Law, R.H.P, Casey, L.W, Valkov, E, Bertozzi, C, Stamp, A, Aquilina, J.A, Whisstock, J.C, Walker, M.J, Kobe, B.
登録日2013-01-31
公開日2014-02-05
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
3ZLH
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BU of 3zlh by Molmil
Structure of group A Streptococcal enolase
分子名称: ENOLASE
著者Cork, A.J, Ericsson, D.J, Law, R.H.P, Casey, L.W, Valkov, E, Bertozzi, C, Stamp, A, Aquilina, J.A, Whisstock, J.C, Walker, M.J, Kobe, B.
登録日2013-01-31
公開日2014-02-05
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
4WVM
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BU of 4wvm by Molmil
Stonustoxin structure
分子名称: Stonustoxin subunit alpha, Stonustoxin subunit beta
著者Ellisdon, A.M, Panjikar, S, Whisstock, J.C, McGowan, S.
登録日2014-11-06
公開日2015-12-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4Y1S
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BU of 4y1s by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
分子名称: CALCIUM ION, Perforin-1
著者Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
登録日2015-02-09
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.611 Å)
主引用文献Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
4Y1T
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Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
分子名称: CALCIUM ION, Perforin-1
著者Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
登録日2015-02-09
公開日2015-09-02
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.666 Å)
主引用文献Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
7UAB
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BU of 7uab by Molmil
Human pro-meprin alpha (zymogen state)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
登録日2022-03-12
公開日2022-11-02
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAI
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BU of 7uai by Molmil
Meprin alpha helix in complex with fetuin-B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
登録日2022-03-13
公開日2022-11-02
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAC
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BU of 7uac by Molmil
Human pro-meprin alpha (zymogen state)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Meprin A subunit alpha, ...
著者Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
登録日2022-03-12
公開日2022-11-02
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAF
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BU of 7uaf by Molmil
Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
登録日2022-03-12
公開日2022-11-02
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAE
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BU of 7uae by Molmil
Human meprin alpha (active state)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
登録日2022-03-12
公開日2022-11-02
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
5HN1
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BU of 5hn1 by Molmil
Crystal structure of Interleukin-37
分子名称: Interleukin-37, SULFATE ION
著者Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C.
登録日2016-01-17
公開日2017-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
4YON
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BU of 4yon by Molmil
P-Rex1:Rac1 complex
分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
著者Lucato, C.M, Whisstock, J.C, Ellisdon, A.M.
登録日2015-03-11
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015
4V3A
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BU of 4v3a by Molmil
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
分子名称: PLEUROTOLYSIN A, PLEUROTOLYSIN B
著者Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
登録日2014-10-17
公開日2015-02-18
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (15 Å)
主引用文献Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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BU of 4v3m by Molmil
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
分子名称: PLEUROTOLYSIN A, PLEUROTOLYSIN B
著者Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
登録日2014-10-20
公開日2015-02-18
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
1SNG
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BU of 1sng by Molmil
Structure of a Thermophilic Serpin in the Native State
分子名称: COG4826: Serine protease inhibitor, SULFATE ION
著者Fulton, K.F, Buckle, A.M, Cabrita, L.D, Irving, J.A, Butcher, R.E, Smith, I, Reeve, S, Lesk, A.M, Bottomley, S.P, Rossjohn, J, Whisstock, J.C.
登録日2004-03-10
公開日2004-12-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
J.Biol.Chem., 280, 2005
4DUR
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BU of 4dur by Molmil
The X-ray Crystal Structure of Full-Length type II Human Plasminogen
分子名称: ACETATE ION, BICARBONATE ION, CHLORIDE ION, ...
著者Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C.
登録日2012-02-22
公開日2012-03-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
4DUU
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BU of 4duu by Molmil
The X-ray Crystal Structure of Full-Length type I Human Plasminogen
分子名称: Plasminogen
著者Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C.
登録日2012-02-22
公開日2012-03-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (5.2 Å)
主引用文献The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
2IY9
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BU of 2iy9 by Molmil
Crystal structure of the A-subunit of the AB5 toxin from E. coli
分子名称: SUBA
著者Paton, A.W, Beddoe, T, Thorpe, C.M, Whisstock, J.C, Wilce, M.C.J, Rossjohn, J, Talbot, U.M, Paton, J.C.
登録日2006-07-13
公開日2006-10-04
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ab5 Subtilase Cytotoxin Inactivates the Endoplasmic Reticulum Chaperone Bip
Nature, 443, 2006
1D5S
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BU of 1d5s by Molmil
CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
分子名称: P1-ARG ANTITRYPSIN
著者Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P.
登録日1999-10-11
公開日2000-04-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
2QP2
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BU of 2qp2 by Molmil
Structure of a MACPF/perforin-like protein
分子名称: CALCIUM ION, Unknown protein
著者Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C.
登録日2007-07-22
公開日2007-09-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
2R9Y
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BU of 2r9y by Molmil
Structure of antiplasmin
分子名称: Alpha-2-antiplasmin
著者Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B.
登録日2007-09-14
公開日2007-12-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin
Blood, 111, 2008

 

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