4RIL
| Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | 分子名称: | Alpha-synuclein | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | 登録日 | 2014-10-06 | 公開日 | 2015-08-26 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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4YAY
| XFEL structure of human Angiotensin Receptor | 分子名称: | 5,7-diethyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-3,4-dihydro-1,6-naphthyridin-2(1H)-one, Soluble cytochrome b562,Type-1 angiotensin II receptor | 著者 | Zhang, H, Unal, H, Gati, C, Han, G.W, Zatsepin, N.A, James, D, Wang, D, Nelson, G, Weierstall, U, Messerschmidt, M, Williams, G.J, Boutet, S, Yefanov, O.M, White, T.A, Liu, W, Ishchenko, A, Tirupula, K.C, Desnoyer, R, Sawaya, M.C, Xu, Q, Coe, J, Cornrad, C.E, Fromme, P, Stevens, R.C, Katritch, V, Karnik, S.S, Cherezov, V, GPCR Network (GPCR) | 登録日 | 2015-02-18 | 公開日 | 2015-04-22 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell, 161, 2015
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6WQK
| hnRNPA2 Low complexity domain (LCD) determined by cryoEM | 分子名称: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | 著者 | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | 登録日 | 2020-04-29 | 公開日 | 2020-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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6WPQ
| GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | 分子名称: | Heterogeneous nuclear ribonucleoprotein A2 | 著者 | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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7UPE
| Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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7UPF
| Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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1Z9W
| Tetrameric structure of apo-7,8-Dihydroneopterin Aldolase from Mycobacterium tuberculosis | 分子名称: | Dihydroneopterin aldolase | 著者 | Goulding, C.W, Apostol, M.I, Sawaya, M.R, Philips, M, Parseghian, A, Eisenberg, D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | 登録日 | 2005-04-05 | 公開日 | 2005-04-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J.Mol.Biol., 349, 2005
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6ODG
| SVQIVY, Crystal Structure of a tau protein fragment | 分子名称: | Microtubule-associated protein tau | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | 登録日 | 2019-03-26 | 公開日 | 2019-10-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J.Biol.Chem., 294, 2019
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9ICW
| DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; NATIVE STRUCTURE | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... | 著者 | Pelletier, H, Sawaya, M.R. | 登録日 | 1995-12-16 | 公開日 | 1996-11-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity Biochemistry, 35, 1996
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9ICP
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9ICQ
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9ICG
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9ICM
| DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DOUBLE STRANDED DNA (NO 5'-PHOSPHATE) | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... | 著者 | Pelletier, H, Sawaya, M.R. | 登録日 | 1995-12-16 | 公開日 | 1996-11-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity Biochemistry, 35, 1996
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9ICU
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9ICH
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9ICY
| DNA POLYMERASE BETA (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA (NON GAPPED DNA ONLY) | 分子名称: | DNA (5'-D(*CP*AP*TP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... | 著者 | Pelletier, H, Sawaya, M.R. | 登録日 | 1996-10-24 | 公開日 | 1996-11-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity Biochemistry, 35, 1996
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9ICE
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9ICJ
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9ICX
| DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA (NON GAPPED DNA ONLY) | 分子名称: | DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*G)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... | 著者 | Pelletier, H, Sawaya, M.R. | 登録日 | 1996-10-24 | 公開日 | 1996-11-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity Biochemistry, 35, 1996
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9ICI
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4EFH
| Acanthamoeba Actin complex with Spir domain D | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-1, CALCIUM ION, ... | 著者 | Chen, C, Phillips, M, Sawaya, M.R, Quinlan, M.E. | 登録日 | 2012-03-29 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Multiple Forms of Spire-Actin Complexes and their Functional Consequences. J.Biol.Chem., 287, 2012
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4XFO
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4R0U
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7MPX
| CmcC E36G mutant from Type II Cut MCP | 分子名称: | BMC domain-containing protein, PHOSPHATE ION | 著者 | Ochoa, J.M, Acosta, A.A, Sawaya, M.R, Yeates, T.O. | 登録日 | 2021-05-05 | 公開日 | 2021-09-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments Acta Crystallogr.,Sect.F, 77, 2021
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7MPV
| CmcC from Type II Cut MCP | 分子名称: | BMC domain-containing protein | 著者 | Ochoa, J.M, Mijares, O, Sawaya, M.R, Yeates, T.O. | 登録日 | 2021-05-05 | 公開日 | 2021-09-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.292 Å) | 主引用文献 | Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments Acta Crystallogr.,Sect.F, 77, 2021
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