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PDB: 45 results

8A4I
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Crystal structure of SALL4 zinc finger cluster 4 with AT-rich DNA
Descriptor: DNA (5'-D(*GP*AP*TP*AP*TP*TP*AP*AP*TP*AP*TP*C)-3'), MAGNESIUM ION, Sal-like protein 4, ...
Authors:Watson, J.A, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A, Cook, A.G.
Deposit date:2022-06-11
Release date:2023-01-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.
Life Sci Alliance, 6, 2023
5FRG
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BU of 5frg by Molmil
The NMR Structure of the Cdc42-interacting region of TOCA1
Descriptor: FORMIN-BINDING PROTEIN 1-LIKE
Authors:Watson, J.R, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2015-12-17
Release date:2016-05-04
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Investigation of the Interaction between Cdc42 and its Effector Toca1: Handover of Cdc42 to the Actin Regulator N-Wasp is Facilitated by Differential Binding Affinities.
J.Biol.Chem., 291, 2016
1R7I
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BU of 1r7i by Molmil
HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION
Authors:Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2003-10-21
Release date:2003-11-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
1R31
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BU of 1r31 by Molmil
HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA
Descriptor: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ...
Authors:Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2003-09-30
Release date:2003-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
8DT0
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BU of 8dt0 by Molmil
Scaffolding protein functional sites using deep learning
Descriptor: Scaffolding protein functional sites
Authors:Bera, A.K, Watson, J, Baker, D.
Deposit date:2022-07-24
Release date:2022-08-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Scaffolding protein functional sites using deep learning.
Science, 377, 2022
8AYM
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BU of 8aym by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
8AYN
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BU of 8ayn by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
8AYL
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BU of 8ayl by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.
Deposit date:2022-09-02
Release date:2023-04-19
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
7OCE
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BU of 7oce by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCA
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BU of 7oca by Molmil
Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCC
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BU of 7occ by Molmil
NTD of resting state GluA1/A2 heterotertramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 1, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCD
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BU of 7ocd by Molmil
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCF
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BU of 7ocf by Molmil
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLOTHIAZIDE, GLUTAMIC ACID, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
2BER
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BU of 2ber by Molmil
Y370G Active Site Mutant of the Sialidase from Micromonospora viridifaciens in complex with beta-Neu5Ac (sialic acid).
Descriptor: BACTERIAL SIALIDASE, N-acetyl-beta-neuraminic acid, SODIUM ION
Authors:Newstead, S, Watson, J.N, Bennet, A.J, Taylor, G.L.
Deposit date:2004-11-30
Release date:2005-04-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Mechanism of Action of an Inverting Mutant Sialidase.
Biochemistry, 44, 2005
6H47
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BU of 6h47 by Molmil
Human KRAS in complex with darpin K19
Descriptor: GTPase KRas, SULFATE ION, darpin K19
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
6H46
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BU of 6h46 by Molmil
Human KRAS in complex with darpin K13
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
6P7K
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BU of 6p7k by Molmil
Structure of HMG-CoA reductase from Burkholderia cenocepacia
Descriptor: 3-hydroxy-3-methylglutaryl coenzyme A reductase, ADENOSINE-5'-DIPHOSPHATE, COENZYME A
Authors:Walker, A.M, Peacock, R.B, Hicks, C.W, Dewing, S.M, Lewis, K.M, Abboud, J, Stewart, S.W.A, Kang, C, Watson, J.M.
Deposit date:2019-06-05
Release date:2020-04-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.722 Å)
Cite:Structural and Functional Characterization of Dynamic Oligomerization in Burkholderia cenocepacia HMG-CoA Reductase.
Biochemistry, 58, 2019
7QHH
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BU of 7qhh by Molmil
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ...
Authors:Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H.
Deposit date:2021-12-12
Release date:2022-02-23
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
8AYO
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BU of 8ayo by Molmil
Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one, ...
Authors:Zhang, D, Lape, R, Shaikh, S, Kohegyi, B, Watson, J.F, Cais, O, Nakagawa, T, Greger, I.H.
Deposit date:2022-09-02
Release date:2023-04-19
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.
Nat Commun, 14, 2023
1ZEY
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BU of 1zey by Molmil
CGG A-DNA
Descriptor: 5'-D(*CP*CP*CP*CP*GP*CP*GP*GP*GP*G)-3', SODIUM ION
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-19
Release date:2005-05-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZF6
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BU of 1zf6 by Molmil
TGG DUPLEX A-DNA
Descriptor: 5'-D(*CP*CP*CP*CP*AP*TP*GP*GP*GP*G)-3', CALCIUM ION, SODIUM ION
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-19
Release date:2005-05-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZEX
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BU of 1zex by Molmil
CCG A-DNA
Descriptor: 5'-D(*CP*CP*CP*GP*GP*CP*CP*GP*GP*G)-3'
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-19
Release date:2005-05-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZF2
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BU of 1zf2 by Molmil
Four-stranded DNA Holliday Junction (CCC)
Descriptor: 5'-D(*CP*CP*GP*GP*GP*CP*CP*CP*GP*G)-3'
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-19
Release date:2005-05-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZFC
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BU of 1zfc by Molmil
ATC Duplex B-DNA
Descriptor: 5'-D(*CP*CP*GP*AP*TP*AP*TP*CP*GP*G)-3'
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-20
Release date:2005-05-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZEW
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BU of 1zew by Molmil
B-DNA
Descriptor: 5'-D(*CP*CP*TP*CP*TP*AP*GP*AP*GP*G)-3', SODIUM ION
Authors:Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S.
Deposit date:2005-04-19
Release date:2005-05-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005

 

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