8AYO

Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059

Summary for 8AYO

• Entry DOI: 10.2210/pdb8ayo/pdb
• EMDB information: 15718
• Descriptor: Isoform Flip of Glutamate receptor 1, Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-8 subunit, ... (9 entities in total)
• Functional Keywords: ampar, ion channels, neurotransmission, membrane protein
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 493515.50

Authors

Zhang, D.,Lape, R.,Shaikh, S.,Kohegyi, B.,Watson, J.F.,Cais, O.,Nakagawa, T.,Greger, I.H. (deposition date: 2022-09-02, release date: 2023-04-19, Last modification date: 2023-05-24)

• Primary citation: Zhang, D.,Lape, R.,Shaikh, S.A.,Kohegyi, B.K.,Watson, J.F.,Cais, O.,Nakagawa, T.,Greger, I.H.; Modulatory mechanisms of TARP gamma 8-selective AMPA receptor therapeutics.; Nat Commun, 14:1659-1659, 2023; PubMed: 36966141; DOI: 10.1038/s41467-023-37259-5

Experimental method

ELECTRON MICROSCOPY (3.3 Å)