8AYO
Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform Flip of Glutamate receptor 1 | polymer | 915 | 102661.9 | 2 | UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1 |
| 2 | B, F (D, B) | Isoform Flip of Glutamate receptor 2 | polymer | 860 | 96247.1 | 2 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 3 | D, E (I, J) | Voltage-dependent calcium channel gamma-8 subunit | polymer | 423 | 43576.0 | 2 | UniProt (Q8VHW5) Pfam (PF00822) | Rattus norvegicus (Norway rat) | Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8 |
| 4 | DA, G, M, P (B, A, D, C) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 5 | EA, H, N, Q (B, A, D, C) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
| 6 | FA, I, O, R (B, A, D, C) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 4 | Chemie (OLC) | |||
| 7 | AA, BA, J, K, S... (J, A, C, I) | PALMITIC ACID | non-polymer | 256.4 | 10 | Chemie (PLM) | |||
| 8 | L, U (A, C) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 2 | Chemie (POV) | |||
| 9 | CA, W (J, I) | 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one | non-polymer | 443.5 | 2 | Chemie (OIJ) |
Sequence modifications
A, C: -25 - 889 (UniProt: P19490)
D, B: -20 - 839 (UniProt: P19491)
I, J: 2 - 417 (UniProt: Q8VHW5)
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | insertion |
| Tyr -5 | - | insertion |
| Lys -4 | - | insertion |
| Asp -3 | - | insertion |
| Asp -2 | - | insertion |
| Asp -1 | - | insertion |
| Asp 0 | - | insertion |
| Lys 1 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Leu 418 | - | expression tag |
| Glu 419 | - | expression tag |
| Val 420 | - | expression tag |
| Leu 421 | - | expression tag |
| Phe 422 | - | expression tag |
| Gln 423 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 484970.0 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 8545.5 | |
| All* | Total formula weight | 493515.5 |
