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PDB: 910 件
7U2L
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BU of 7u2l by Molmil
C5guano-uOR-Gi-scFv16
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, H, Qu, Q, Skiniotis, G, Kobilka, B.
登録日2022-02-24
公開日2022-05-04
最終更新日2023-02-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
7U2K
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C6-guano bound Mu Opioid Receptor-Gi Protein Complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, H, Kobilka, B.
登録日2022-02-24
公開日2022-12-07
最終更新日2023-02-08
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
5YQM
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Crystal structure of Sirt2 in complex with selective inhibitor A29
分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.735 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
3KH8
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BU of 3kh8 by Molmil
Crystal structure of MaoC-like dehydratase from Phytophthora Capsici
分子名称: MaoC-like dehydratase
著者Wang, H, Zhang, K, Guo, J, Zhou, Q, Zheng, X, Sun, F, Pang, H, Zhang, X.
登録日2009-10-30
公開日2010-11-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of MaoC-like dehydratase from Phytophthora Capsici
To be Published
3WOH
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BU of 3woh by Molmil
Structure of Ketoreductase SiaM from Streptomyces sp. A7248
分子名称: SiaM
著者Wang, H, Zhang, H.
登録日2013-12-29
公開日2014-08-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces
Plos One, 9, 2014
1ZS9
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BU of 1zs9 by Molmil
Crystal structure of human enolase-phosphatase E1
分子名称: E-1 ENZYME, MAGNESIUM ION
著者Wang, H, Pang, H, Bartlam, M, Rao, Z.
登録日2005-05-23
公開日2005-06-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Human E1 Enzyme and its Complex with a Substrate Analog Reveals the Mechanism of its Phosphatase/Enolase
J.Mol.Biol., 348, 2005
4MMC
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BU of 4mmc by Molmil
Crystal structure of LeuBAT (delta6 mutant) in complex with desvenlafaxine
分子名称: 4-[(1R)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, SODIUM ION, Transporter, ...
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
1WWS
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BU of 1wws by Molmil
Crystal structure of ttk003001566 from Thermus Thermophilus HB8
分子名称: CALCIUM ION, hypothetical protein TTHA1479
著者Wang, H, Murayama, K, Terada, T, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-01-18
公開日2006-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of ttk003001566 from Thermus Thermophilus HB8
to be published
3ECM
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BU of 3ecm by Molmil
Crystal structure of the unliganded PDE8A catalytic domain
分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ZINC ION
著者Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H.
登録日2008-09-01
公開日2008-11-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
5YQN
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BU of 5yqn by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor L55
分子名称: DI(HYDROXYETHYL)ETHER, N-[3-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
4MM8
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BU of 4mm8 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with (R)-fluoxetine
分子名称: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MM9
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Crystal structure of LeuBAT (delta13 mutant) in complex with fluvoxamine
分子名称: Fluvoxamine, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
6VCD
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BU of 6vcd by Molmil
Cryo-EM structure of IRP2-FBXL5-SKP1 complex
分子名称: F-box/LRR-repeat protein 5, FE2/S2 (INORGANIC) CLUSTER, Iron-responsive element binding protein 2, ...
著者Wang, H, Shi, H, Zheng, N.
登録日2019-12-20
公開日2020-08-05
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Mol.Cell, 78, 2020
5YQO
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BU of 5yqo by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor L5C
分子名称: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.483 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
5YQL
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BU of 5yql by Molmil
Crystal structure of Sirt2 in complex with selective inhibitor A2I
分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, H, Yu, Y, Li, G, Chen, Q.
登録日2017-11-07
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Eur J Med Chem, 155, 2018
3B54
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BU of 3b54 by Molmil
Saccharomyces cerevisiae nucleoside diphosphate kinase
分子名称: Nucleoside diphosphate kinase, PHOSPHATE ION
著者Wang, H.B, Bao, R, Cheng, Y.X.
登録日2007-10-25
公開日2008-10-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of Ynk1 from the yeast Saccharomyces cerevisiae
Acta Crystallogr.,Sect.F, 64, 2008
4MM5
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BU of 4mm5 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with sertraline
分子名称: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MMB
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BU of 4mmb by Molmil
Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline
分子名称: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ...
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MMA
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BU of 4mma by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with clomipramine
分子名称: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MM6
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BU of 4mm6 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with (S)-duloxetine
分子名称: (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
4MM7
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BU of 4mm7 by Molmil
Crystal structure of LeuBAT (delta13 mutant) in complex with desvenlafaxine
分子名称: 4-[(1R)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2013-09-08
公開日2013-10-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
2DTC
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BU of 2dtc by Molmil
Crystal structure of MS0666
分子名称: RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR RALGPS1A
著者Wang, H, Kishishita, S, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-07-12
公開日2007-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of MS0666
To be Published
2NZ0
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BU of 2nz0 by Molmil
Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1
分子名称: CALCIUM ION, Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, ...
著者Wang, H, Yan, Y, Shen, Y, Chen, L, Wang, K.
登録日2006-11-22
公開日2006-12-26
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
4ZYO
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BU of 4zyo by Molmil
Crystal Structure of Human Integral Membrane Stearoyl-CoA Desaturase with Substrate
分子名称: Acyl-CoA desaturase, DODECYL-BETA-D-MALTOSIDE, STEAROYL-COENZYME A, ...
著者Wang, H, Klein, M.G, Lane, W, Snell, G, Levin, I, Li, K, Zou, H, Sang, B.-C.
登録日2015-05-21
公開日2015-06-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate.
Nat.Struct.Mol.Biol., 22, 2015
5Z3W
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BU of 5z3w by Molmil
Malate dehydrogenase binds silver at C113
分子名称: Malate dehydrogenase, SILVER ION
著者Wang, H, Wang, M, Sun, H.
登録日2018-01-09
公開日2019-01-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm
Chem Sci, 2020

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