6VCD
Cryo-EM structure of IRP2-FBXL5-SKP1 complex
Summary for 6VCD
Entry DOI | 10.2210/pdb6vcd/pdb |
EMDB information | 21149 |
Descriptor | Iron-responsive element binding protein 2, isoform CRA_a, F-box/LRR-repeat protein 5, S-phase kinase-associated protein 1, ... (4 entities in total) |
Functional Keywords | e3 ligase, [2fe-2s] cluster, iron metabolism, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 178853.55 |
Authors | |
Primary citation | Wang, H.,Shi, H.,Rajan, M.,Canarie, E.R.,Hong, S.,Simoneschi, D.,Pagano, M.,Bush, M.F.,Stoll, S.,Leibold, E.A.,Zheng, N. FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. Mol.Cell, 78:31-41.e5, 2020 Cited by PubMed: 32126207DOI: 10.1016/j.molcel.2020.02.011 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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