6VCD

Cryo-EM structure of IRP2-FBXL5-SKP1 complex

Summary for 6VCD

Entry DOI	10.2210/pdb6vcd/pdb
EMDB information	21149
Descriptor	Iron-responsive element binding protein 2, isoform CRA_a, F-box/LRR-repeat protein 5, S-phase kinase-associated protein 1, ... (4 entities in total)
Functional Keywords	e3 ligase, [2fe-2s] cluster, iron metabolism, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	178853.55
Authors	Wang, H.,Shi, H.,Zheng, N. (deposition date: 2019-12-20, release date: 2020-08-05, Last modification date: 2024-03-06)
Primary citation	Wang, H.,Shi, H.,Rajan, M.,Canarie, E.R.,Hong, S.,Simoneschi, D.,Pagano, M.,Bush, M.F.,Stoll, S.,Leibold, E.A.,Zheng, N. FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. Mol.Cell, 78:31-41.e5, 2020 Cited by PubMed: 32126207 DOI: 10.1016/j.molcel.2020.02.011 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation