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PDB: 1554 件
1T8P
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Crystal structure of Human erythrocyte 2,3-bisphosphoglycerate mutase
分子名称: Bisphosphoglycerate mutase
著者Wang, Y, Wei, Z, Bian, Q, Cheng, Z, Wan, M, Liu, L, Gong, W.
登録日2004-05-13
公開日2004-08-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human bisphosphoglycerate mutase
J.Biol.Chem., 279, 2004
5ZRX
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Crystal Structure of EphA2/SHIP2 Complex
分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2
著者Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
登録日2018-04-25
公開日2018-05-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRY
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Crystal Structure of EphA6/Odin Complex
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, ...
著者Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
登録日2018-04-25
公開日2018-05-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRZ
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Crystal Structure of EphA5/SAMD5 Complex
分子名称: Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5
著者Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M.
登録日2018-04-25
公開日2018-05-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
6CDJ
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HIV-1 wild type protease with GRL-03314A, 6-5-5-ring fused umbrella-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand
分子名称: (2aS,4R,4aS,7aS,7bS)-octahydro-2H-1,7-dioxacyclopenta[cd]inden-4-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ...
著者Wang, Y.-F, Agniswamy, J, Weber, I.T.
登録日2018-02-08
公開日2018-05-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
J. Med. Chem., 61, 2018
5UOV
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HIV-1 wild Type protease with GRL-1118A , an isophthalamide-derived P2-P3 ligand with the sulfonamide isostere as the P2' group
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Wang, Y.-F, Agniswamy, J, Weber, I.T.
登録日2017-02-01
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg. Med. Chem., 25, 2017
6CCY
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Crystal structure of Akt1 in complex with a selective inhibitor
分子名称: (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one, RAC-alpha serine/threonine-protein kinase,PIFtide
著者Wang, Y, Stout, S.
登録日2018-02-07
公開日2018-05-02
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018
5UPZ
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HIV-1 wild Type protease with GRL-0518A , an isophthalamide-derived P2-P3 ligand with the para-hydoxymethyl sulfonamide isostere as the P2' group
分子名称: CHLORIDE ION, GLYCEROL, N~3~-{(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}-N~1~-methyl-N~1~-[(4-methyl-1,3-oxazol-2-yl)methyl]benzene-1,3-dicarboxamide, ...
著者Wang, Y.-F, Agniswamy, J, Weber, I.T.
登録日2017-02-05
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg. Med. Chem., 25, 2017
3F73
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Alignment of guide-target seed duplex within an argonaute silencing complex
分子名称: ARGONAUTE, DNA (5'-D(P*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DA*DTP*DAP*DGP*DT)-3'), MAGNESIUM ION, ...
著者Wang, Y, Li, H, Sheng, G, Juranek, S, Tuschl, T, Patel, D.J.
登録日2008-11-07
公開日2008-12-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.
Nature, 456, 2008
9B2H
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HIV-1 wild type protease with GRL-072-17A, a substituted tetrahydrofuran derivative based on Darunavir as P2 group
分子名称: 2,5:6,9-dianhydro-1,3,7,8-tetradeoxy-4-O-({(2S,3R)-3-hydroxy-4-[(4-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamoyl)-L-gluco-nonitol, CHLORIDE ION, FORMIC ACID, ...
著者Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T.
登録日2024-03-15
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies.
Org.Biomol.Chem., 2024
5UJT
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Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-beta-1, ...
著者Wang, Y, Dai, S.
登録日2017-01-18
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8HWI
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Bacterial STING from Larkinella arboricola in complex with 3'3'-c-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12
著者Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
登録日2022-12-30
公開日2024-01-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
8HY8
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Bacterial STING from Epilithonimonas lactis
分子名称: CD-NTase-associated protein 12
著者Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
登録日2023-01-06
公開日2024-01-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.568 Å)
主引用文献Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
8HYA
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Cryo-EM structure of Arabidopsis thaliana SOS1 in an occluded state, with expanded TMD
分子名称: HEXADECANE, Sodium/hydrogen exchanger 7
著者Wang, Y, Zhao, Y, Gao, Y.
登録日2023-01-06
公開日2023-08-09
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Architecture and autoinhibitory mechanism of the plasma membrane Na + /H + antiporter SOS1 in Arabidopsis.
Nat Commun, 14, 2023
8HYN
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Bacterial STING from Riemerella anatipestifer
分子名称: CD-NTase-associated protein 12, TETRAETHYLENE GLYCOL
著者Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
登録日2023-01-07
公開日2024-01-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.089 Å)
主引用文献Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
8HWJ
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Bacterial STING from Epilithonimonas lactis in complex with 3'3'-c-di-AMP
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CD-NTase-associated protein 12
著者Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
登録日2022-12-30
公開日2024-01-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.553 Å)
主引用文献Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
8HY9
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Bacterial STING from Riemerella anatipestifer in complex with 3'3'-c-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, CD-NTase-associated protein 12
著者Wang, Y.-C, Yang, C.-S, Hou, M.-H, Chen, Y.
登録日2023-01-06
公開日2024-01-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.462 Å)
主引用文献Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.
Nat Commun, 14, 2023
8WRZ
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Cry-EM structure of cannabinoid receptor-arrestin 2 complex
分子名称: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Beta-arrestin-1, Soluble cytochrome b562,Cannabinoid receptor 1, ...
著者Wang, Y.X, Wang, T, Wu, L.J, Hua, T, Liu, Z.J.
登録日2023-10-16
公開日2024-02-28
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structure of cannabinoid receptor CB1-beta-arrestin complex.
Protein Cell, 15, 2024
8HY7
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EGFR kinase domain mutant "TMLR" with compound 28f
分子名称: Epidermal growth factor receptor, ~{N}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide
著者Wang, Y.X, Wu, C.Y.
登録日2023-01-06
公開日2023-08-23
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献The crystal structure of EGFR kinase domain(T790M/L858R) in complex with compound 28f
To Be Published
143D
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SOLUTION STRUCTURE OF THE HUMAN TELOMERIC REPEAT D(AG3[T2AG3]3) OF THE G-QUADRUPLEX
分子名称: DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3')
著者Wang, Y, Patel, D.J.
登録日1993-10-08
公開日1994-04-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex.
Structure, 1, 1993
3ZG6
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The novel de-long chain fatty acid function of human sirt6
分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, GLYCEROL, NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6, ...
著者Wang, Y, Hao, Q.
登録日2012-12-15
公開日2013-04-03
最終更新日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine
Nature, 496, 2013
8I2B
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Human SIRT6 in complex with inhibitor 7702
分子名称: N1-[[4-(4-aminophenyl)sulfanyl-3-(trifluoromethyl)phenyl]methoxy]benzene-1,4-dicarboxamide, NAD-dependent protein deacylase sirtuin-6, SULFATE ION, ...
著者Wang, Y.
登録日2023-01-14
公開日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The SIRT6 in complex with inhibitor 7702
To Be Published
6J07
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Crystal structure of human TERB2 and TERB1
分子名称: Telomere repeats-binding bouquet formation protein 1, Telomere repeats-binding bouquet formation protein 2, ZINC ION
著者Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M.
登録日2018-12-21
公開日2019-02-27
実験手法X-RAY DIFFRACTION (3.298 Å)
主引用文献The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
2I0G
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Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
分子名称: (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL, Estrogen receptor beta
著者Wang, Y.
登録日2006-08-10
公開日2006-10-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
J.Med.Chem., 49, 2006
2IMI
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Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity
分子名称: Epsilon-class Glutathione S-transferase, GLUTATHIONE
著者Wang, Y, Hemingway, J, Ranson, H, Meehan, E.J, Chen, L.
登録日2006-10-02
公開日2007-10-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
J.Struct.Biol., 164, 2008

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