9B2H
HIV-1 wild type protease with GRL-072-17A, a substituted tetrahydrofuran derivative based on Darunavir as P2 group
This is a non-PDB format compatible entry.
Summary for 9B2H
Entry DOI | 10.2210/pdb9b2h/pdb |
Related | 2IEN 3NU3 |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | aspartic acid protease, hiv-1 protease, darunavir, a substituted tetrahydrofuran derivative inhibitor, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22504.11 |
Authors | Wang, Y.-F.,Agniswamy, J.,Ghosh, A.K.,Weber, I.T. (deposition date: 2024-03-15, release date: 2024-07-24) |
Primary citation | Ghosh, A.K.,Lee, D.,Sharma, A.,Johnson, M.E.,Ghosh, A.K.,Wang, Y.F.,Agniswamy, J.,Amano, M.,Hattori, S.I.,Weber, I.T.,Mitsuya, H. Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. Org.Biomol.Chem., 2024 Cited by PubMed: 38973505DOI: 10.1039/d4ob00506f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)