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PDB: 672 件
7YPJ
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Spiral pentamer of the substrate-free Lon protease with a S678A mutation
分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease
著者Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
登録日2022-08-03
公開日2023-10-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPK
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Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation
分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein
著者Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
登録日2022-08-03
公開日2023-10-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPI
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Spiral hexamer of the substrate-free Lon protease with a Y224S mutation
分子名称: Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
登録日2022-08-03
公開日2023-10-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPH
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Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation
分子名称: Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
登録日2022-08-03
公開日2023-10-25
最終更新日2023-11-29
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
1YBJ
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BU of 1ybj by Molmil
Structural and Dynamics studies of both apo and holo forms of the hemophore HasA
分子名称: Hemophore HasA
著者Wolff, N, Izadi-Pruneyre, N, Couprie, J, Habeck, M, Linge, J, Rieping, W, Wandersman, C, Nilges, M, Delepierre, M, Lecroisey, A.
登録日2004-12-21
公開日2005-12-27
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Comparative analysis of structural and dynamic properties of the loaded and unloaded hemophore HasA: functional implications.
J.Mol.Biol., 376, 2008
2L8L
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Structure of an engineered splicing intein mutant based on Mycobacterium tuberculosis RecA
分子名称: Endonuclease PI-MtuI
著者Du, Z, Wang, C.
登録日2011-01-19
公開日2012-01-04
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献pK(a) coupling at the intein active site: implications for the coordination mechanism of protein splicing with a conserved aspartate.
J.Am.Chem.Soc., 133, 2011
1SMP
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN SERRATIA MARCESCENS METALLO-PROTEASE AND AN INHIBITOR FROM ERWINIA CHRYSANTHEMI
分子名称: CALCIUM ION, ERWINIA CHRYSANTHEMI INHIBITOR, SERRATIA METALLO PROTEINASE, ...
著者Baumann, U, Bauer, M, Letoffe, S, Delepelaire, P, Wandersman, C.
登録日1995-01-13
公開日1996-04-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi.
J.Mol.Biol., 248, 1995
2MN1
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Solution Structure of kalata B1[W23WW]
分子名称: kalata B1[W23WW]
著者Henriques, S.T, Huang, Y.H, Chaousis, S, Wang, C.K, Craik, D.J.
登録日2014-03-26
公開日2015-05-27
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting.
Chembiochem, 15, 2014
7XIJ
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Crystal structure of CBP bromodomain liganded with Y08175
分子名称: 3-[(1-ethanoyl-5-methoxy-indol-3-yl)carbonylamino]-4-fluoranyl-5-(1-methylpyrazol-4-yl)benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Xiang, Q, Wang, C, Wu, T, Zhang, Y, Zhang, C, Luo, G, Wu, X, Shen, H, Xu, Y.
登録日2022-04-13
公開日2022-06-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Crystal structure of CBP bromodomain liganded with Y08175
To Be Published
7XNE
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Crystal structure of CBP bromodomain liganded with Y08284
分子名称: CREB-binding protein, GLYCEROL, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide
著者Xiang, Q, Wang, C, Wu, T, Zhang, C, Hu, Q, Luo, G, Hu, J, Zhuang, X, Zou, L, Shen, H, Wu, X, Zhang, Y, Kong, X, Xu, Y.
登録日2022-04-28
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J.Med.Chem., 65, 2022
2CN4
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The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand
分子名称: HEMOPHORE HASA, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE
著者Czjzek, M, Letoffe, S, Wandersman, C, Delepierre, M, Lecroisey, A, Izadi-Pruneyre, N.
登録日2006-05-18
公開日2006-05-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of the Secreted Dimeric Form of the Hemophore Hasa Reveals a Domain Swapping with an Exchanged Heme Ligand
J.Mol.Biol., 365, 2007
4QSZ
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BU of 4qsz by Molmil
Crystal structure of mouse JMJd7 fused with maltose-binding protein
分子名称: CITRATE ANION, Maltose-binding periplasmic protein, JmjC domain-containing protein 7 chimera, ...
著者Liu, H, Wang, C, Zhang, G.Y.
登録日2014-07-06
公開日2015-07-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Crystal structure of mouse JMJd7 fused with maltose-binding protein
To be Published
7XHE
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Crystal structure of CBP bromodomain liganded with CCS151
分子名称: (6S)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]-1-(3-fluoranyl-4-methoxy-phenyl)piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein
著者Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
登録日2022-04-08
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
7XH6
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Crystal structure of CBP bromodomain liganded with CCS1477
分子名称: (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, CREB-binding protein, DIMETHYL SULFOXIDE, ...
著者Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
登録日2022-04-07
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
7XI0
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Crystal structure of CBP bromodomain liganded with CCS150
分子名称: (6S)-1-(3-chloranyl-4-methoxy-phenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]piperidin-2-one, CREB-binding protein, GLYCEROL
著者Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y.
登録日2022-04-11
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain
Biochem.Biophys.Res.Commun., 623, 2022
7XH3
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Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2
分子名称: DNA (5'-D(*CP*CP*GP*GP*GP*TP*AP*CP*CP*CP*GP*G)-3')
著者Zhang, Y, Lan, W, Wang, C, Cao, C.
登録日2022-04-07
公開日2023-02-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Dimeric G-quadruplex DNA Structure in the Proximal Promoter of VEGFR-2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis.
Chin.J.Chem., 40, 2022
7XFV
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Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2
分子名称: DNA (5'-D(*AP*TP*GP*AP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3')
著者Zhang, Y, Lan, W, Wang, C, Cao, C.
登録日2022-04-02
公開日2023-03-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Dimeric G-quadruplex DNA Structure in the Proximal Promoter of VEGFR-2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis.
Chin.J.Chem., 40, 2023
7XYR
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BU of 7xyr by Molmil
Cystal Structure of Beta-glucuronidase from Bacteroides thetaiotaomicron
分子名称: Beta-glucuronidase, GLYCEROL, MAGNESIUM ION, ...
著者Teng, X, Wang, C.
登録日2022-06-02
公開日2023-07-05
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cystal Structure of Beta-glucuronidase from Bacteroides thetaiotaomicron
To Be Published
7XNG
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Crystal structure of CBP bromodomain liganded with Y08092(31g)
分子名称: 3-[(1-ethanoylindol-3-yl)carbonylamino]-5-[[(2S)-oxan-2-yl]oxymethyl]benzoic acid, CREB-binding protein, DI(HYDROXYETHYL)ETHER, ...
著者Xiang, Q, Zhang, Y, Wang, C, Song, M, Xu, Y.
登録日2022-04-28
公開日2022-06-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of CBP bromodomain liganded with Y08092(31g)
To Be Published
7XM7
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Crystal Structure of the CBP in complex with the Y08188
分子名称: 1,2-ETHANEDIOL, 3-ethanoyl-~{N}-[2-fluoranyl-3-(1-methylpyrazol-4-yl)phenyl]-7-methoxy-indolizine-1-carboxamide, CREB-binding protein, ...
著者Xiang, Q, Zhang, Y, Wang, C, Song, M, Xu, Y.
登録日2022-04-25
公開日2022-06-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors
To Be Published
7XCE
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Crystal structure of Ankyrin G in complex with neurofascin
分子名称: GLYCEROL, Neurofascin,Ankyrin-3, SULFATE ION
著者He, L, Li, J, Wang, C.
登録日2022-03-24
公開日2022-09-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment.
J.Biol.Chem., 298, 2022
3TA9
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beta-Glucosidase A from the halothermophile H. orenii
分子名称: Glycoside hydrolase family 1, NICKEL (II) ION
著者Hofmann, A, Wang, C.K, Kori, L.D, Patel, B.K.
登録日2011-08-03
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Expression, purification and preliminary crystallographic analysis of the recombinant (beta)-glucosidase (BglA) from the halothermophile Halothermothrix orenii
Acta Crystallogr.,Sect.F, 67, 2011

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