3C2S
 
 | | Structural Characterization of a Human Fc Fragment Engineered for Lack of Effector Functions | | 分子名称: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | | 登録日 | 2008-01-25 | | 公開日 | 2008-08-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural characterization of a human Fc fragment engineered for lack of effector functions.
Acta Crystallogr.,Sect.D, 64, 2008
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3PAK
 | | Crystal Structure of Rat Surfactant Protein A neck and carbohydrate recognition domain (NCRD) complexed with Mannose | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SODIUM ION, ... | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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6KW3
 | | The ClassA RSC-Nucleosome Complex | | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | | 登録日 | 2019-09-05 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (7.13 Å) | | 主引用文献 | Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
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3PAQ
 | | Surfactant Protein A neck and carbohydrate recognition domain (NCRD) complexed with alpha-methylmannose | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SODIUM ION, ... | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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3QAK
 | | Agonist bound structure of the human adenosine A2a receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,lysozyme chimera | | 著者 | Xu, F, Wu, H, Katritch, V, Han, G.W, Cherezov, V, Stevens, R, GPCR Network (GPCR) | | 登録日 | 2011-01-11 | | 公開日 | 2011-03-09 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011
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2PKU
 | | Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 | | 分子名称: | PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE) | | 著者 | Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M. | | 登録日 | 2007-04-18 | | 公開日 | 2007-11-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
Embo J., 26, 2007
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6L62
 | | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | | 分子名称: | Capsid protein, Heavy chain of Fab fragment, Light chain of Fab fragment | | 著者 | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | | 登録日 | 2019-10-25 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-04-29 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
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3PAR
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, SULFATE ION | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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5UPD
 | | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) | | 分子名称: | Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... | | 著者 | Tempel, W, Yu, W, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2017-02-02 | | 公開日 | 2017-02-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
To Be Published
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6LM3
 | | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | | 分子名称: | Capsid protein | | 著者 | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | | 主引用文献 | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
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2PON
 | | Solution structure of the Bcl-xL/Beclin-1 complex | | 分子名称: | Apoptosis regulator Bcl-X, Beclin-1 | | 著者 | Feng, W, Huang, S, Wu, H, Zhang, M. | | 登録日 | 2007-04-27 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Basis of Bcl-xL's Target Recognition Versatility Revealed by the Structure of Bcl-xL in Complex with the BH3 Domain of Beclin-1.
J.Mol.Biol., 372, 2007
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6KW4
 | | The ClassB RSC-Nucleosome Complex | | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | | 登録日 | 2019-09-06 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (7.55 Å) | | 主引用文献 | Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
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3PBF
 | | Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) complexed with glycerol | | 分子名称: | CALCIUM ION, GLYCEROL, Pulmonary surfactant-associated protein A | | 著者 | Shang, F, Rynkiewicz, M.J, McCormack, F.X, Wu, H, Cafarella, T.M, Head, J, Seaton, B.A. | | 登録日 | 2010-10-20 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change.
J.Biol.Chem., 286, 2011
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6K15
 | | RSC substrate-recruitment module | | 分子名称: | Chromatin structure-remodeling complex protein RSC3, Chromatin structure-remodeling complex protein RSC30, Chromatin structure-remodeling complex protein RSC58, ... | | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | | 登録日 | 2019-05-09 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
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2OGP
 | | Solution structure of the second PDZ domain of Par-3 | | 分子名称: | Partitioning-defective 3 homolog | | 著者 | Feng, W, Wu, H, Chen, J, Chan, L.-N, Zhang, M. | | 登録日 | 2007-01-07 | | 公開日 | 2007-12-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | PDZ domains of par-3 as potential phosphoinositide signaling integrators
Mol.Cell, 28, 2007
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2MB9
 | | Human Bcl10 CARD | | 分子名称: | B-cell lymphoma/leukemia 10 | | 著者 | Zheng, C, Bracken, C, Wu, H. | | 登録日 | 2013-07-26 | | 公開日 | 2013-10-16 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.
Mol.Cell, 51, 2013
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5FFS
 | | Crystal Structure of Surfactant Protein-A Y164A Mutant | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A | | 著者 | Goh, B.C, Wu, H, Rynkiewicz, M.J, Schulten, K, Seaton, B.A, McCormack, F.X. | | 登録日 | 2015-12-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.
Biochemistry, 55, 2016
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5FFT
 | | Crystal Structure of Surfactant Protein-A Y221A Mutant | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A | | 著者 | Goh, B.C, Wu, H, Rynkiewicz, M.J, Schulten, K, Seaton, B.A, McCormack, F.X. | | 登録日 | 2015-12-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.
Biochemistry, 55, 2016
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6BZE
 | | Cryo-EM structure of BCL10 CARD filament | | 分子名称: | B-cell lymphoma/leukemia 10 | | 著者 | David, L, Li, Y, Ma, J, Garner, E, Zhang, X, Wu, H. | | 登録日 | 2017-12-23 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5FFR
 | | Crystal Structure of Surfactant Protein-A complexed with phosphocholine | | 分子名称: | CALCIUM ION, PHOSPHOCHOLINE, Pulmonary surfactant-associated protein A, ... | | 著者 | Goh, B.C, Wu, H, Rynkiewicz, M.J, Schulten, K, Seaton, B.A, McCormack, F.X. | | 登録日 | 2015-12-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.
Biochemistry, 55, 2016
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4N0F
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4WUX
 | | Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D) Complexed with Mannose | | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A, alpha-D-mannopyranose | | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | | 登録日 | 2014-11-03 | | 公開日 | 2016-02-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop
To be published
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6NCV
 | | Cryo-EM structure of NLRP6 PYD filament | | 分子名称: | NACHT, LRR and PYD domains-containing protein 6 | | 著者 | Shen, C, Fu, T.M, Wu, H. | | 登録日 | 2018-12-12 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7WG3
 | | Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D9 Fab, IL17RB protein, ... | | 著者 | Lee, W.H, Chen, X.R, Liu, I.J, Lee, J.H, Hu, C.M, Wu, H.C, Wang, S.K, Lee, W.H, Ma, C. | | 登録日 | 2021-12-28 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation.
Cell Rep, 41, 2022
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4JKV
 | | Structure of the human smoothened 7TM receptor in complex with an antitumor agent | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Wang, C, Wu, H, Katritch, V, Han, G.W, Huang, X, Liu, W, Siu, F.Y, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | | 登録日 | 2013-03-11 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure of the human smoothened receptor bound to an antitumour agent.
Nature, 497, 2013
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