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PDB: 887 件
6D0U
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BU of 6d0u by Molmil
Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 V110P/A117E mutant, heavy chain, ...
著者Wu, N.C, Wilson, I.A.
登録日2018-04-11
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CF7
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BU of 6cf7 by Molmil
Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Kadam, R.U, Wilson, I.A.
登録日2018-02-13
公開日2019-02-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science, 363, 2019
6CXL
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anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5
分子名称: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, anti-HIV-1 Fab 2G12 heavy chain, anti-HIV-1 Fab 2G12 light chain
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.586 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
6D2P
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BU of 6d2p by Molmil
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
分子名称: GLYCEROL, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, ...
著者Sarkar, A, Wilson, I.A.
登録日2018-04-13
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Sci Transl Med, 10, 2018
6CXG
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BU of 6cxg by Molmil
anti-HIV-1 Fab 2G12 in complex with glycopeptide 10V1S
分子名称: 10V1S glycopeptide, GLYCEROL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, ...
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
1F58
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IGG1 FAB FRAGMENT (58.2) COMPLEX WITH 24-RESIDUE PEPTIDE (RESIDUES 308-333 OF HIV-1 GP120 (MN ISOLATE) WITH ALA TO AIB SUBSTITUTION AT POSITION 323
分子名称: Envelope glycoprotein gp120, PROTEIN (IGG1 ANTIBODY 58.2 (HEAVY CHAIN)), PROTEIN (IGG1 ANTIBODY 58.2 (LIGHT CHAIN))
著者Stanfield, R.L, Cabezas, E, Satterthwait, A.C, Stura, E.A, Profy, A.T, Wilson, I.A.
登録日1998-10-21
公開日1999-02-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.
Structure Fold.Des., 7, 1999
1RC1
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BU of 1rc1 by Molmil
Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID, PHOSPHATE ION, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Human GAR Tfase complex structure
To be Published
1RC0
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BU of 1rc0 by Molmil
Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Human GAR Tfase complex structure
To be Published
1U9K
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Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76
分子名称: ZINC ION, triggering receptor expressed on myeloid cells 1
著者Kelker, M.S, Debler, E.W, Wilson, I.A.
登録日2004-08-09
公開日2004-12-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76A
J.Mol.Biol., 344, 2004
1TZG
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BU of 1tzg by Molmil
Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41
分子名称: Envelope polyprotein GP160, Fab 4E10, GLYCEROL
著者Cardoso, R.M.F, Zwick, M.B, Stanfield, R.L, Kunert, R, Binley, J.M, Katinger, H, Burton, D.R, Wilson, I.A.
登録日2004-07-09
公開日2005-03-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
Immunity, 22, 2005
5J74
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BU of 5j74 by Molmil
Fluorogen activating protein AM2.2 in complex with TO1-2p
分子名称: 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium, PHOSPHATE ION, scFv AM2.2
著者Stanfield, R.L, Wilson, I.A, Wu, Y.
登録日2016-04-05
公開日2016-05-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.
J Biomol Screen, 21, 2016
1RBZ
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BU of 1rbz by Molmil
Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human GAR Tfase complex structure
To be Published
1RD8
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BU of 1rd8 by Molmil
Crystal Structure of the 1918 Human H1 Hemagglutinin Precursor (HA0)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Stevens, J, Corper, A.L, Basler, C.F, Taubenberger, J.K, Palese, P, Wilson, I.A.
登録日2003-11-05
公開日2004-03-23
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus.
Science, 303, 2004
1U7D
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BU of 1u7d by Molmil
crystal structure of apo M. jannashii tyrosyl-tRNA synthetase
分子名称: Tyrosyl-tRNA synthetase
著者Zhang, Y, Wang, L, Schultz, P.G, Wilson, I.A.
登録日2004-08-03
公開日2005-05-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein Sci., 14, 2005
1U21
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BU of 1u21 by Molmil
transthyretin with tethered inhibitor on one monomer.
分子名称: 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin
著者Wiseman, R.L, Johnson, S.M, Kelker, M.S, Foss, T, Wilson, I.A, Kelly, J.W.
登録日2004-07-16
公開日2005-06-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Kinetic stabilization of an oligomeric protein by a single ligand binding event
J.Am.Chem.Soc., 127, 2005
1RBQ
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BU of 1rbq by Molmil
Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, PHOSPHATE ION, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
To be Published
1SQ2
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BU of 1sq2 by Molmil
Crystal Structure Analysis of the Nurse Shark New Antigen Receptor (NAR) Variable Domain in Complex With Lysozyme
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ...
著者Stanfield, R.L, Dooley, H, Flajnik, M.F, Wilson, I.A.
登録日2004-03-17
公開日2004-08-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structure of a shark single-domain antibody V region in complex with lysozyme.
Science, 305, 2004
1TCR
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BU of 1tcr by Molmil
MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Garcia, K.C, Degano, M, Stanfield, R.L, Wilson, I.A.
登録日1996-09-12
公開日1997-03-12
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.
Science, 274, 1996
5J75
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BU of 5j75 by Molmil
Fluorogen Activating Protein AM2.2 in complex with ML342
分子名称: N,4-dimethyl-N-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}benzene-1-sulfonamide, PHOSPHATE ION, scFv AM2.2
著者Stanfield, R.L, Wilson, I.A, Wu, Y.
登録日2016-04-05
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair.
J Biomol Screen, 21, 2016
1R3H
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BU of 1r3h by Molmil
Crystal Structure of T10
分子名称: Beta-2-microglobulin, MHC H2-TL-T10-129
著者Rudolph, M.G, Wilson, I.A.
登録日2003-10-02
公開日2004-03-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10.
Acta Crystallogr.,Sect.D, 60, 2004
1RBM
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BU of 1rbm by Molmil
Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
分子名称: N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID, PHOSPHATE ION, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human GAR Tfase complex structure
To be Published
1RBY
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BU of 1rby by Molmil
Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-GAR
分子名称: GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE
著者Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A.
登録日2003-11-03
公開日2005-06-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Human GAR Tfase complex structure
To be Published
1U7X
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crystal structure of a mutant M. jannashii tyrosyl-tRNA synthetase specific for O-methyl-tyrosine
分子名称: POTASSIUM ION, Tyrosyl-tRNA synthetase
著者Zhang, Y, Wang, L, Schultz, P.G, Wilson, I.A.
登録日2004-08-04
公開日2005-05-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein Sci., 14, 2005
1SJ5
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Crystal structure of a duf151 family protein (tm0160) from thermotoga maritima at 2.8 A resolution
分子名称: conserved hypothetical protein TM0160
著者Spraggon, G, Panatazatos, D, Klock, H.E, Wilson, I.A, Woods Jr, V.L, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
登録日2004-03-02
公開日2005-03-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Protein Sci., 13, 2004
1SMO
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Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .
分子名称: L(+)-TARTARIC ACID, triggering receptor expressed on myeloid cells 1
著者Kelker, M.S, Foss, T.R, Peti, W, Teyton, L, Kelly, J.W, Wilson, I.A.
登録日2004-03-09
公開日2004-09-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47A.
J.Mol.Biol., 342, 2004

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