2FSZ
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5GWI
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![BU of 5gwi by Molmil](/molmil-images/mine/5gwi) | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L. | 登録日 | 2016-09-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.737 Å) | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
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3QAA
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![BU of 3qaa by Molmil](/molmil-images/mine/3qaa) | HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A | 分子名称: | (3R,3aS,4R,6aR)-4-methoxyhexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ... | 著者 | Wang, Y.-F, Agniswamy, J, Weber, I.T. | 登録日 | 2011-01-10 | 公開日 | 2011-12-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands. ACS Med Chem Lett, 2, 2011
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5H6Y
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5JZI
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![BU of 5jzi by Molmil](/molmil-images/mine/5jzi) | Crystal structure of 1406 TCR bound to HLA-A2 with HCV 1406-1415 antigen peptide | 分子名称: | Beta-2-microglobulin, HCV1406 TCR alpha chain, HCV1406 TCR beta chain, ... | 著者 | Wang, Y, Piepenbrink, K.H, Baker, B.M. | 登録日 | 2016-05-16 | 公開日 | 2017-05-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | How an alloreactive T-cell receptor achieves peptide and MHC specificity. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3HVR
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![BU of 3hvr by Molmil](/molmil-images/mine/3hvr) | Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand with two Mg2+ at the cleavage site | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-06-16 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.211 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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5GWK
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![BU of 5gwk by Molmil](/molmil-images/mine/5gwk) | Human topoisomerase IIalpha in complex with DNA and etoposide | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | 著者 | Wang, Y.R, Wu, C.C, Chan, N.L. | 登録日 | 2016-09-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
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5K13
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5GSW
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![BU of 5gsw by Molmil](/molmil-images/mine/5gsw) | Crystal structure of EV71 3C in complex with N69S 1.8k | 分子名称: | 3C protein, ~{N}-[(2~{S})-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | 著者 | Wang, Y. | 登録日 | 2016-08-17 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor Antimicrob. Agents Chemother., 61, 2017
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5GSO
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![BU of 5gso by Molmil](/molmil-images/mine/5gso) | Crystal Structures of EV71 3C Protease in complex with NK-1.8k | 分子名称: | 3C protein, ~{N}-[(2~{S})-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | 著者 | Wang, Y. | 登録日 | 2016-08-16 | 公開日 | 2017-05-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor Antimicrob. Agents Chemother., 61, 2017
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2QD6
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![BU of 2qd6 by Molmil](/molmil-images/mine/2qd6) | HIV-1 Protease Mutant I50V with potent Antiviral inhibitor GRL-98065 | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ... | 著者 | Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T. | 登録日 | 2007-06-20 | 公開日 | 2008-04-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50, 2007
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3FBD
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3K61
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![BU of 3k61 by Molmil](/molmil-images/mine/3k61) | Crystal structure of FBF-2/fog-1 FBEa complex | 分子名称: | 5'-R(*UP*GP*UP*AP*AP*AP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2 | 著者 | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | 登録日 | 2009-10-08 | 公開日 | 2009-11-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Proc.Natl.Acad.Sci.USA, 106, 2009
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8XIR
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![BU of 8xir by Molmil](/molmil-images/mine/8xir) | Structure of pasireotide-SSTR3 G protein complex | 分子名称: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8XIO
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![BU of 8xio by Molmil](/molmil-images/mine/8xio) | Structure of L797591-SSTR1 G protein complex | 分子名称: | (2~{S})-~{N}-[(4~{S})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide, G-alpha-i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8XIQ
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![BU of 8xiq by Molmil](/molmil-images/mine/8xiq) | Structure of L796778-SSTR3 G protein complex | 分子名称: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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8XIP
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![BU of 8xip by Molmil](/molmil-images/mine/8xip) | Structure of Pasireotide-SSTR1 G protein complex | 分子名称: | 004-DTR-LYS-TY5-PHE-A1D5E, G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
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4KGB
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8HK5
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![BU of 8hk5 by Molmil](/molmil-images/mine/8hk5) | C5aR1-Gi-C5a protein complex | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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8HK3
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![BU of 8hk3 by Molmil](/molmil-images/mine/8hk3) | C3aR-Gi-apo protein complex | 分子名称: | C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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8HK2
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![BU of 8hk2 by Molmil](/molmil-images/mine/8hk2) | C3aR-Gi-C3a protein complex | 分子名称: | C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | 登録日 | 2022-11-24 | 公開日 | 2023-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
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5XIW
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![BU of 5xiw by Molmil](/molmil-images/mine/5xiw) | Crystal structure of T2R-TTL-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-04-27 | 公開日 | 2018-04-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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5XP3
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![BU of 5xp3 by Molmil](/molmil-images/mine/5xp3) | Crystal structure of apo T2R-TTL | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Wang, Y, Yang, J, Wang, T, Chen, L. | 登録日 | 2017-05-31 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
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3QGC
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![BU of 3qgc by Molmil](/molmil-images/mine/3qgc) | Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa A7U mutant | 分子名称: | 5'-R(*UP*GP*UP*GP*CP*CP*UP*UP*A)-3', Fem-3 mRNA-binding factor 2 | 著者 | Wang, Y, Qiu, C, Koh, Y.Y, Opperman, L, Gross, L, Hall, T.M.T, Wickens, M. | 登録日 | 2011-01-24 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Stacking interactions in PUF-RNA complexes. Rna, 17, 2011
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3QGB
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![BU of 3qgb by Molmil](/molmil-images/mine/3qgb) | Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa | 分子名称: | 5'-R(*UP*GP*UP*GP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2 | 著者 | Wang, Y, Qiu, C, Koh, Y.Y, Opperman, L, Gross, L, Hall, T.M.T, Wickens, M. | 登録日 | 2011-01-24 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Stacking interactions in PUF-RNA complexes. Rna, 17, 2011
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