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PDB: 133 件

6LYY
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Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.
分子名称: 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione, Basigin, Monocarboxylate transporter 1
著者Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C.
登録日2020-02-16
公開日2020-12-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
6J4O
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BU of 6j4o by Molmil
Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
分子名称: GLYCEROL, PHOSPHATE ION, Small vasohibin-binding protein, ...
著者Wang, N, Huang, H.
登録日2019-01-10
公開日2019-05-01
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 26, 2019
6J4S
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BU of 6j4s by Molmil
Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications
分子名称: GLYCEROL, PHOSPHATE ION, Small vasohibin-binding protein, ...
著者Wang, N, Bao, H, Huang, H.
登録日2019-01-10
公開日2019-05-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 26, 2019
6KBU
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BU of 6kbu by Molmil
Crystal structure of yedK
分子名称: GLYCEROL, SOS response-associated protein
著者Wang, N, Bao, H, Huang, H.
登録日2019-06-26
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6KJB
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BU of 6kjb by Molmil
wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167
分子名称: Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Wang, N, Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-06-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation.
Int J Mol Sci, 21, 2020
6KIJ
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BU of 6kij by Molmil
Crystal structure of yedK with ssDNA containing an abasic site
分子名称: DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ...
著者Wang, N, Bao, H, Huang, H.
登録日2019-07-18
公開日2019-08-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6KBZ
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BU of 6kbz by Molmil
Crystal structure of yedK with ssDNA containing a tetrahydrofuran abasic site
分子名称: 5'-D (*CP*GP*GP*TP* (3DR) P*GP*AP*TP*TP*C)-3', MAGNESIUM ION, SOS response-associated protein
著者Wang, N, Bao, H, Huang, H.
登録日2019-06-26
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.653 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6KBX
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BU of 6kbx by Molmil
Crystal structure of yedK in complex with ssDNA containing abasic site
分子名称: DNA 5'-D (*CP*GP*GP*TP* (PED)P*GP*AP*TP*TP*C)-3', SOS response-associated protein
著者Wang, N, Bao, H, Huang, H.
登録日2019-06-26
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.221 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6KBS
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BU of 6kbs by Molmil
Crystal structure of yedK in complex with ssDNA
分子名称: DNA (5'-D(*CP*GP*GP*TP*CP*GP*AP*TP*TP*C)-3'), SOS response-associated protein
著者Wang, N, Bao, H, Huang, H.
登録日2019-06-26
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6KCQ
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BU of 6kcq by Molmil
Crystal structure of yedK with ssDNA containing an abasic site
分子名称: DNA (5'-D(P*AP*AP*AP*(PED)P*AP*A)-3'), SOS response-associated protein
著者Wang, N, Bao, H, Huang, H.
登録日2019-06-28
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.
Nucleic Acids Res., 47, 2019
6A5W
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BU of 6a5w by Molmil
FXR-LBD with HNC143 and SRC1
分子名称: 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1
著者Wang, N, Liu, J.
登録日2018-06-25
公開日2018-10-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5Y
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BU of 6a5y by Molmil
Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1
分子名称: (9cis)-retinoic acid, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, ...
著者Wang, N, Liu, J.
登録日2018-06-25
公開日2018-10-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5X
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BU of 6a5x by Molmil
FXR-LBD with HNC180 and SRC1
分子名称: 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ...
著者Wang, N, Liu, J.
登録日2018-06-25
公開日2018-10-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A60
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BU of 6a60 by Molmil
Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1
分子名称: (9cis)-retinoic acid, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, Bile acid receptor, ...
著者Wang, N, Liu, J.
登録日2018-06-25
公開日2018-10-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
6A5Z
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BU of 6a5z by Molmil
Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1
分子名称: (9cis)-retinoic acid, 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, ...
著者Wang, N, Liu, J.
登録日2018-06-25
公開日2018-10-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293, 2018
7CKR
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BU of 7ckr by Molmil
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation.
分子名称: 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid, Basigin, Monocarboxylate transporter 1
著者Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C.
登録日2020-07-18
公開日2020-12-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
7CKO
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BU of 7cko by Molmil
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation
分子名称: 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid, Basigin, Monocarboxylate transporter 1
著者Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C.
登録日2020-07-18
公開日2020-12-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
7DA5
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BU of 7da5 by Molmil
Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation.
分子名称: Basigin, Monocarboxylate transporter 1
著者Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C.
登録日2020-10-14
公開日2020-12-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
6IQW
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BU of 6iqw by Molmil
Cryo-EM structure of Csm effector complex
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Csm1, Csm2, ...
著者Huo, Y, Li, T, Wang, N, Dong, Q, Wang, X, Jiang, T.
登録日2018-11-09
公開日2019-01-16
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Cryo-EM structure of Type III-A CRISPR effector complex.
Cell Res., 28, 2018
6QT9
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BU of 6qt9 by Molmil
Cryo-EM structure of SH1 full particle.
分子名称: ORF 24, ORF 25, ORF 31, ...
著者De Colibus, L, Roine, E, Walter, T.S, Ilca, S.L, Wang, X, Wang, N, Roseman, A.M, Bamford, D, Huiskonen, J.T, Stuart, D.I.
登録日2019-02-22
公開日2019-04-10
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.
Nat Commun, 10, 2019
2ZY5
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BU of 2zy5 by Molmil
R487A mutant of L-aspartate beta-decarboxylase
分子名称: L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J.
登録日2009-01-13
公開日2009-01-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase
Structure, 17, 2009
2ZY2
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BU of 2zy2 by Molmil
dodecameric L-aspartate beta-decarboxylase
分子名称: L-aspartate 4-carboxylyase, PYRIDOXAL-5'-PHOSPHATE
著者Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J.
登録日2009-01-13
公開日2009-01-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase
Structure, 17, 2009
2ZY3
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BU of 2zy3 by Molmil
dodecameric L-aspartate beta-decarboxylase
分子名称: L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J.
登録日2009-01-13
公開日2009-01-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase
Structure, 17, 2009
2ZY4
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BU of 2zy4 by Molmil
dodecameric L-aspartate beta-decarboxylase
分子名称: CHLORIDE ION, L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE
著者Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J.
登録日2009-01-13
公開日2009-01-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase
Structure, 17, 2009
6UH3
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BU of 6uh3 by Molmil
Crystal structure of bacterial heliorhodopsin 48C12
分子名称: DI(HYDROXYETHYL)ETHER, Heliorhodopsin, PALMITIC ACID, ...
著者Lu, Y, Zhou, X.E, Gao, X, Xia, R, Xu, Z, Wang, N, Leng, Y, Melcher, K, Xu, H.E, He, Y.
登録日2019-09-26
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of heliorhodopsin 48C12.
Cell Res., 30, 2020

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件を2024-06-26に公開中

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