6LYY
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![BU of 6lyy by Molmil](/molmil-images/mine/6lyy) | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation. | 分子名称: | 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione, Basigin, Monocarboxylate transporter 1 | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | 登録日 | 2020-02-16 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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6J4O
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6J4S
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![BU of 6j4s by Molmil](/molmil-images/mine/6j4s) | Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications | 分子名称: | GLYCEROL, PHOSPHATE ION, Small vasohibin-binding protein, ... | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-01-10 | 公開日 | 2019-05-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex. Nat.Struct.Mol.Biol., 26, 2019
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6KBU
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![BU of 6kbu by Molmil](/molmil-images/mine/6kbu) | Crystal structure of yedK | 分子名称: | GLYCEROL, SOS response-associated protein | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-06-26 | 公開日 | 2019-07-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
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6KJB
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![BU of 6kjb by Molmil](/molmil-images/mine/6kjb) | wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167 | 分子名称: | Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION | 著者 | Wang, N, Lei, Z, Zheng, J, Jia, Z.C. | 登録日 | 2019-07-22 | 公開日 | 2020-06-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation. Int J Mol Sci, 21, 2020
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6KIJ
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![BU of 6kij by Molmil](/molmil-images/mine/6kij) | Crystal structure of yedK with ssDNA containing an abasic site | 分子名称: | DNA (5'-D(*GP*AP*TP*TP*CP*GP*TP*CP*G)-3'), GLYCEROL, PENTANE-3,4-DIOL-5-PHOSPHATE, ... | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-07-18 | 公開日 | 2019-08-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
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6KBZ
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6KBX
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6KBS
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![BU of 6kbs by Molmil](/molmil-images/mine/6kbs) | Crystal structure of yedK in complex with ssDNA | 分子名称: | DNA (5'-D(*CP*GP*GP*TP*CP*GP*AP*TP*TP*C)-3'), SOS response-associated protein | 著者 | Wang, N, Bao, H, Huang, H. | 登録日 | 2019-06-26 | 公開日 | 2019-07-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK. Nucleic Acids Res., 47, 2019
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6KCQ
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6A5W
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![BU of 6a5w by Molmil](/molmil-images/mine/6a5w) | FXR-LBD with HNC143 and SRC1 | 分子名称: | 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1 | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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6A5Y
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![BU of 6a5y by Molmil](/molmil-images/mine/6a5y) | Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1 | 分子名称: | (9cis)-retinoic acid, 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, ... | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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6A5X
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![BU of 6a5x by Molmil](/molmil-images/mine/6a5x) | FXR-LBD with HNC180 and SRC1 | 分子名称: | 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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6A60
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![BU of 6a60 by Molmil](/molmil-images/mine/6a60) | Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 | 分子名称: | (9cis)-retinoic acid, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, Bile acid receptor, ... | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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6A5Z
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![BU of 6a5z by Molmil](/molmil-images/mine/6a5z) | Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1 | 分子名称: | (9cis)-retinoic acid, 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, ... | 著者 | Wang, N, Liu, J. | 登録日 | 2018-06-25 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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7CKR
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![BU of 7ckr by Molmil](/molmil-images/mine/7ckr) | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation. | 分子名称: | 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid, Basigin, Monocarboxylate transporter 1 | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | 登録日 | 2020-07-18 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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7CKO
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![BU of 7cko by Molmil](/molmil-images/mine/7cko) | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation | 分子名称: | 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid, Basigin, Monocarboxylate transporter 1 | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | 登録日 | 2020-07-18 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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7DA5
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![BU of 7da5 by Molmil](/molmil-images/mine/7da5) | Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation. | 分子名称: | Basigin, Monocarboxylate transporter 1 | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | 登録日 | 2020-10-14 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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6IQW
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![BU of 6iqw by Molmil](/molmil-images/mine/6iqw) | Cryo-EM structure of Csm effector complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Csm1, Csm2, ... | 著者 | Huo, Y, Li, T, Wang, N, Dong, Q, Wang, X, Jiang, T. | 登録日 | 2018-11-09 | 公開日 | 2019-01-16 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Cryo-EM structure of Type III-A CRISPR effector complex. Cell Res., 28, 2018
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6QT9
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![BU of 6qt9 by Molmil](/molmil-images/mine/6qt9) | Cryo-EM structure of SH1 full particle. | 分子名称: | ORF 24, ORF 25, ORF 31, ... | 著者 | De Colibus, L, Roine, E, Walter, T.S, Ilca, S.L, Wang, X, Wang, N, Roseman, A.M, Bamford, D, Huiskonen, J.T, Stuart, D.I. | 登録日 | 2019-02-22 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Assembly of complex viruses exemplified by a halophilic euryarchaeal virus. Nat Commun, 10, 2019
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2ZY5
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![BU of 2zy5 by Molmil](/molmil-images/mine/2zy5) | R487A mutant of L-aspartate beta-decarboxylase | 分子名称: | L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J. | 登録日 | 2009-01-13 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure, 17, 2009
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2ZY2
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![BU of 2zy2 by Molmil](/molmil-images/mine/2zy2) | dodecameric L-aspartate beta-decarboxylase | 分子名称: | L-aspartate 4-carboxylyase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J. | 登録日 | 2009-01-13 | 公開日 | 2009-01-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure, 17, 2009
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2ZY3
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![BU of 2zy3 by Molmil](/molmil-images/mine/2zy3) | dodecameric L-aspartate beta-decarboxylase | 分子名称: | L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J. | 登録日 | 2009-01-13 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure, 17, 2009
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2ZY4
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![BU of 2zy4 by Molmil](/molmil-images/mine/2zy4) | dodecameric L-aspartate beta-decarboxylase | 分子名称: | CHLORIDE ION, L-aspartate beta-decarboxylase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chen, H.-J, Ko, T.-P, Lee, C.-Y, Wang, N.-C, Wang, A.H.-J. | 登録日 | 2009-01-13 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure, 17, 2009
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6UH3
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![BU of 6uh3 by Molmil](/molmil-images/mine/6uh3) | Crystal structure of bacterial heliorhodopsin 48C12 | 分子名称: | DI(HYDROXYETHYL)ETHER, Heliorhodopsin, PALMITIC ACID, ... | 著者 | Lu, Y, Zhou, X.E, Gao, X, Xia, R, Xu, Z, Wang, N, Leng, Y, Melcher, K, Xu, H.E, He, Y. | 登録日 | 2019-09-26 | 公開日 | 2019-12-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of heliorhodopsin 48C12. Cell Res., 30, 2020
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