6A5Y

Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1

Summary for 6A5Y

DescriptorBile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... (8 entities in total)
Functional Keywordsnuclear receptor, heterodimer, complex, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight58362.85
Authors
Wang, N.,Liu, J. (deposition date: 2018-06-25, release date: 2018-10-10, Last modification date: 2018-10-17)
Primary citation
Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.
Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting co-activator binding.
J. Biol. Chem., 2018
PubMed: 30275017 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.004652
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2472 0.4% 4.6% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6a5y
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Molmil generated image of 6a5y
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