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6A5Y

Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
D0003677molecular_functionDNA binding
D0003707molecular_functionnuclear steroid receptor activity
D0005634cellular_componentnucleus
D0006355biological_processregulation of DNA-templated transcription
D0008270molecular_functionzinc ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue 9R0 A 501
ChainResidue
AMET265
AILE335
APRO341
AHIS344
ALEU348
ATYR369
AHIS447
ATRP454
AHOH608
AHOH615
ATHR270
AILE273
ALEU287
ATHR288
AALA291
AMET328
APHE329
ASER332

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 502
ChainResidue
AARG264
APRO266
AGLN267

site_idAC3
Number of Residues11
Detailsbinding site for residue 9CR D 501
ChainResidue
DILE268
DALA271
DGLN275
DTRP305
DPHE313
DARG316
DLEU326
DALA327
DILE345
DCYS432
DHOH615

site_idAC4
Number of Residues5
Detailsbinding site for residue PO4 D 502
ChainResidue
DGLN411
DPRO412
DGLY413
DARG414
DLYS417

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 D 503
ChainResidue
AASN444
DARG348
DSER427
DHOH601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER757
FSER641
ATYR369
AHIS447

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
ChainResidueDetails
ATHR442

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
ChainResidueDetails
ALYS275

218500

PDB entries from 2024-04-17

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