6A5Y
Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue 9R0 A 501 |
| Chain | Residue |
| A | MET265 |
| A | ILE335 |
| A | PRO341 |
| A | HIS344 |
| A | LEU348 |
| A | TYR369 |
| A | HIS447 |
| A | TRP454 |
| A | HOH608 |
| A | HOH615 |
| A | THR270 |
| A | ILE273 |
| A | LEU287 |
| A | THR288 |
| A | ALA291 |
| A | MET328 |
| A | PHE329 |
| A | SER332 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ARG264 |
| A | PRO266 |
| A | GLN267 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 9CR D 501 |
| Chain | Residue |
| D | ILE268 |
| D | ALA271 |
| D | GLN275 |
| D | TRP305 |
| D | PHE313 |
| D | ARG316 |
| D | LEU326 |
| D | ALA327 |
| D | ILE345 |
| D | CYS432 |
| D | HOH615 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 502 |
| Chain | Residue |
| D | GLN411 |
| D | PRO412 |
| D | GLY413 |
| D | ARG414 |
| D | LYS417 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 503 |
| Chain | Residue |
| A | ASN444 |
| D | ARG348 |
| D | SER427 |
| D | HOH601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
