8UMU
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![BU of 8umu by Molmil](/molmil-images/mine/8umu) | Atomic model of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMW
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![BU of 8umw by Molmil](/molmil-images/mine/8umw) | Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex in the five-subunit binding state (state 4) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMV
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![BU of 8umv by Molmil](/molmil-images/mine/8umv) | Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with narrow PCNA opening state I (state 5) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UII
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![BU of 8uii by Molmil](/molmil-images/mine/8uii) | |
2HKC
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![BU of 2hkc by Molmil](/molmil-images/mine/2hkc) | NMR Structure of the IQ-modified Dodecamer CTCGGC[IQ]GCCATC | Descriptor: | 3-METHYL-3H-IMIDAZO[4,5-F]QUINOLIN-2-AMINE, 5'-D(*CP*TP*CP*GP*GP*CP*GP*CP*CP*AP*TP*C)-3', 5'-D(*GP*AP*TP*GP*GP*CP*GP*CP*CP*GP*AP*G)-3' | Authors: | Wang, F, DeMuro, N.E, Elmquist, C.E, Stover, J.S, Rizzo, C.J, Stone, M.P. | Deposit date: | 2006-07-03 | Release date: | 2006-10-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions. J.Am.Chem.Soc., 128, 2006
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8XPN
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![BU of 8xpn by Molmil](/molmil-images/mine/8xpn) | The Crystal Structure of USP8 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ubiquitin carboxyl-terminal hydrolase 8, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wang, J. | Deposit date: | 2024-01-04 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of USP8 from Biortus. To Be Published
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8WGQ
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![BU of 8wgq by Molmil](/molmil-images/mine/8wgq) | The Crystal Structure of L-asparaginase from Biortus. | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, L-asparaginase | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | Deposit date: | 2023-09-22 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Crystal Structure of L-asparaginase from Biortus. To Be Published
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8YGZ
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![BU of 8ygz by Molmil](/molmil-images/mine/8ygz) | The Crystal Structure of TGF beta R2 kinase domain from Biortus. | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, TGF-beta receptor type-2 | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | Deposit date: | 2024-02-27 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of TGF beta R2 kinase domain from Biortus. To Be Published
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8X70
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![BU of 8x70 by Molmil](/molmil-images/mine/8x70) | The Crystal Structure of IFI16 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, Gamma-interferon-inducible protein 16, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Wang, J. | Deposit date: | 2023-11-22 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of IFI16 from Biortus. To Be Published
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6EF8
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![BU of 6ef8 by Molmil](/molmil-images/mine/6ef8) | Cryo-EM of the OmcS nanowires from Geobacter sulfurreducens | Descriptor: | C-type cytochrome OmcS, HEME C | Authors: | Wang, F, Gu, Y, Egelman, E.H, Malvankar, N.S. | Deposit date: | 2018-08-16 | Release date: | 2019-04-10 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers. Cell, 177, 2019
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6UHY
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![BU of 6uhy by Molmil](/molmil-images/mine/6uhy) | WDR5 in complex with Myc site fragment inhibitor | Descriptor: | 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 | Authors: | Wang, F, Fesik, S.W. | Deposit date: | 2019-09-29 | Release date: | 2020-04-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
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6UHZ
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![BU of 6uhz by Molmil](/molmil-images/mine/6uhz) | WDR5 in complex with Myc site fragment inhibitor | Descriptor: | 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 | Authors: | Wang, F, Fesik, S.w. | Deposit date: | 2019-09-29 | Release date: | 2020-04-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.258 Å) | Cite: | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
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8UNJ
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![BU of 8unj by Molmil](/molmil-images/mine/8unj) | Atomic model of the human CTF18-RFC alone in the apo state (State 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-19 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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3NBH
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![BU of 3nbh by Molmil](/molmil-images/mine/3nbh) | Crystal structure of human RMI1C-RMI2 complex | Descriptor: | RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | Authors: | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | Deposit date: | 2010-06-03 | Release date: | 2010-09-22 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex. Structure, 18, 2010
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8D9M
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![BU of 8d9m by Molmil](/molmil-images/mine/8d9m) | Cryo-EM of the OmcZ nanowires from Geobacter sulfurreducens | Descriptor: | Cytochrome c, HEME C | Authors: | Wang, F, Chan, C.H, Mustafa, K, Hochbaum, A.I, Bond, D.R, Egelman, E.H. | Deposit date: | 2022-06-10 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times. Elife, 11, 2022
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8D4X
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![BU of 8d4x by Molmil](/molmil-images/mine/8d4x) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-06-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8E0Q
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![BU of 8e0q by Molmil](/molmil-images/mine/8e0q) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-08-09 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8EWI
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![BU of 8ewi by Molmil](/molmil-images/mine/8ewi) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-10-23 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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6D5F
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![BU of 6d5f by Molmil](/molmil-images/mine/6d5f) | Cryo-EM reconstruction of membrane-enveloped filamentous virus SFV1 (Sulfolobus filamentous virus 1) | Descriptor: | DNA (336-MER), Fimbrial protein | Authors: | Wang, F, Osinski, T, Liu, Y, Krupovic, M, Prangishvili, D, Egelman, E.H. | Deposit date: | 2018-04-19 | Release date: | 2018-08-29 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile. Nat Commun, 9, 2018
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5JR3
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![BU of 5jr3 by Molmil](/molmil-images/mine/5jr3) | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone | Descriptor: | 7-hydroxy-4-methyl-2H-chromen-2-one, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Wang, F, Johnson, B.R, Huber, T.D, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2016-05-05 | Release date: | 2016-06-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published) To Be Published
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8FK7
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![BU of 8fk7 by Molmil](/molmil-images/mine/8fk7) | Structure of the Pyrobaculum calidifontis flagellar-like archaeal type IV pilus | Descriptor: | Flagellin | Authors: | Wang, F, Kreutzberger, M.A, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | Deposit date: | 2022-12-20 | Release date: | 2023-06-28 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | The evolution of archaeal flagellar filaments. Proc.Natl.Acad.Sci.USA, 120, 2023
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6VY1
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![BU of 6vy1 by Molmil](/molmil-images/mine/6vy1) | Cryo-EM structure of filamentous PFD from Methanocaldococcus jannaschii | Descriptor: | Prefoldin subunit alpha 2 | Authors: | Wang, F, Chen, Y.X, Ing, N.L, Hochbaum, A.I, Clark, D.S, Glover, D.J, Egelman, E.H. | Deposit date: | 2020-02-25 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires. Acs Nano, 14, 2020
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2HKB
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![BU of 2hkb by Molmil](/molmil-images/mine/2hkb) | NMR Structure of the B-DNA Dodecamer CTCGGCGCCATC | Descriptor: | 5'-D(*CP*TP*CP*GP*GP*CP*GP*CP*CP*AP*TP*C)-3', 5'-D(*GP*AP*TP*GP*GP*CP*GP*CP*CP*GP*AP*G)-3' | Authors: | Wang, F, DeMuro, N.E, Elmquist, C.E, Stover, J.S, Rizzo, C.J, Stone, M.P. | Deposit date: | 2006-07-03 | Release date: | 2006-10-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions. J.Am.Chem.Soc., 128, 2006
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8GZB
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![BU of 8gzb by Molmil](/molmil-images/mine/8gzb) | SARS-CoV-2 3CLpro | Descriptor: | 1,2-ETHANEDIOL, 2-(4-chlorophenyl)-1,3,4-oxadiazole, 3C-like proteinase nsp5 | Authors: | Wang, F, Cen, Y.X, Tian, P. | Deposit date: | 2022-09-26 | Release date: | 2023-09-27 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Nature-inspired catalytic asymmetric rearrangement of cyclopropylcarbinyl cation. Sci Adv, 9, 2023
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4ZAS
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![BU of 4zas by Molmil](/molmil-images/mine/4zas) | Crystal structure of sugar aminotransferase CalS13 from Micromonospora echinospora | Descriptor: | CalS13, SULFATE ION, THYMIDINE-5'-DIPHOSPHATE, ... | Authors: | Wang, F, Singh, S, Miller, M.D, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-04-13 | Release date: | 2015-04-29 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Structure characterization of sugar aminotransferases CalS13 and WecE provides the basis for a unifying structural model for stereochemical outcome. To Be Published
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