4EZB
 
 | | CRYSTAL STRUCTURE OF the Conserved hypothetical protein from Sinorhizobium meliloti 1021 | | Descriptor: | uncharacterized conserved protein | | Authors: | Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Zenchek, W, Love, J, Fiser, A, Khafizov, K, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2012-05-02 | | Release date: | 2012-05-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | CRYSTAL STRUCTURE OF the Conserved hypothetical protein from Sinorhizobium meliloti 1021
To be Published
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6M73
 | | Crystal structure of Enterococcus hirae L-lactate oxidase in complex with D-lactate form ligand | | Descriptor: | 1,2-ETHANEDIOL, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Yoshida, H, Hiraka, K, Tsugawa, W, Sode, K. | | Deposit date: | 2020-03-16 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of lactate oxidase from Enterococcus hirae revealed new aspects of active site loop function: Product-inhibition mechanism and oxygen gatekeeper
Protein Sci., 31, 2022
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6M74
 | | Crystal structure of Enterococcus hirae L-lactate oxidase M207L in complex with D-lactate form ligand | | Descriptor: | 1,2-ETHANEDIOL, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Yoshida, H, Hiraka, K, Tsugawa, W, Sode, K. | | Deposit date: | 2020-03-16 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Structure of lactate oxidase from Enterococcus hirae revealed new aspects of active site loop function: Product-inhibition mechanism and oxygen gatekeeper
Protein Sci., 31, 2022
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1SXI
 | | Structure of apo transcription regulator B. megaterium | | Descriptor: | Glucose-resistance amylase regulator, MAGNESIUM ION | | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | | Deposit date: | 2004-03-30 | | Release date: | 2004-10-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural studies on the apo transcription factor form B. megaterium
Cell(Cambridge,Mass.), 118, 2004
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1E2A
 | | ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS | | Descriptor: | ENZYME IIA, MAGNESIUM ION | | Authors: | Sliz, P, Engelmann, R, Hengstenberg, W, Pai, E.F. | | Deposit date: | 1997-04-25 | | Release date: | 1998-04-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system.
Structure, 5, 1997
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4F4N
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1XD5
 | | Crystal structures of novel monomeric monocot mannose-binding lectins from Gastrodia elata | | Descriptor: | SULFATE ION, antifungal protein GAFP-1 | | Authors: | Liu, W, Yang, N, Wang, M, Huang, R.H, Hu, Z, Wang, D.C. | | Deposit date: | 2004-09-04 | | Release date: | 2005-01-11 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Mechanism Governing the Quaternary Organization of Monocot Mannose-binding Lectin Revealed by the Novel Monomeric Structure of an Orchid Lectin
J.Biol.Chem., 280, 2005
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5Y9J
 | | BAFF in complex with belimumab | | Descriptor: | Tumor necrosis factor ligand superfamily member 13B, belibumab light chain, belimumab heavy chain | | Authors: | Heo, Y.-S, Shin, W. | | Deposit date: | 2017-08-25 | | Release date: | 2018-02-21 | | Last modified: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus.
Nat Commun, 9, 2018
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1XBO
 | | PTP1B complexed with Isoxazole Carboxylic Acid | | Descriptor: | 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | | Authors: | Zhao, H, Liu, G, Xin, Z, Serby, M, Pei, Z, Szczepankiewicz, B.G, Hajduk, P.J, Abad-Zapatero, C, Hutchins, C.W, Lubben, T.H, Ballaron, S.J, Hassach, D.L, Kaszubska, W, Rondinone, C.M, Trevillyan, J.M, Jirousek, M.R. | | Deposit date: | 2004-08-31 | | Release date: | 2004-10-19 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
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6LZP
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2M3V
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1TV0
 | | Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells | | Descriptor: | Cryptdin-4 | | Authors: | Jing, W, Hunter, H.N, Tanabe, H, Ouellette, A.J, Vogel, H.J. | | Deposit date: | 2004-06-25 | | Release date: | 2005-01-04 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of Cryptdin-4, a Mouse Paneth Cell alpha-Defensin.
Biochemistry, 43, 2004
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4F7W
 | | Crystal structure of Klebsiella pneumoniae pantothenate kinase in complex with N-pentylpantothenamide | | Descriptor: | (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide, ADENOSINE-5'-DIPHOSPHATE, Pantothenate kinase, ... | | Authors: | Li, B, Tempel, W, Smil, D, Bolshan, Y, Hong, B.S, Park, H.W, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-05-16 | | Release date: | 2013-04-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Proteins, 81, 2013
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1XDW
 | | NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans | | Descriptor: | NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase | | Authors: | Martins, B.M, Macedo-Ribeiro, S, Bresser, J, Buckel, W, Messerschmidt, A. | | Deposit date: | 2004-09-08 | | Release date: | 2005-03-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans.
Febs J., 272, 2005
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5YEU
 | | Structural and mechanistic analyses reveal a unique Cas4-like protein in the mimivirus virophage resistance element system | | Descriptor: | MAGNESIUM ION, Uncharacterized protein R354 | | Authors: | Dou, C, Yu, M.J, Gu, Y.J, Cheng, W. | | Deposit date: | 2017-09-19 | | Release date: | 2018-07-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.001 Å) | | Cite: | Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System.
Iscience, 3, 2018
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5YF8
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1TXC
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1U3B
 | | Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains | | Descriptor: | amyloid beta A4 precursor protein-binding, family A, member 1 | | Authors: | Feng, W, Long, J.-F, Chan, L.-N, He, C, Fu, A, Xia, J, Ip, N.Y, Zhang, M. | | Deposit date: | 2004-07-21 | | Release date: | 2005-07-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nat.Struct.Mol.Biol., 12, 2005
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6MKS
 | | Cryo-EM structure of NLRC4-CARD filament | | Descriptor: | Chimera protein of NLR family CARD domain-containing protein 4 and EGFP | | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | | Deposit date: | 2018-09-26 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly.
J. Biol. Chem., 293, 2018
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4FLA
 | | Crystal structure of human RPRD1B, carboxy-terminal domain | | Descriptor: | Regulation of nuclear pre-mRNA domain-containing protein 1B, UNKNOWN ATOM OR ION | | Authors: | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Guo, X, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-06-14 | | Release date: | 2012-08-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
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1XBF
 | | X-RAY STRUCTURE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CAR10 FROM C. ACETOBUTYLICUM | | Descriptor: | Clostridium acetobutylicum Q97KL0, SULFATE ION | | Authors: | Kuzin, A.P, Chen, Y, Vorobiev, S, Yong, W, Acton, T, Ho, C.-K, Conover, K, Cooper, B, Ciano, M, Xiao, R, Montelione, G, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2004-08-30 | | Release date: | 2004-09-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-RAY STRUCTURE NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CAR10 FROM C. ACETOBUTYLICUM
To be published
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2MBK
 | | The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed | | Descriptor: | Crossveinless 2 | | Authors: | Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W. | | Deposit date: | 2013-08-02 | | Release date: | 2013-10-16 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed.
Molecules, 18, 2013
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1U1G
 | | Structure of E. coli uridine phosphorylase complexed to 5-(m-(benzyloxy)benzyl)barbituric acid (BBBA) | | Descriptor: | 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)-6-HYDROXYPYRIMIDINE-2,4(1H,3H)-DIONE, POTASSIUM ION, Uridine phosphorylase | | Authors: | Bu, W, Settembre, E.C, Ealick, S.E. | | Deposit date: | 2004-07-15 | | Release date: | 2005-07-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta Crystallogr.,Sect.D, 61, 2005
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1XDT
 | | COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR | | Descriptor: | DIPHTHERIA TOXIN, HEPARIN-BINDING EPIDERMAL GROWTH FACTOR | | Authors: | Louie, G.V, Yang, W, Bowman, M.E, Choe, S. | | Deposit date: | 1997-11-18 | | Release date: | 1998-02-25 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.
Mol.Cell, 1, 1997
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6AYC
 | | Naegleria fowleri CYP51-itraconazole complex | | Descriptor: | 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE, Protein CYP51 | | Authors: | Debnath, A, Calvet, C.M, Jennings, G, Zhou, W, Aksenov, A, Luth, M, Abagyan, R, Nes, W.D, McKerrow, J.H, Podust, L.M. | | Deposit date: | 2017-09-08 | | Release date: | 2017-11-22 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
PLoS Negl Trop Dis, 11, 2017
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