6NUU
 
 | | Structure of Calcineurin mutant in complex with NHE1 peptide | | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Wang, X, Page, R, Peti, W. | | Deposit date: | 2019-02-02 | | Release date: | 2019-07-03 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin.
Nat Commun, 10, 2019
|
|
2ODD
 | | Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor | | Descriptor: | Protein CBFA2T1, SMRT, ZINC ION | | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | | Deposit date: | 2006-12-22 | | Release date: | 2007-06-19 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
|
|
1YFD
 | | Crystal structure of the Y122H mutant of ribonucleotide reductase R2 protein from E. coli | | Descriptor: | MERCURY (II) ION, MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 beta chain | | Authors: | Kolberg, M, Logan, D.T, Bleifuss, G, Poetsch, S, Sjoeberg, B.M, Graeslund, A, Lubitz, W, Lassmann, G, Lendzian, F. | | Deposit date: | 2004-12-31 | | Release date: | 2005-02-15 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies
J.Biol.Chem., 280, 2005
|
|
6NVW
 | | Crystal structure of penicillin G acylase from Bacillus megaterium | | Descriptor: | CALCIUM ION, Penicillin G acylase | | Authors: | Blankenfeldt, W. | | Deposit date: | 2019-02-05 | | Release date: | 2019-07-03 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.203 Å) | | Cite: | Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability.
Appl.Microbiol.Biotechnol., 103, 2019
|
|
6O2L
 | |
6NIF
 | | crystal structure of human REV7-RAN complex | | Descriptor: | hREV7, GTP-binding nuclear protein Ran, hREV3 fusion | | Authors: | Wang, X, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W. | | Deposit date: | 2018-12-27 | | Release date: | 2019-09-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch.
J.Biol.Chem., 294, 2019
|
|
2NS7
 | | How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor | | Descriptor: | Tetracycline repressor protein | | Authors: | Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A. | | Deposit date: | 2006-11-03 | | Release date: | 2007-07-24 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
J.Mol.Biol., 368, 2007
|
|
1YEM
 | | Conserved hypothetical protein Pfu-838710-001 from Pyrococcus furiosus | | Descriptor: | Conserved hypothetical protein Pfu-838710-001, PLATINUM (II) ION, UNKNOWN ATOM OR ION | | Authors: | Yang, H, Chang, J, Shah, A, Ng, J.D, Liu, Z.-J, Chen, L, Lee, D, Tempel, W, Praissman, J.L, Lin, D, Arendall III, W.B, Richardson, J.S, Richardson, D.C, Jenney Jr, F.E, Adams, M.W.W, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-12-28 | | Release date: | 2005-01-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Conserved hypothetical protein Pfu-838710-001 from Pyrococcus furiosus
To be published
|
|
1FLG
 | | CRYSTAL STRUCTURE OF THE QUINOPROTEIN ETHANOL DEHYDROGENASE FROM PSEUDOMONAS AERUGINOSA | | Descriptor: | CALCIUM ION, PROTEIN (QUINOPROTEIN ETHANOL DEHYDROGENASE), PYRROLOQUINOLINE QUINONE | | Authors: | Keitel, T, Diehl, A, Knaute, T, Stezowski, J.J, Hohne, W, Gorisch, H. | | Deposit date: | 2000-08-14 | | Release date: | 2000-08-30 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | X-ray structure of the quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: basis of substrate specificity.
J.Mol.Biol., 297, 2000
|
|
1YDL
 | | Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045. | | Descriptor: | general transcription factor IIH, polypeptide 5 | | Authors: | Forouhar, F, Edstrom, W, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2004-12-24 | | Release date: | 2005-02-08 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045.
To be Published
|
|
1FO7
 | | HUMAN PRION PROTEIN MUTANT E200K FRAGMENT 90-231 | | Descriptor: | PRION PROTEIN | | Authors: | Zhang, Y, Swietnicki, W, Zagorski, M.G, Surewicz, W.K, Soennichsen, F.D. | | Deposit date: | 2000-08-25 | | Release date: | 2000-09-21 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases.
J.Biol.Chem., 275, 2000
|
|
6NQ1
 | | Cryo-EM structure of human TPC2 channel in the apo state | | Descriptor: | Two pore calcium channel protein 2 | | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | Deposit date: | 2019-01-18 | | Release date: | 2019-03-27 | | Last modified: | 2019-11-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
|
|
6NRB
 | | hTRiC-hPFD Class2 | | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | | Deposit date: | 2019-01-23 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Cell, 177, 2019
|
|
5XJX
 | | Pre-formed plant receptor ERL1-TMM complex | | Descriptor: | LRR receptor-like serine/threonine-protein kinase ERL1, Protein TOO MANY MOUTHS | | Authors: | Chai, J, Lin, G, Zhang, L, Han, Z, Yang, X, Liu, W, Qi, Y, Chang, J, Li, E. | | Deposit date: | 2017-05-04 | | Release date: | 2019-01-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.055 Å) | | Cite: | A receptor-like protein acts as a specificity switch for the regulation of stomatal development.
Genes Dev., 31, 2017
|
|
6NUD
 | | Small conformation of ssRNA-bound CRISPR_Csm complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms protein Csm2, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | | Authors: | Zhang, K, Pintilie, G, Li, S, Zhu, Y, Chiu, W, Huang, Z. | | Deposit date: | 2019-01-31 | | Release date: | 2019-03-13 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019
|
|
6BL0
 | | Novel Modes of Inhibition of Wild-Type IDH1:Direct Covalent Modification of His315 with Cmpd11 | | Descriptor: | (5aS,6S,8S,9aS)-2-(benzenecarbonyl)-6-methyl-7-oxo-9a-phenyl-4,5,5a,6,7,8,9,9a-octahydro-2H-benzo[g]indazole-8-carbonitrile, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | | Authors: | Jakob, C.G, Qiu, W. | | Deposit date: | 2017-11-09 | | Release date: | 2018-07-25 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J. Med. Chem., 61, 2018
|
|
1Y3I
 | | Crystal Structure of Mycobacterium tuberculosis NAD kinase-NAD complex | | Descriptor: | GLYCEROL, Inorganic polyphosphate/ATP-NAD kinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Mori, S, Yamasaki, M, Maruyama, Y, Momma, K, Kawai, S, Hashimoto, W, Mikami, B, Murata, K. | | Deposit date: | 2004-11-25 | | Release date: | 2005-01-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex
Biochem.Biophys.Res.Commun., 327, 2005
|
|
4GLM
 | | Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens] | | Descriptor: | Dynamin-binding protein, UNKNOWN ATOM OR ION | | Authors: | Dong, A, Guan, X, Huang, H, Tempel, W, Gu, J, Sidhu, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-08-14 | | Release date: | 2012-11-21 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens]
to be published
|
|
6BMG
 | | Structure of Recombinant Dwarf Sperm Whale Myoglobin (Oxy) | | Descriptor: | ACETATE ION, CADMIUM ION, Myoglobin, ... | | Authors: | Samuel, P.P, Miller, M.D, Xu, W, Alvarado, S, Phillips Jr, G.N, Olson, J.S. | | Deposit date: | 2017-11-14 | | Release date: | 2017-11-29 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Structure of Recombinant Dwarf Sperm Whale Myoglobin (Oxy)
To Be Published
|
|
5XTN
 | |
4GO6
 | | Crystal structure of HCF-1 self-association sequence 1 | | Descriptor: | HCF C-terminal chain 1, HCF N-terminal chain 1, SULFATE ION | | Authors: | Park, J, Lammers, F, Herr, W, Song, J. | | Deposit date: | 2012-08-18 | | Release date: | 2012-10-17 | | Last modified: | 2013-07-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
2OQK
 | | Crystal structure of putative Cryptosporidium parvum translation initiation factor eIF-1A | | Descriptor: | Putative translation initiation factor eIF-1A, SULFATE ION | | Authors: | Dong, A, Lew, J, Zhao, Y, Hassanali, A, Lin, L, Qiu, W, Brokx, S.J, Wasney, G, Vedadi, M, Kozieradzki, I, Bochkarev, A, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Hui, R, Altamentova, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-01-31 | | Release date: | 2007-02-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of putative Cryptosporidium parvum translation initiation factor eIF-1A
To be Published
|
|
6NQM
 | | Crystal structure of Human LSD1 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A | | Authors: | Tan, A.H.Y, Tu, W, McCuaig, R, Donovan, T, Tsimbalyuk, S, Forwood, J.K, Rao, S. | | Deposit date: | 2019-01-21 | | Release date: | 2019-02-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Front Immunol, 10, 2019
|
|
6BHI
 | | Crystal structure of SETDB1 with a modified H3 peptide | | Descriptor: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION | | Authors: | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-10-30 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
|
|
5X4P
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 6 | | Descriptor: | 5-[(5-chloranylpyrimidin-4-yl)amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein | | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | | Deposit date: | 2017-02-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
J. Med. Chem., 60, 2017
|
|
