8X5M
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![BU of 8x5m by Molmil](/molmil-images/mine/8x5m) | The Crystal Structure of JNK1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide, GLYCEROL, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | Deposit date: | 2023-11-17 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of JNK1 from Biortus. To Be Published
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8X72
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![BU of 8x72 by Molmil](/molmil-images/mine/8x72) | The Crystal Structure of PLK1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. | Deposit date: | 2023-11-22 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Crystal Structure of PLK1 from Biortus. To Be Published
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9AUN
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![BU of 9aun by Molmil](/molmil-images/mine/9aun) | Structure of SARS-CoV-2 Mpro mutant (T21I,T304I) | Descriptor: | 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8W1O
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![BU of 8w1o by Molmil](/molmil-images/mine/8w1o) | Cryo-EM structure of BTV virion | Descriptor: | Core protein VP3, Outer capsid protein VP2, RNA-1, ... | Authors: | Xia, X, Sung, P.Y, Martynowycz, M.W, Gonen, T, Roy, P, Zhou, Z.H. | Deposit date: | 2024-02-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell, 187, 2024
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8VL9
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![BU of 8vl9 by Molmil](/molmil-images/mine/8vl9) | Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue | Descriptor: | CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... | Authors: | Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. | Deposit date: | 2024-01-11 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
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8VAF
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![BU of 8vaf by Molmil](/molmil-images/mine/8vaf) | Cryogenic electron microscopy structure of apo human serum albumin | Descriptor: | Serum albumin | Authors: | Catalano, C, Lucier, K.W, To, D, Senko, S, Tran, N.L, Farwell, A.C, Silva, S.M, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2023-12-11 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The CryoEM structure of human serum albumin in complex with ligands. J.Struct.Biol., 216, 2024
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8XB9
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![BU of 8xb9 by Molmil](/molmil-images/mine/8xb9) | The Crystal Structure of polo-box domain of PLK1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase PLK1 | Authors: | Wang, F, Cheng, W, Yuan, Z, Meng, Q, Zhang, B. | Deposit date: | 2023-12-06 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Crystal Structure of polo-box domain of PLK1 from Biortus To Be Published
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8WSS
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![BU of 8wss by Molmil](/molmil-images/mine/8wss) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | Deposit date: | 2023-10-17 | Release date: | 2024-06-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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9F9M
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![BU of 9f9m by Molmil](/molmil-images/mine/9f9m) | Crystal structure of MUS81-EME1 bound by compound 21. | Descriptor: | 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ... | Authors: | Collie, G.W. | Deposit date: | 2024-05-08 | Release date: | 2024-06-19 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.469 Å) | Cite: | Fragment-Based Discovery of Novel MUS81 Inhibitors. Acs Med.Chem.Lett., 15, 2024
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8X5K
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![BU of 8x5k by Molmil](/molmil-images/mine/8x5k) | The Crystal Structure of SYK from Biortus. | Descriptor: | 1,2-ETHANEDIOL, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide, Tyrosine-protein kinase SYK | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. | Deposit date: | 2023-11-17 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of SYK from Biortus. To Be Published
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5JQW
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![BU of 5jqw by Molmil](/molmil-images/mine/5jqw) | The crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit of Francisella tularensis subsp. tularensis SCHU S4 in complex with ADP | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, N5-carboxyaminoimidazole ribonucleotide synthase | Authors: | Tan, K, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2016-05-05 | Release date: | 2016-05-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | The crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit of Francisella tularensis subsp. tularensis SCHU S4 in complex with ADP To Be Published
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8WOI
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![BU of 8woi by Molmil](/molmil-images/mine/8woi) | |
9FFH
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![BU of 9ffh by Molmil](/molmil-images/mine/9ffh) | Native capsid of Rhodobacter microvirus Ebor computed with I4 symmetry | Descriptor: | Major capsid protein | Authors: | Bardy, P, MacDonald, C.I.W, Jenkins, H.T, Chechik, M, Hart, S.J, Turkenburg, J.P, Blaza, J.N, Fogg, P.C.M, Antson, A.A. | Deposit date: | 2024-05-23 | Release date: | 2024-06-12 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A stargate mechanism of Microviridae genome delivery unveiled by cryogenic electron tomography. Biorxiv, 2024
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8XBI
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![BU of 8xbi by Molmil](/molmil-images/mine/8xbi) | Human GPR34 -Gi complex bound to M1, receptor focused | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Probable G-protein coupled receptor 34 | Authors: | Kawahara, R, Shihoya, W, Nureki, O. | Deposit date: | 2023-12-06 | Release date: | 2023-12-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
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9B93
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![BU of 9b93 by Molmil](/molmil-images/mine/9b93) | |
8YHF
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![BU of 8yhf by Molmil](/molmil-images/mine/8yhf) | The Crystal Structure of the Type I TGF beta receptor from Biortus. | Descriptor: | 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, TGF-beta receptor type-1 | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The Crystal Structure of the Type I TGF beta receptor from Biortus. To Be Published
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8XJ7
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![BU of 8xj7 by Molmil](/molmil-images/mine/8xj7) | The Cryo-EM structure of MPXV E5 in complex with DNA | Descriptor: | DNA (70-MER), MAGNESIUM ION, Monkeypox virus E5, ... | Authors: | Zhang, W, Liu, Y, Gao, H, Gan, J. | Deposit date: | 2023-12-20 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural and functional insights into the helicase protein E5 of Mpox virus. Cell Discov, 10, 2024
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8WKZ
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![BU of 8wkz by Molmil](/molmil-images/mine/8wkz) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31 | Descriptor: | CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ... | Authors: | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | Deposit date: | 2023-09-28 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67, 2024
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9B3R
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![BU of 9b3r by Molmil](/molmil-images/mine/9b3r) | The structure of human cardiac F-actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Sousa, D, Rynkiewicz, M.J, Lehman, W, Cammarato, A. | Deposit date: | 2024-03-20 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of human cardiac actin To Be Published
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9G7H
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![BU of 9g7h by Molmil](/molmil-images/mine/9g7h) | Human Sirt6 in complex with ADP-ribose and the inhibitor 2-Pr | Descriptor: | 2,4-bis(oxidanylidene)-1-[2-oxidanylidene-2-[[(2S)-3-oxidanylidene-3-(propylamino)-2-[3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)propanoylamino]propyl]amino]ethyl]pyrimidine-5-carboxamide, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ... | Authors: | You, W, Steegborn, C. | Deposit date: | 2024-07-21 | Release date: | 2024-08-14 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. Chemmedchem, 2024
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8YHH
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![BU of 8yhh by Molmil](/molmil-images/mine/8yhh) | The Crystal Structure of Mitotic Kinesin Eg5 from Biortus | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Wu, B. | Deposit date: | 2024-02-28 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Crystal Structure of Mitotic Kinesin Eg5 from Biortus To Be Published
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9BB5
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![BU of 9bb5 by Molmil](/molmil-images/mine/9bb5) | |
9AUL
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![BU of 9aul by Molmil](/molmil-images/mine/9aul) | Structure of SARS-CoV-2 Mpro mutant (A173V,T304I)) in complex with Nirmatrelvir (PF-07321332) | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8WST
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![BU of 8wst by Molmil](/molmil-images/mine/8wst) | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ... | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | Deposit date: | 2023-10-17 | Release date: | 2024-06-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discov, 10, 2024
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9BB7
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![BU of 9bb7 by Molmil](/molmil-images/mine/9bb7) | |