3HDH
| PIG HEART SHORT CHAIN L-3-HYDROXYACYL COA DEHYDROGENASE REVISITED: SEQUENCE ANALYSIS AND CRYSTAL STRUCTURE DETERMINATION | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (L-3-HYDROXYACYL COA DEHYDROGENASE) | 著者 | Barycki, J.J, O'Brien, L.K, Birktoft, J.J, Strauss, A.W, Banaszak, L.J. | 登録日 | 1999-04-13 | 公開日 | 1999-10-08 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Pig heart short chain L-3-hydroxyacyl-CoA dehydrogenase revisited: sequence analysis and crystal structure determination. Protein Sci., 8, 1999
|
|
8EZG
| Monobody 12D1 bound to KRAS(G12D) | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Hattori, T, Glasser, E, Akkapeddi, P, Ketavarapu, G, Teng, K.W, Koide, A, Koide, S. | 登録日 | 2022-10-31 | 公開日 | 2023-07-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
5AD3
| Bivalent binding to BET bromodomains | 分子名称: | 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D. | 登録日 | 2015-08-19 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Potent and Selective Bivalent Inhibitors of Bet Bromodomains Nat.Chem.Biol., 12, 2016
|
|
1E71
| MYROSINASE FROM SINAPIS ALBA with bound ascorbate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASCORBIC ACID, ... | 著者 | Burmeister, W.P. | 登録日 | 2000-08-23 | 公開日 | 2001-01-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | High Resolution X-Ray Crystallography Shows that Ascorbate is a Cofactor for Myrosinase and Substitutes for the Function of the Catalytic Base J.Biol.Chem., 275, 2000
|
|
5ABD
| CRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF CU | 分子名称: | COPPER (II) ION, SODIUM ION, SULFATE ION, ... | 著者 | Gaucher, J.-F, Lascombe, M.-B, Reille-Seroussi, M, Gagey-Eilstein, N, Broussy, S, Coric, P, Seijo, B, Gautier, B, Liu, W.-Q, Huguenot, F, Inguimbert, N, Bouaziz, S, Vidal, M, Broutin, I. | 登録日 | 2015-08-05 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Biophysical Studies of the Induced Dimerization of Human Vegf R Receptor 1 Binding Domain by Divalent Metals Competing with Vegf-A Plos One, 11, 2016
|
|
7Q18
| Beta-lactoglobulin mutant FAF (I56F/L39A/M107F), unliganded form | 分子名称: | Beta-lactoglobulin, SULFATE ION | 著者 | Loch, J.I, Cymborowski, M.T, Minor, W, Lewinski, K. | 登録日 | 2021-10-18 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | New ligand-binding sites identified in the crystal structures of [beta]-lactoglobulin complexes with desipramine Iucrj, 9, 2022
|
|
1EN4
| CRYSTAL STRUCTURE ANALYSIS OF THE E. COLI MANGANESE SUPEROXIDE DISMUTASE Q146H MUTANT | 分子名称: | MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE | 著者 | Edwards, R.A, Whittaker, M.M, Baker, E.N, Whittaker, J.W, Jameson, G.B. | 登録日 | 2000-03-20 | 公開日 | 2001-06-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Outer sphere mutations perturb metal reactivity in manganese superoxide dismutase. Biochemistry, 40, 2001
|
|
3E50
| Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | 分子名称: | Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION | 著者 | Guo, Q, Manolopoulou, M, Tang, W.-J. | 登録日 | 2008-08-12 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
|
|
2ZBJ
| Crystal structure of Dioclea rostrata lectin | 分子名称: | CALCIUM ION, Lectin alpha chain, MANGANESE (II) ION, ... | 著者 | de Oliveira, T.M, Delatorre, P, da Rocha, B.A.M, de Sousa, E.P, Nascimento, K.S, Bezerra, G.A, Moura, T.R, Benevides, R.G, Bezerra, E.H.S, Moreno, F.B.M.B, Freire, V.N, de Azevedo Jr, W.F, Cavada, B.S. | 登録日 | 2007-10-22 | 公開日 | 2008-08-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of Dioclea rostrata lectin: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins J.Struct.Biol., 164, 2008
|
|
8F5C
| Mirror-image DNA containing 2'-OMe-L-dC modification | 分子名称: | DNA (5'-D(*(0DG))-R(P*(XE6))-D(P*(0DG)P*(0DT)P*(0DA)P*(0DC)P*(0DG)P*(0DC))-3'), MAGNESIUM ION | 著者 | Zhang, W, Dantsu, Y. | 登録日 | 2022-11-13 | 公開日 | 2023-09-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Synthesis and Structural Characterization of 2'-Deoxy-2'-Methoxy-L-Cytidine Nucleic Acids Chemistryselect, 2023
|
|
6UBL
| Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina | 分子名称: | DynF, PALMITIC ACID | 著者 | Kosgei, A.J, Miller, M.D, Xu, W, Bhardwaj, M, Van Lanen, S.G, Thorson, J.S, Phillips Jr, G.N. | 登録日 | 2019-09-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina. Acta Crystallogr.,Sect.F, 78, 2022
|
|
8ELZ
| HRAS R97M Crystal Form 1 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.961 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
|
|
8ELS
| HRAS R97A Crystal Form 1 R-state | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Davis, D, Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
|
|
7VIJ
| Crystal structure of USP7-HUBL domain | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Feng, N, Zeng, K.W. | 登録日 | 2021-09-27 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv, 8, 2022
|
|
7K1D
| Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_77291 | 分子名称: | (3R)-3-{4-[(3R)-4-(3,4-difluorobenzene-1-carbonyl)morpholin-3-yl]-1H-1,2,3-triazol-1-yl}-N-hydroxy-4-(naphthalen-2-yl)butanamide, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 2 To Be Published
|
|
7K1F
| Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88558 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 4 To Be Published
|
|
5A4A
| Crystal structure of the OSK domain of Drosophila Oskar | 分子名称: | MATERNAL EFFECT PROTEIN OSKAR, SULFATE ION | 著者 | Jeske, M, Glatt, S, Ephrussi, A, Mueller, C.W. | 登録日 | 2015-06-05 | 公開日 | 2015-07-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase-and RNA-Binding Activities. Cell Rep., 12, 2015
|
|
7K1E
| Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646 | 分子名称: | 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Liang, W.G, Deprez, R, Bosc, D, Tang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3 To Be Published
|
|
8SVC
| Crystal Structure of SBP from Klebsiella pneumoniae | 分子名称: | Metal ABC transporter substrate-binding protein, SULFATE ION, ZINC ION | 著者 | Giles, M.W, Cole, G.B, Ng, D, McDevitt, C.A, Moraes, T.F. | 登録日 | 2023-05-16 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Zinc acquisition and its contribution to Klebsiella pneumoniae virulence. Front Cell Infect Microbiol, 13, 2023
|
|
5AIM
| |
1EL0
| SOLUTION STRUCTURE OF THE HUMAN CC CHEMOKINE, I-309 | 分子名称: | I-309 | 著者 | Keizer, D.W, Crump, M.P, Lee, T.W, Slupsky, C.M, Clark-Lewis, I, Sykes, B.D. | 登録日 | 2000-03-11 | 公開日 | 2000-09-01 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Human CC chemokine I-309, structural consequences of the additional disulfide bond. Biochemistry, 39, 2000
|
|
3ETW
| Crystal Structure of bacterial adhesin FadA | 分子名称: | Adhesin A, THIOCYANATE ION | 著者 | Nithianantham, S, Xu, M, Wu, N, Shoham, M, Han, Y.W. | 登録日 | 2008-10-08 | 公開日 | 2008-12-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of FadA Adhesin from Fusobacterium nucleatum Reveals a Novel Oligomerization Motif, the Leucine Chain. J.Biol.Chem., 284, 2009
|
|
1IGZ
| Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1. | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | 著者 | Malkowski, M.G, Thuresson, E.D, Smith, W.L, Garavito, R.M. | 登録日 | 2001-04-18 | 公開日 | 2001-12-12 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. J.Biol.Chem., 276, 2001
|
|
3EU5
| Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BiotinGPP | 分子名称: | (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... | 著者 | Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. | 登録日 | 2008-10-09 | 公開日 | 2009-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Analysis of the eukaryotic prenylome by isoprenoid affinity tagging Nat.Chem.Biol., 5, 2009
|
|
3HT5
| |