8EZG
Monobody 12D1 bound to KRAS(G12D)
Summary for 8EZG
Entry DOI | 10.2210/pdb8ezg/pdb |
Related | 8F0M |
Descriptor | GTPase KRas, Monobody 12D1, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | signaling protein-de novo protein complex, signaling protein/de novo protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 29379.77 |
Authors | Hattori, T.,Glasser, E.,Akkapeddi, P.,Ketavarapu, G.,Teng, K.W.,Koide, A.,Koide, S. (deposition date: 2022-10-31, release date: 2023-07-19, Last modification date: 2023-10-25) |
Primary citation | Akkapeddi, P.,Hattori, T.,Khan, I.,Glasser, E.,Koide, A.,Ketavarapu, G.,Whaby, M.,Zuberi, M.,Teng, K.W.,Lefler, J.,Maso, L.,Bang, I.,Ostrowski, M.C.,O'Bryan, J.P.,Koide, S. Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors. Proc.Natl.Acad.Sci.USA, 120:e2302485120-e2302485120, 2023 Cited by PubMed: 37399416DOI: 10.1073/pnas.2302485120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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