8EZG
Monobody 12D1 bound to KRAS(G12D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 168 | 19178.5 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (B) | Monobody 12D1 | polymer | 91 | 9710.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 1 - 168 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Gly 12 | variant |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28889.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 490.5 | |
| All* | Total formula weight | 29379.8 |
