5J0N
 
 | | Lambda excision HJ intermediate | | 分子名称: | Excisionase, Integrase, Integration host factor subunit alpha, ... | | 著者 | Van Duyne, G, Grigorieff, N, Landy, A. | | 登録日 | 2016-03-28 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (11 Å) | | 主引用文献 | Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction.
Elife, 5, 2016
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1XXA
 | | C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX; PB DERIVATIVE | | 分子名称: | ARGININE, ARGININE REPRESSOR, LEAD (II) ION | | 著者 | Van Duyne, G.D, Ghosh, G, Maas, W.K, Sigler, P.B. | | 登録日 | 1995-11-03 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.
J.Mol.Biol., 256, 1996
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1XXB
 | | C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX | | 分子名称: | ARGININE, ARGININE REPRESSOR | | 著者 | Van Duyne, G.D, Ghosh, G, Maas, W.K, Sigler, P.B. | | 登録日 | 1995-11-03 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.
J.Mol.Biol., 256, 1996
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1XXC
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1FKB
 | | ATOMIC STRUCTURE OF THE RAPAMYCIN HUMAN IMMUNOPHILIN FKBP-12 COMPLEX | | 分子名称: | FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | 著者 | Van Duyne, G.D, Standaert, R.F, Schreiber, S.L, Clardy, J.C. | | 登録日 | 1992-07-02 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex
J.Am.Chem.Soc., 113, 1991
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3MGV
 | | Cre recombinase-DNA transition state | | 分子名称: | DNA (5'-D(*CP*AP*TP*AP*TP*GP*CP*TP*AP*TP*AP*CP*GP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*CP*TP*TP*CP*GP*TP*AP*TP*AP*G)-3'), Recombinase cre, ... | | 著者 | Gibb, B.P, Gupta, K, Ghosh, K, Sharp, R, Chen, J, Van Duyne, G.D. | | 登録日 | 2010-04-07 | | 公開日 | 2010-05-26 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Requirements for catalysis in the Cre recombinase active site.
Nucleic Acids Res., 38, 2010
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2HOF
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2HOI
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6VRG
 | | Structure of HIV-1 integrase with native amino-terminal sequence | | 分子名称: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | Eilers, G, Gupta, K, Allen, A, Zhou, J, Hwang, Y, Cory, M, Bushman, F.D, Van Duyne, G.D. | | 登録日 | 2020-02-07 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Influence of the amino-terminal sequence on the structure and function of HIV integrase.
Retrovirology, 17, 2020
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5CRX
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4RG5
 | | Crystal Structure of S. Pombe SMN YG-Dimer | | 分子名称: | MALONATE ION, Maltose-binding periplasmic protein, Survival Motor Neuron protein chimera, ... | | 著者 | Gupta, K, Martin, R.S, Sarachan, K.L, Sharp, B, Van Duyne, G.D. | | 登録日 | 2014-09-29 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Oligomeric Properties of Survival Motor NeuronGemin2 Complexes.
J.Biol.Chem., 290, 2015
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4CRX
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5HOT
 | | Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | | 分子名称: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | | 著者 | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | | 登録日 | 2016-01-19 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
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5U96
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5UDO
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5E6F
 | | Canarypox virus resolvase | | 分子名称: | CNPV261 Holliday junction resolvase protein, D(-)-TARTARIC ACID, MAGNESIUM ION | | 著者 | Li, H, Hwang, Y, Perry, K, Bushman, F.D, Van Duyne, G.D. | | 登録日 | 2015-10-09 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure and Metal Binding Properties of a Poxvirus Resolvase.
J.Biol.Chem., 291, 2016
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5UAE
 | | Crystal structure of the coiled-coil domain from Listeria Innocua Phage Integrase (Trigonal Form) | | 分子名称: | CITRATE ANION, Putative integrase | | 著者 | Gupta, K, Sharp, R, Yuan, J.B, Van Duyne, G.D. | | 登録日 | 2016-12-19 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Coiled-coil interactions mediate serine integrase directionality.
Nucleic Acids Res., 45, 2017
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1CRX
 | | CRE RECOMBINASE/DNA COMPLEX REACTION INTERMEDIATE I | | 分子名称: | CRE RECOMBINASE, DNA (5'-D(*AP*TP*AP*TP*GP*CP*TP*AP*TP*AP*CP*GP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*CP*TP*TP*CP*GP*TP*AP*TP*AP*G)-3'), ... | | 著者 | Guo, F, Gopaul, D.N, Van Duyne, G.D. | | 登録日 | 1997-07-02 | | 公開日 | 1998-10-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse.
Nature, 389, 1997
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6DNW
 | | Sequence Requirements of the Listeria innocua prophage attP site | | 分子名称: | DNA (26-MER), Putative integrase [Bacteriophage A118], ZINC ION | | 著者 | Li, H, Sharp, R, Rutherford, K, Gupta, K, Van Duyne, G.D. | | 登録日 | 2018-06-08 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.849 Å) | | 主引用文献 | Serine Integrase attP Binding and Specificity.
J. Mol. Biol., 430, 2018
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1P27
 | | Crystal Structure of the Human Y14/Magoh complex | | 分子名称: | Mago nashi protein homolog, RNA-binding protein 8A | | 著者 | Lau, C.K, Diem, M.D, Dreyfuss, G, Van Duyne, G.D. | | 登録日 | 2003-04-14 | | 公開日 | 2003-08-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the y14-magoh core of the exon junction complex.
Curr.Biol., 13, 2003
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1NFK
 | | STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER | | 分子名称: | DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB)) | | 著者 | Ghosh, G, Van Duyne, G, Ghosh, S, Sigler, P.B. | | 登録日 | 1995-02-28 | | 公開日 | 1996-12-23 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Nature, 373, 1995
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8CTA
 | | Minimal 2:2 Ternary Complex between BI-224436 bound HIV-1 Integrase Catalytic Core Domain Dimer and Carboxy Terminal Domains | | 分子名称: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase | | 著者 | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | | 登録日 | 2022-05-13 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization.
Plos Pathog., 19, 2023
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8CT5
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8CT7
 | | Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436 | | 分子名称: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase, ... | | 著者 | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | | 登録日 | 2022-05-13 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization.
Plos Pathog., 19, 2023
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3C29
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