5SYB
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![BU of 5syb by Molmil](/molmil-images/mine/5syb) | Crystal structure of human PHF5A | Descriptor: | 1,2-ETHANEDIOL, PHD finger-like domain-containing protein 5A, ZINC ION | Authors: | Tsai, J.H.C, Teng, T, Zhu, P, Fekkes, P, Larsen, N.A. | Deposit date: | 2016-08-10 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Nat Commun, 8, 2017
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6NZ6
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![BU of 6nz6 by Molmil](/molmil-images/mine/6nz6) | YcjX-GDP (type II) | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, YcjX Stress Protein | Authors: | Tsai, J, Sung, N, Lee, J, Chang, C, Lee, S, Tsai, F.T. | Deposit date: | 2019-02-12 | Release date: | 2019-09-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein. J.Mol.Biol., 431, 2019
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5VND
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![BU of 5vnd by Molmil](/molmil-images/mine/5vnd) | Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527 | Descriptor: | 1,2-ETHANEDIOL, Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, ... | Authors: | Tsai, J.H.C, Reynolds, D, Fekkes, P, Smith, P, Larsen, N.A. | Deposit date: | 2017-04-30 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma. Cancer Res., 77, 2017
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4BM5
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![BU of 4bm5 by Molmil](/molmil-images/mine/4bm5) | Chloroplast inner membrane protein TIC110 | Descriptor: | SIMILAR TO CHLOROPLAST INNER MEMBRANE PROTEIN TIC110 | Authors: | Tsai, J.-Y, Chu, C.-C, Yeh, Y.-H, Chen, L.-J, Li, H.-m, Hsiao, C.-D. | Deposit date: | 2013-05-06 | Release date: | 2013-06-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structural Characterizations of Chloroplast Translocon Protein Tic110. Plant J., 75, 2013
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6CAJ
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![BU of 6caj by Molmil](/molmil-images/mine/6caj) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Tsai, J.C, Miller-Vedam, L.E, Anand, A.A, Jaishankar, P, Nguyen, H.C, Renslo, A.R, Frost, A, Walter, P. | Deposit date: | 2018-01-31 | Release date: | 2018-04-11 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science, 359, 2018
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6AFZ
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![BU of 6afz by Molmil](/molmil-images/mine/6afz) | Proton pyrophosphatase-E225H mutant | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.483 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFW
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![BU of 6afw by Molmil](/molmil-images/mine/6afw) | Proton pyrophosphatase-T228D mutant | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.185 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFV
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![BU of 6afv by Molmil](/molmil-images/mine/6afv) | Proton pyrophosphatase-L555K mutant | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFT
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![BU of 6aft by Molmil](/molmil-images/mine/6aft) | Proton pyrophosphatase - E301Q | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Tang, K.-Z, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.492 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFU
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![BU of 6afu by Molmil](/molmil-images/mine/6afu) | Proton pyrophosphatase-L555M mutant | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.798 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFY
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![BU of 6afy by Molmil](/molmil-images/mine/6afy) | Proton pyrophosphatase-E225S mutant | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFS
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![BU of 6afs by Molmil](/molmil-images/mine/6afs) | Proton pyrophosphatase - two phosphates-bound | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Li, K.-M, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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6AFX
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![BU of 6afx by Molmil](/molmil-images/mine/6afx) | Proton pyrophosphatase - E225A | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Tang, K.-Z, Sun, Y.-J. | Deposit date: | 2018-08-08 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol., 431, 2019
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2YIK
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![BU of 2yik by Molmil](/molmil-images/mine/2yik) | Catalytic domain of Clostridium thermocellum CelT | Descriptor: | CALCIUM ION, ENDOGLUCANASE, ZINC ION | Authors: | Tsai, J.-Y, Kesavulu, M.M, Hsiao, C.-D. | Deposit date: | 2011-05-16 | Release date: | 2012-02-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the Catalytic Domain of the Clostridium Thermocellum Cellulase Celt Acta Crystallogr.,Sect.D, 68, 2012
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7L7G
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![BU of 7l7g by Molmil](/molmil-images/mine/7l7g) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ) | Descriptor: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P. | Deposit date: | 2020-12-28 | Release date: | 2021-03-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | eIF2B conformation and assembly state regulates the integrated stress response. Elife, 10, 2021
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6JSX
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![BU of 6jsx by Molmil](/molmil-images/mine/6jsx) | |
6L85
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![BU of 6l85 by Molmil](/molmil-images/mine/6l85) | The sodium-dependent phosphate transporter | Descriptor: | DI(HYDROXYETHYL)ETHER, DODECYL-BETA-D-MALTOSIDE, PHOSPHATE ION, ... | Authors: | Tsai, J.-Y, Sun, Y.-J. | Deposit date: | 2019-11-04 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20. Sci Adv, 6, 2020
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6NZ5
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![BU of 6nz5 by Molmil](/molmil-images/mine/6nz5) | YcjX-GDPCP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, YcjX Stress Protein | Authors: | Lee, S, Tsai, J, Tsai, F.T, Sung, N, Lee, J, Chang, C. | Deposit date: | 2019-02-12 | Release date: | 2019-09-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.233 Å) | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein. J.Mol.Biol., 431, 2019
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6NZ4
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![BU of 6nz4 by Molmil](/molmil-images/mine/6nz4) | YcjX-GDP (type I) | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, YcjX Stress Protein | Authors: | Lee, S, Tsai, J, Tsai, F.T. | Deposit date: | 2019-02-12 | Release date: | 2019-09-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein. J.Mol.Biol., 431, 2019
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8DKN
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![BU of 8dkn by Molmil](/molmil-images/mine/8dkn) | PPARg bound to T0070907 and Co-R peptide | Descriptor: | 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Nuclear receptor corepressor 1 peptide, ... | Authors: | Larsen, N.A, Tsai, J. | Deposit date: | 2022-07-05 | Release date: | 2022-09-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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6UQC
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![BU of 6uqc by Molmil](/molmil-images/mine/6uqc) | Mouse IgG2a Bispecific Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, F, Tsai, J.C, Davis, J.H, West, S.M, Strop, P. | Deposit date: | 2019-10-18 | Release date: | 2020-01-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models. Mabs, 12, 2019
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3ZQC
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![BU of 3zqc by Molmil](/molmil-images/mine/3zqc) | Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal beta-hairpin conformation | Descriptor: | MRE-1, MYB3 | Authors: | Wei, S.-Y, Lou, Y.-C, Tsai, J.-Y, Hsu, H.-M, Tai, J.-H, Hsiao, C.-D, Chen, C. | Deposit date: | 2011-06-09 | Release date: | 2012-04-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Trichomonas Vaginalis Myb3 DNA-Binding Domain Bound to a Promoter Sequence Reveals a Unique C-Terminal Beta-Hairpin Conformation. Nucleic Acids Res., 40, 2012
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4A01
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![BU of 4a01 by Molmil](/molmil-images/mine/4a01) | Crystal Structure of the H-Translocating Pyrophosphatase | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, IMIDODIPHOSPHORIC ACID, MAGNESIUM ION, ... | Authors: | Lin, S.-M, Tsai, J.-Y, Hsiao, C.-D, Chiu, C.-L, Pan, R.-L, Sun, Y.-J. | Deposit date: | 2011-09-07 | Release date: | 2012-03-28 | Last modified: | 2012-04-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure of a Membrane Embedded H1-Translocating Pyrophosphatase Nature, 484, 2012
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4AWX
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![BU of 4awx by Molmil](/molmil-images/mine/4awx) | Moonlighting functions of FeoC in the regulation of ferrous iron transport in Feo | Descriptor: | FERROUS IRON TRANSPORT PROTEIN B, FERROUS IRON TRANSPORT PROTEIN C, NICKEL (II) ION, ... | Authors: | Hung, K.-W, Tsai, J.-Y, Juan, T.-H, Hsu, Y.-L, Hsiao, C.D, Huang, T.-H. | Deposit date: | 2012-06-06 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Klebsiella Pneumoniae Nfeob/Feoc Complex and Roles of Feoc in Regulation of Fe2+ Transport by the Bacterial Feo System. J.Bacteriol., 194, 2012
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5GPJ
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![BU of 5gpj by Molmil](/molmil-images/mine/5gpj) | Crystal Structure of Proton-Pumping Pyrophosphatase | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, Pyrophosphate-energized vacuolar membrane proton pump | Authors: | Li, K.M, Tsai, J.Y, Sun, Y.J. | Deposit date: | 2016-08-03 | Release date: | 2016-12-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism Nat Commun, 7, 2016
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