5VND

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527

Summary for 5VND

Entry DOI	10.2210/pdb5vnd/pdb
Descriptor	Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	fgfr4, h3b-56527, covalent compound, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	72729.00
Authors	Tsai, J.H.C.,Reynolds, D.,Fekkes, P.,Smith, P.,Larsen, N.A. (deposition date: 2017-04-30, release date: 2017-05-24, Last modification date: 2023-10-04)
Primary citation	Joshi, J.J.,Coffey, H.,Corcoran, E.,Tsai, J.,Huang, C.L.,Ichikawa, K.,Prajapati, S.,Hao, M.H.,Bailey, S.,Wu, J.,Rimkunas, V.,Karr, C.,Subramanian, V.,Kumar, P.,MacKenzie, C.,Hurley, R.,Satoh, T.,Yu, K.,Park, E.,Rioux, N.,Kim, A.,Lai, W.G.,Yu, L.,Zhu, P.,Buonamici, S.,Larsen, N.,Fekkes, P.,Wang, J.,Warmuth, M.,Reynolds, D.J.,Smith, P.G.,Selvaraj, A. H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma. Cancer Res., 77:6999-7013, 2017 Cited by PubMed: 29247039 DOI: 10.1158/0008-5472.CAN-17-1865 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation