5VND

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 9ES A 801

Chain	Residue
A	VAL492
A	GLY567
A	GLU571
A	ALA640
A	ASP641
A	EDO806
A	LEU494
A	ALA512
A	LYS514
A	GLU531
A	VAL559
A	VAL561
A	GLU562
A	ALA564

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 802

Chain	Residue
A	SER584
A	TYR585
A	HOH944
A	HOH972
B	ARG734

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 803

Chain	Residue
A	ARG570
A	ARG627
A	THR657
A	ASN659
A	ARG661
A	HOH906
A	HOH912

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 804

Chain	Residue
A	TRP684
A	TYR701
A	ARG718
A	MET719
A	TRP737
A	HOH911

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 805

Chain	Residue
A	THR746
A	PHE747
A	LYS748
A	HOH915
A	HOH920

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 806

Chain	Residue
A	ARG627
A	ASN628
A	ASP641
A	9ES801

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 807

Chain	Residue
A	ARG577
A	GLY698
A	SER699
A	HOH948

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 808

Chain	Residue
A	THR726
A	ASN727
A	GLU728

---

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO A 809

Chain	Residue
A	LYS542
A	ARG609

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO A 810

Chain	Residue
A	LYS665
A	SER699
A	GLY703
A	HOH925
A	HOH947
A	HOH952

---

site_id	AD2
Number of Residues	8
Details	binding site for residue EDO A 811

Chain	Residue
A	PRO745
A	THR746
A	GLN749
A	HOH907
A	HOH936
B	ASP554
B	GLY555
B	PRO556

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 812

Chain	Residue
A	GLU708
A	LYS711
A	LEU712
A	GLU715
B	GLY703
B	HOH989

---

site_id	AD4
Number of Residues	14
Details	binding site for residue 9ES B 801

Chain	Residue
B	VAL492
B	LEU494
B	LYS514
B	GLU531
B	VAL559
B	VAL561
B	GLU562
B	ALA564
B	GLU571
B	LEU630
B	ALA640
B	ASP641
B	PHE642
B	HOH936

---

site_id	AD5
Number of Residues	7
Details	binding site for residue SO4 B 802

Chain	Residue
B	ARG570
B	ARG627
B	THR657
B	ASN659
B	ARG661
B	HOH917
B	HOH933

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 B 803

Chain	Residue
B	VAL601
B	PHE694
B	ASN724
B	THR726
B	LEU729

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO B 804

Chain	Residue
B	MET719
B	TRP737
B	HOH922
B	TRP684
B	TYR701
B	ARG718

---

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO B 805

Chain	Residue
B	GLY580

---

site_id	AD9
Number of Residues	9
Details	binding site for residue EDO B 806

Chain	Residue
A	ASP735
A	HIS738
A	HOH942
A	HOH984
B	LEU516
B	LYS517
B	SER518
B	PRO556
B	HOH901

---

site_id	AE1
Number of Residues	3
Details	binding site for residue EDO B 807

Chain	Residue
B	GLU728
B	ASP753
B	ARG756

---

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO B 808

Chain	Residue
B	ASP735
B	GLN743
B	PRO745

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---